Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
PURPOSE OF REVIEW: This network meta-analysis (NMA) compares the efficacy of dietary interventions in improving flow mediated dilation (FMD) as a measure of endothelial function among individuals with...
Variation in the use of electrical cardioversion and catheter ablation for atrial fibrillation/flutter according to sex and ethnicity in Aotearoa New Zealand.
AIM: The aim of this article was to examine clinical and demographic factors associated with receipt of rhythm control procedures (electrical cardioversion [ECV] or ablation) in patients with atrial f...
Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets.
The glymphatic system is a brain-wide metabolic clearance pathway, orchestrating the removal of neurotoxic wastes via glial-dependent perivascular networks. Mediated by polarized aquaporin-4 (AQP4) ch...
From guidelines to practice: general practitioners' consensus on indicators for managing selected multimorbidity in primary care in Western Australia.
BACKGROUND: Multimorbidity is rising in primary care, yet adherence to guidelines is hindered by fragmented, disease-specific recommendations. This study sought to establish consensus among general pr...
Pulmonary congestion assessed by lung ultrasound in stable ambulatory patients with heart failure and preserved ejection fraction in primary care.
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) accounts for a growing proportion of heart failure cases. Pulmonary congestion, particularly subclinical congestion, is often underes...
Assessing the risk of drug-induced corrected QT interval prolongation in primary care.
BACKGROUND: Tisdale risk score has been validated for predicting drug-induced QTc prolongation (QTP) in cardiac care. This study aims to determine whether it can guide prescribing and monitoring of QT...
Superior mesenteric artery Doppler after first feed and its association with feed intolerance and necrotizing enterocolitis in very low birth weight neonates: a prospective cohort study.
To evaluate the association of superior mesenteric artery (SMA) Doppler parameters after the first feed with feed intolerance and necrotizing enterocolitis (NEC) in very low birth weight (VLBW) neonat...
The AGE-RAGE-DIAPH1 Axis in Type 2 Diabetes and Metabolic Dysfunction: From Carbonyl Stress to Diabetic Myocardial and Neuronal Injury.
Carbonyl stress, chronic inflammation, and progressive tissue injury accompany type 2 diabetes mellitus (T2DM) and obesity. Yet, the molecular systems that connect these processes with cardiac, vascul...
Vericiguat in the Post-Stabilization Phase of HFrEF: Targeting Residual Risk Across the Ischemia-Decompensation Continuum.
Vericiguat is currently indicated for patients with heart failure with reduced ejection fraction (HFrEF) following recent clinical worsening, based on evidence demonstrating a reduction in cardiovascu...
The Impact of Risk Factors and Comorbidities on Heart Failure in the Aging Population.
Heart failure (HF) represents a major and escalating public health challenge in the aging population. Older adults with HF frequently present with coexisting conditions such as hypertension, diabetes ...
A Cascaded Quantized Spiking Neural Network for Real-Time ECG Arrhythmia Detection on Edge Hardware.
Wearable ECG monitors enable continuous cardiac surveillance, but most still rely on cloud-based analysis with limited on-device support for multi-class arrhythmia detection. Spiking neural networks (...
Risk of Long-Term Clozapine Medication over Decades for Cardiac Adverse Events Including Heart Failure and Its Pathophysiology: A Japan and China Retrospective Cohort Analysis.
Background/Objectives: Clozapine is the sole antipsychotic approved for treatment-resistant schizophrenia, but it is a double-edged therapeutic option due to various lethal adverse reactions. This stu...
Frequency and Risk Factors for Diuretic Resistance in Patients with Decompensated Heart Failure: A Retrospective Single-Center Study in Western Mexico.
BACKGROUND/OBJECTIVES: Diuretic resistance is a recognized complication in patients with heart failure (HF) and is associated with worse clinical outcomes; however, information regarding its frequency...
Minimally invasive pulmonary valve replacement via left anterior mini-thoracotomy after Tetralogy of Fallot repair: a five-patient case series.
BACKGROUND: Pulmonary regurgitation is a common long-term consequence after Tetralogy of Fallot (TOF) repair and often leads to right ventricular dilatation requiring pulmonary valve replacement (PVR)...
The association of triglyceride-glucose index with acute myocardial infarction and all-cause mortality in patients with coronary artery disease stratified by acute myocardial infarction status: a large-scale retrospective cohort study from South China.
OBJECTIVES: This study aimed to investigate the association of the triglyceride-glucose (TyG) index with the risk of acute myocardial infarction (AMI) and all-cause mortality in patients with coronary...
Experiences of Patients With Atrial Fibrillation Using Technology to Personalize Self-Care Decision-Making: Interpretive Description Study.
BACKGROUND: Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is a challenging chronic disease to manage. Patients' daily self-care decisions are associated with improved...
Histaminylation alters collagen matrix mechanics and attenuates cardiac fibrosis post-myocardial infarction via mechanotransduction signaling axis.
Histaminylation is a newly discovered monoaminylation catalyzed by transglutaminase 2 (TGM2), and its role in myocardial fibrosis has not yet been elucidated. Here, we identified histaminylation in ca...
Recognition, treatment, and control of hypertension in the Danish population-based Lolland-Falster Health Study.
In the Danish population-based Lolland-Falster Health Study (LOFUS), conducted in a socioeconomically disadvantaged area with marked regional health inequalities, we recently identified a hypertension...
Predictors of Heart Failure in Pediatric Patients with End-Stage Kidney Disease Secondary to Nephrotic Syndrome.
Background and Objectives: To investigate prognostic risk factors and determine the incidence, clinical characteristics, and predictors of heart failure (HF) development in pediatric patients with end...
Editorial for the Special Issue "Diabetes, Hypertension, and Cardiovascular Diseases: New Insights, Risk Factors, and Drug Therapies".
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide [...].