Mechanisms of GLP-1 Receptor Agonists in HFpEF: Exploring Weight-Dependent and Independent Drivers of Therapeutic Benefit.
Heart failure with preserved ejection fraction is a complex and increasingly prevalent condition often associated with metabolic comorbidities such as obesity, diabetes, and hypertension. Although its...
Transthyretin amyloid cardiomyopathy (ATTR-CM) remains underdiagnosed relative to population estimates in at-risk populations. Efforts have identified clinical features that identify risk for the diag...
[Influenza virus infection affects the efficacy of the treatment of dyslipidemia in mice with a polyisoprenoid-based drug].
OBJECTIVE: To evaluate how influenza infection affects the hypolipidemic effect of a novel combined drug - Prenophytol based on polyisoprenoids (sodium polyprenyl phosphate and beta-sitosterol) in mic...
Effects of Diazepam Addition to Standard Treatment of Atrial Fibrillation in Emergency Department Settings: A Unicentric Retrospective Study.
Background and Objectives: Diazepam, a GABAA receptor agonist with sympatholytic properties, is sometimes co-administered with antiarrhythmic agents in the emergency management of atrial fibrillation ...
Right Anterior Thoracotomy Versus Partial Sternotomy for Isolated Aortic Valve Replacement: A Propensity Analysis of Clinical Outcomes and Hospital Costs.
Background and Objectives: Previous comparisons between right anterior mini-thoracotomy (RAT) and partial upper sternotomy (PS) for aortic valve replacement (AVR) have shown similar clinical outcomes....
Association of Elevated Lipoprotein(a) Levels with Major Adverse Cardiovascular Events in Non-Diabetic Patients with Acute Myocardial Infarction: A Cohort Study from Bosnia and Herzegovina.
BACKGROUND/OBJECTIVES: Elevated lipoprotein(a) [Lp(a)] is an independent causal risk factor for atherosclerotic cardiovascular disease and may contribute to increased coronary complexity and adverse o...
Distinct Echocardiographic Phenotypes in Primary vs. Secondary Iron Overload Cardiomyopathy: A Pilot Study on Myocardial Work Indices.
Background: Iron overload cardiomyopathy (IOC) is a major determinant of outcomes in hemochromatosis, and conventional echocardiography may miss early myocardial toxicity. Comparative data on primary ...
Clinical Presentation, Etiology, and Outcomes of HIV-Associated Cardiomyopathy: A Systematic Review of Published Case Reports.
HIV-associated cardiomyopathy is a significant cause of morbidity and mortality among people living with HIV, contributing to heart failure, arrhythmia, and sudden cardiac death. Despite its clinical ...
[Untargeted metabolomics-based exploration of potential metabolic biomarkers for subclinical atherosclerosis in metabolic-associated fatty liver disease].
OBJECTIVES: Cardiovascular disease is the most common extrahepatic complication and leading cause of death in metabolic dysfunction‑associated fatty liver disease (MAFLD). However, early metabolic bio...
[Clinical application value of sST2 in patients with heart failure].
OBJECTIVES: Accurate diagnosis and prognostic assessment of heart failure are crucial for improving patients' quality of life. This study aims to investigate the clinical value of serum soluble growth...
Barriers and Facilitators to the Use of Novel Injectable Lipid-Lowering Therapies in Patients with Dyslipidemia or Cardiovascular Disease: A Scoping Review.
Background/Aim: Cardiovascular disease (CVD) represents a relevant global public health challenge with dyslipidemia as a major modifiable cardiovascular risk factor (CVRF). Recent advances have introd...
Valve-in-Valve TAVR in Surgical Stentless Aortic Bioprostheses, a Challenging Scenario.
Background and objectives: Valve-in-valve transcatheter aortic valve replacement (ViV TAVR) has become an established treatment for failed surgical bioprostheses in patients at high surgical risk. How...
Vascular smooth muscle cell (VSMC) phenotypic remodelling is pivotal to neointimal hyperplasia (NH), a common pathological response to vascular injury. COPS5/CSN5/JAB1 harbours the deneddylase of the ...
Outcomes and Predictors of In-Hospital Mortality After Isolated Coronary Artery Bypass Grafting in Patients with Severe Ischemic Cardiomyopathy: A Single-Centre Retrospective Analysis.
BACKGROUND: Patients with coronary artery disease (CAD) and severely reduced left ventricular ejection fraction (LVEF) ≤ 30% represent a high-risk group for coronary artery bypass grafting (CABG). Out...
[Cardiac Tamponade Death Due to Rupture of Coronary Artery Aneurysm Caused by Incomplete Kawasaki Disease： A Case Report].
某男婴，4月龄，因“腹泻半个月，发热4 d”入院。入院时查体:体温38.0 ℃，双眼球结膜未见充血，口唇略干燥，咽部充血，颈软，无皮疹改变。入院当日查血常规示:白细胞26.1×109/L↑（参考值4.3×109~14.2×109/L），红细胞4.0×1012/L（参考值3.3×1012~5.2×1012/L），血小板774×109/L↑（参考值183×109~614×109/L）。给予头孢噻肟、万...
Calcium Channel Blockers in Critical Care Medicine: Current Clinical Applications and Future Investigational Perspectives.
Calcium channel blockers (CCBs) are frequently used in the emergency department and intensive care unit for a wide range of critical conditions, including atrial fibrillation, hypertensive emergencies...
Hypertension-Associated Acetate Deficiency Enhances Platelet Activation and Thrombosis Via Olfr78.
Arterial thrombotic events constitute the leading cause of mortality in hypertension. Gut dysbiosis induces endothelial dysfunction and systemic inflammation, contributing to hypertension and its asso...
Association of ACE I/D and ACE (rs4343) polymorphism with MACE development in hypertensive patients.
OBJECTIVE: Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide. The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and ACE rs4343 polymorphism have been c...
Steroid use and lipid abnormalities in children: assessing the risk in chronic disease management.
Although steroid-induced dyslipidemia is well-documented in adults, its impact on children remains underexplored. Given the long-term cardiovascular risks associated with dyslipidemia, understanding i...