Bovine serum albumin sensitizes the mouse brain to lipopolysaccharides.

This study examined the role of bovine serum albumin (BSA) in lipopolysaccharide (LPS)-induced brain injury. Mice were intraperitoneally injected with either LPS or LPS coupled with BSA. Brain tissues...

The impact of endurance training on reducing inflammatory markers in the cardiac tissue of methamphetamine-exposed rats.

BACKGROUND: Methamphetamine (METH) consumption has significant harmful effects on the cardiovascular system, which can be mitigated by endurance training (ET). This study aimed to investigate the effe...

Assessment of the quality and reliability of public health communication about hypertension on short video platforms in China.

BACKGROUND: Hypertension is one of the major modifiable cardiovascular risk factors in China. Persistent and poorly controlled hypertension contributes to a wide spectrum of adverse cardiovascular out...

Metabolic score for insulin resistance is associated with metabolic dysfunction-associated steatotic liver disease among adults with hypertension: a cross-sectional secondary analysis of a Chinese single-center health check-up population.

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD; formerly termed non-alcoholic fatty liver disease) and hypertension frequently coexist within the same cardiometabolic cont...

AI-assisted segmentation-based fusion model integrating deep learning, radiomics, and clinical parameters for identifying coronary heart disease risk in patients with MAFLD.

BACKGROUND/OBJECTIVES: Metabolic dysfunction-associated fatty liver disease (MAFLD) is associated with an increased risk of coronary heart disease (CHD), which is one of the leading causes of chronic ...

Prevalence and associated factors of cognitive frailty in older adults with heart failure: a systematic review and meta-analysis.

OBJECTIVES: To explore the prevalence and associated factors of cognitive frailty in older adults with heart failure. DESIGN: A systematic review and meta-analysis. METHODS: We systematically searched...

Stent Retriever-Assisted Embolic Protection During Recanalization of Chronic Internal Carotid Artery Occlusion with Contralateral Carotid Stenosis: A Case Report.

BACKGROUND: Chronic internal carotid artery occlusion (CICAO) with contralateral stenosis confers high stroke risk, particularly when thrombocytopenia complicates dual antiplatelet therapy (DAPT). We ...

Systemic inflammatory and metabolic disease progression persists despite prevention of myocarditis in Isg15-deficient Coxsackievirus B3 infection.

INTRODUCTION: Type I interferon responses are critical determinants of organ-specific antiviral control and metabolic adaptation during Coxsackievirus B3 (CVB3) infection. The interferon-stimulated ge...

Changes in vascular structure and function in primary hyperparathyroidism: a systematic review and meta-analysis.

INTRODUCTION: Cardiovascular (CV) diseases, particularly ischemic heart disease and stroke, remain the leading cause of mortality worldwide and constitute a major global health challenge. Primary hype...

Findings from the RAW Study: a narrative review of postoperative complications, patient factors, venous resection, and adjuvant treatment.

This review synthesizes the findings of the four studies derived from the Recurrence After Whipple's (RAW) project, which examine postoperative complications, patient-related factors, surgical techniq...

The relation between physical activity and cardiac autonomic dysfunction in patients with chronic obstructive pulmonary disease.

BACKGROUND: Cardiac autonomic dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). Although exercise training improves cardiac autonomic function, the effects of changi...

Impact of prehospital triggers, time of onset, and symptom-to-door time on the prognosis of patients with coronary heart disease.

OBJECTIVE: This study aims to conduct a prehospital registry study on coronary heart disease (CHD) to investigate the effects of prehospital triggers, time of onset, and symptom-to-door time (S2D) on ...

Microglial immunosurveillance after ischemic stroke: dynamic phenotypes, neurovascular interactions, and therapeutic opportunities.

Ischemic stroke induces complex neuroimmune responses that extend beyond acute neuronal injury and involve dynamic interactions among microglia, the neurovascular unit, and peripheral immune cells. Mi...

Role of connexin 43 in hyperoxia-induced bronchopulmonary dysplasia and associated pulmonary hypertension.

Premature infants frequently require oxygen supplementation due to lung immaturity, exposing them to the risk of bronchopulmonary dysplasia (BPD), a chronic lung disease characterized by arrested alve...

Red Cell Distribution Width Predicts Mortality in Critically Ill Patients with COPD and Atrial Fibrillation: A Retrospective Cohort Study.

BACKGROUND: Critically ill patients with COPD and atrial fibrillation (AF) face a substantially poor prognosis. Given the established prognostic value of red cell distribution width (RDW) in each cond...

A Retrospective Analysis of 581 Cases of Esophagogastric Variceal Bleeding Complicated by Portal Vein Thrombosis at a Single Center.

BACKGROUND: Esophagogastric variceal bleeding (EGVB) and portal vein thrombosis (PVT) are common complications of liver cirrhosis and frequently coexist, with reported prevalence rate up to 32.5%. The...

A Study on the Clinical Phenotypes and Genetic Analysis of ENG Variants in Four Hereditary Hemorrhagic Telangiectasia Type 1 Families.

BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder primarily caused by pathogenic variants in the ENG gene, leading to clinical manifestations including...

The Landscape of Centralization in Endovascular Care for Peripheral Arterial Disease: A National Cross-Sectional Study.

IntroductionPeripheral arterial disease (PAD) is highly prevalent among cardiovascular diseases. However, the distribution and volume of endovascular diagnostic and therapeutic procedures among instit...

Delving into pyroptosis in atherosclerosis: role, mechanisms and therapeutic opportunities.

Atherosclerosis is a chronic inflammatory condition that represents the primary culprit of multiple cardiovascular diseases. Pyroptosis is a modality of programmed cell death that is elicited by, and ...

Predictors of atherosclerosis and dyslipidaemia among patients with thyroid disease: a cross-sectional analysis.

BACKGROUND: Thyroid dysfunction is a risk factor for cardiovascular disease through its effects on lipid metabolism and arterial wall remodelling. However, the relative contributions of thyroid autoim...