Shared neuropathological features of mild traumatic brain injury and anesthesia.

Mild traumatic brain injuries are highly prevalent and can produce persistent sequelae, creating substantial personal and societal burdens. Recent evidence suggests that anesthesia administration for ...

The potential connection between inflammatory bowel disease and Alzheimer's disease: mechanistic insights and therapeutic implications.

Inflammatory bowel disease (IBD) and Alzheimer's disease (AD) are two chronic conditions previously considered pathologically unrelated. However, accumulating epidemiological evidence suggests that pa...

Association of the TyG index and inflammatory burden index with AMR-defined coronary microvascular dysfunction and 12-month MACE after STEMI.

BACKGROUND: Metabolic dysfunction and inflammation may jointly contribute to coronary microvascular injury and adverse outcomes after primary percutaneous coronary intervention (PPCI) for ST-segment e...

Simulation Study on Preanalytical Variables in Coagulation Testing: Interference Effects and Threshold Determination of Hemolysis, Lipemia, Icterus and Insufficient Sample Volume.

ObjectiveTo systematically evaluate the interference degree of hemolysis, lipemia, icterus, and sample collection volume on routine test items of the ACL TOP750 automatic coagulation analyzer, assess ...

Single vs. dual antiplatelet therapy before DOAC initiation in acute ischemic stroke with atrial fibrillation: a retrospective cohort study.

BACKGROUND: The optimal antiplatelet bridging strategy before initiating direct oral anticoagulants (DOACs) in patients with acute ischemic stroke (AIS) and non-valvular atrial fibrillation (NVAF) rem...

Aortic dissection as a disease of vascular wall homeostasis: integrating vasa vasorum-inflammation-metabolism axis for mechanistic insight and clinical translation.

Aortic dissection (AD) has traditionally been viewed as an acute structural failure initiated by an intimal tear. However, accumulating evidence suggests that this catastrophic event represents the en...

Barrier-Immune Gating Failure in Gut-Brain Neuroinflammation: A Working Hypothesis and Conceptual Framework.

In the past two decades, advances in microbiomics and neuroimmunology have reframed the concept of "central immune privilege." Rather than simply proving a gut-brain connection, the translational chal...

Experimental techniques to evaluate IA-MSCs-mediated alleviation of vasogenic edema following ischemic stroke.

Ischemic stroke induced cerebral edema is a devastating complication which leads to excessive swelling, increased intracranial pressure (ICP) and rapid neurological deterioration. The mortality rate o...

Sitosterolemia: A Rare Cause of Severe Hypercholesterolemia in Children.

INTRODUCTION: Severe hypercholesterolemia in children is commonly caused by familial hypercholesterolemia (FH); however, sitosterolemia, a rare autosomal recessive disorder, should be considered when ...

The Congenital Heart Disease in Children: Kidney-Associated Conditions with Epidemiologic Endpoints (CHICKADEE) study: Study design and protocol.

BACKGROUND: Congenital heart disease (CHD) is the most common structural birth defect affecting 1% of live births. With improvements in medical and surgical management, there are now more than 2 milli...

Intraventricular Left Anterior Descending Artery in a Patient with Ventricular Tachycardia - Innocent Bystander with Significant Procedural Implications.

INTRODUCTION: An intra-right ventricular course of the left anterior descending (LAD) artery is a rare coronary anomaly with uncertain clinical and procedural significance. We describe the use of mult...

The CD47 signaling axis regulates the formation and vulnerability of atherosclerotic plaques: mechanism analysis and targeting strategies.

CD47-centered signaling, involving the functionally distinct CD47-SIRPα and TSP-1-CD47 axes, has been increasingly implicated in the regulation of vascular inflammation, cellular clearance, and athero...

The potential role of trained immunity in HIV-associated atherosclerotic cardiovascular disease: mechanisms and therapeutic implications.

BACKGROUND: People living with HIV (PLWH) exhibit a markedly elevated risk of developing atherosclerotic cardiovascular disease (ASCVD), a phenomenon not entirely attributable to conventional risk fac...

Lacunar stroke with and without chronic imaging biomarkers of small vessel disease: clinical profiles and stroke etiology.

INTRODUCTION: Chronic cerebral small vessel disease (CSVD) may help distinguish different etiological mechanisms in acute lacunar stroke; this study aimed to compare vascular risk factors and stroke e...

The association between body mass index and lower extremity deep venous abnormalities identified by computed tomography venography.

OBJECTIVE: To investigate the association between body mass index (BMI) and lower-extremity deep venous (LEDV) abnormalities, including thrombosis and stenosis, identified by computed tomography venog...

Adverse cardio-metabolic risk profile and epicardial adiposity in patients with adrenal adenoma: a cross-sectional study.

BACKGROUND: Mild autonomous cortisol secretion (MACS) is associated with an increased cardiovascular mortality, but even patients with non-functioning adrenal adenoma (NFA) might be at risk for cardio...

Regulatory T cells in cardiac allograft vasculopathy: from mechanistic insights to clinical tolerance.

Cardiac allograft vasculopathy (CAV) is the primary impairment that influences the long-term prognosis of transplanted hearts. CAV is characterized by diffuse intimal hyperplasia of the coronary arter...

Behavioral and health-factor domains of Life's Essential 8 in advanced cardiovascular-kidney-metabolic syndrome among Korean adults: a nationally representative cross-sectional analysis.

INTRODUCTION: Life's Essential 8 (LE8) summarizes cardiovascular health through four behavioral and four health-factor metrics, whereas cardiovascular-kidney-metabolic (CKM) syndrome staging character...

Impact of cavernous internal carotid artery tortuosity on technical and clinical outcomes in mechanical thrombectomy for acute ischemic stroke: a single-center retrospective study.

BACKGROUND AND PURPOSE: Cavernous internal carotid artery (ICA) tortuosity may hinder catheter navigation during mechanical thrombectomy (MT) for acute ischemic stroke (AIS). However, its impact on pr...

Astrocyte-blood-brain barrier crosstalk in cerebral small vessel disease: linking barrier dysfunction to neurovascular failure.

Cerebral small vessel disease (CSVD) is a heterogeneous group of disorders involving the cerebral microvasculature and is a major cause of stroke and vascular cognitive impairment. The role of blood-b...