[Non-portal hypertension-related upper gastrointestinal bleeding].
Non-portal hypertension-related upper gastrointestinal bleeding (UGIB) remains one of the most common emergencies in gastroenterology, accounting for the majority of UGIB cases in Western countries.It...
Association Between PCSK9 Inhibitor Use and Risk of Age-Related Macular Degeneration.
PURPOSE: Age-related macular degeneration (AMD) has been linked to systemic lipid imbalance, vascular dysfunction, and inflammation. The ocular effects of proprotein convertase subtilisin/kexin type 9...
Functional Rice Enriched With Resistant Starch Ameliorates Metabolic Dysregulation in High-Fat Diet-Induced Obese Mice.
Resistant starch (RS) is a non-digestible fraction of dietary starch that modulates glucose and lipid metabolism. In this study, a RS-enriched high-amylose rice (R-HAR) was developed using a mild citr...
Direct Oral Anticoagulants, COX-2-Selective NSAIDs, and Gastrointestinal Bleeding in Atrial Fibrillation.
IMPORTANCE: It is unclear whether the beneficial effects of nonsteroidal anti-inflammatory drugs (NSAIDs) that selectively inhibit cyclooxygenase 2 (COX-2) in decreasing the risk of gastrointestinal (...
Discordant ANCA Positivity in Immune Complex Glomerulonephritis Secondary to Bartonella henselae Prosthetic Valve Endocarditis.
Bartonella henselae is an intracellular bacterium which classically causes cat scratch disease as well as culture-negative endocarditis. We report a man in his 60s, with a mechanical aortic valve repl...
Predictors of Left Ventricular Fibrosis in Mitral Annular Disjunction: Cardiac Magnetic Resonance Imaging Study.
BACKGROUND: Mitral annular disjunction (MAD) is an anatomical anomaly increasingly recognized for its association with myocardial fibrosis and malignant arrhythmias. Identifying predictors of this fib...
Effects of sodium-glucose cotransporter 2 inhibitors on cardiovascular outcomes in chronic obstructive pulmonary disease: A systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials.
ObjectiveSodium-glucose cotransporter 2 inhibitors are widely used in the management of diabetes mellitus and have demonstrated substantial cardiovascular and renal protective effects, particularly in...
[Concepts of Cerebrospinal Fluid Management Based on a Paradigm Shift in CSF Dynamics:From the Third Circulation to the Glymphatic System and Meningeal Lymphatic Drainage].
Over the past century, cerebrospinal fluid (CSF) dynamics have largely been interpreted through the "third circulation theory," which posits that CSF is produced by the choroid plexus that flows from ...
Understanding the severity and anatomical pattern of coronary artery disease (CAD), particularly whether lesions are focal or diffuse, is critical in determining the most effective treatment strategy ...
This study aimed to evaluate the efficacy of angiotensin-converting enzyme inhibitors (ACEi) in preventing anthracycline-induced cardiotoxicity in patients undergoing anthracycline-based chemotherapy....
Protein kinase C isoforms are crucial in hypertension-associated vascular dysfunction. Our previous study suggested that upregulated PKCβ2 contributed to aorta hypercontraction in spontaneously hypert...
Coronary heart disease (CHD) remains a leading cause of cardiovascular morbidity and mortality worldwide, posing a global health threat. In recent years, angiotensin-like proteins (ANGPTLs) have emerg...
Human arterial blood pressure follows a circadian rhythm, where pressure is highest during the day and lowest during the night. Patients with hypertension can have either a preserved rhythm or a dampe...
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Incidence, Predictors, Management, and Clinical Impact of Major Bleeding Following Left Atrial Appendage Occlusion: The Amulet IDE Randomized Clinical Trial.
Left atrial appendage occlusion (LAAO) is used in patients with contraindications to oral anticoagulation, who are at increased risk for major bleeding (MB). To evaluate the incidence, predictors, man...
Oral Semaglutide and Change in Cardiovascular Risk Factors in High-Risk Type 2 Diabetes: A Post Hoc Secondary Analysis of the SOUL Randomized Clinical Trial.
Individuals with type 2 diabetes (T2D) are at high risk of atherosclerotic cardiovascular disease (ASCVD). In the SOUL randomized clinical trial, once-daily oral semaglutide reduced risk of major adve...