[Overall pathophysiological network of sarcopenia secondary to chronic heart failure from perspectives of modern medicine and TCM].

Sarcopenia is a common and serious complication of chronic heart failure(CHF), with the two conditions forming a vicious cycle. However, the systemic pathological network underlying sarcopenia seconda...

Effect of L‑arginine supplementation on homocysteine and asymmetric dimethylarginine in atherosclerotic lower limb ischemia.

Chronic lower limb ischemia is a manifestation of systemic atherosclerosis frequently accompanied by lipid metabolism disorders, endothelial dysfunction, and disturbances in the L-arginine-nitric oxid...

Cardioprotective role of wedelolactone in restraint stress-triggered myocardial damage and cardiac arrhythmias in Wistar rats.

Restraint stress is a well-established model for inducing psychological and physiological stress that triggers oxidative damage, inflammation, and apoptosis in cardiac tissue. Wedelolactone, a bioacti...

Assessment of Coronary Sinus Flow and Dimensions by Transthoracic Echocardiography in Patients with Atrioventricular Nodal Reentrant Tachycardia.

BACKGROUND: The coronary sinus (CS) plays a pivotal role in cardiac venous drainage and is anatomically adjacent to the atrioventricular nodal region. Although structural enlargement of the CS has bee...

Primary prevention of coronary heart disease in women.

Coronary heart disease (CHD) is a leading cause of death in women. Observational studies have consistently shown estrogen to help prevent CHD in postmenopausal women. The large randomised controlled W...

Alteration of the aortic wall structure and biomechanics in the sealing zone after EVAR: insights from an experimental study.

BACKGROUND: Endovascular repair has become state of the art for treating thoracic and abdominal aortic aneurysms. However, complications such as endoleaks or the development of aortic neck dilatation,...

[Development, morphogenesis, and regeneration of cardiac Purkinje fibers].

Ventricular arrhythmias often originate in the Purkinje system, a network of specialized cardiomyocytes located on the luminal surface of the ventricles. The Purkinje system is part of the ventricular...

Perioperative safety and short-term survival outcomes of radical nephrectomy with thrombectomy in geriatric renal cell carcinoma patients with venous tumor thrombus.

BACKGROUND: The aim of this study was to evaluate the feasibility and safety of radical nephrectomy with thrombectomy for geriatric renal cell carcinoma (RCC) patients with venous tumor thrombus (VTT)...

[Reflections on the management of a case of neurogenic stress cardiomyopathy complicated by acute submassive pulmonary embolism].

Due to their unique pathophysiological states, neurocritical care patients are at a significantly increased risk of acute pulmonary embolism. Typical symptoms are frequently masked by neurological def...

[Predictive value of the Vasoactive Inotropic Score for 28-day mortality in patients with atrial fibrillation-related hemodynamic deterioration in the intensive care unit].

OBJECTIVE: To evaluate the predictive value of the Vasoactive Inotropic Score (VIS) for 28-day mortality in intensive care unit (ICU) patients with atrial fibrillation (AF)-related hemodynamic deterio...

[Research advances in mechanisms and detection methods of vascular endothelial barrier dysfunction in sepsis-induced organ injury].

Sepsis-induced multiple organ dysfunction syndrome (MODS) is the leading cause of mortality in critically ill patients, and widespread disruption of the vascular endothelial barrier represents the cen...

Aberrant TMPRSS6-Protease Regulation of Disease Mutant HCN4-KCNE1 Channel Complex Depends on the KCNE1-G38S Polymorphism.

The sinoatrial node pacemaker channel HCN4 plays a central role in cardiac automaticity, and disease-associated variants can predispose to atrial arrhythmias. Here, we investigated the functional inte...

Structural model of health-promoting behavior in middle-aged Korean women with hypertension based on the Information-Motivation-Behavioral Skills model: a cross sectional study.

PURPOSE: This study aimed to develop and evaluate a hypothetical model of health-promoting behaviors among middle-aged women with hypertension, guided by the Information-Motivation-Behavioral Skills (...

Delivering Lifestyle Interventions for Chronic Disease Care Sustainably and at Scale through Virtual Shared Medical Appointments in Primary Care.

Behavior changes related to nutrition, physical activity, sleep, alcohol, and smoking are critical for the prevention and management of many chronic diseases, but interventions to implement these beha...

Targeting atherosclerotic inflammation: Advances in NLRP3 inflammasome inhibitors beyond LDL-C.

Atherosclerosis, the main pathological background of cardiovascular diseases, is not only characterized by lipid metabolism disorders but also chronic inflammation as a major driver of disease progres...

Breaking The Stone: Stentless Coronary Revascularization with Intravascular Lithotripsy and Drug-Coated Balloon Technology Guided by IVI.

Background: Severe coronary calcification remains a major challenge in percutaneous coronary intervention (PCI), often complicating lesion preparation and stent expansion. Intravascular lithotripsy (I...

Intracoronary stem cell transplant in ischemic heart disease: a meta-analysis of randomized trials.

OBJECTIVE: Ischemic heart disease is a leading cause of morbidity and mortality. In this study, we assessed the efficacy of intracoronary stem cell transplantation on left ventricular function (LVEF) ...

Electrical coupling between transplanted cardiomyocytes and host myocardium to prevent arrhythmia.

Transplantation of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes offers new opportunities for myocardial repair after infarction. However, as demonstrated in large-animal model st...

Socioeconomic and lifestyle factors influencing non-communicable disease prevalence among rural Jamaican adults: a population-based study.

INTRODUCTION: Non-communicable diseases (NCDs) represent a major public health challenge in Jamaica, particularly within rural communities where socioeconomic and infrastructural barriers may heighten...

The determination of the heart size in 100 clinically thorax-disease-free pet rabbits (Oryctolagus cuniculus forma domestica) using the Vertebral Heart Score (VHS).

OBJECTIVE: To establish reference values for the Vertebral Heart Score (VHS) in pet rabbits that are clinically free of thorax disease. MATERIALS AND METHODS: Radiographs of 100 pet rabbits without cl...