CAPoxy: A feasibility study to investigate multispectral imaging in nailfold capillaroscopy.

BACKGROUND: Nailfold capillaroscopy enables visualisation of structural abnormalities in the microvasculature of patients with systemic sclerosis (SSc). The objective of this feasibility study was to ...

Deep learning in Myocarditis: A novel approach to severity assessment.

BACKGROUND: Myocarditis is life-threatening in the acute phase, yet biopsy-the diagnostic gold standard-lacks an objective method to quantify cardiomyocyte damage. We developed deep learning models to...

Protein acetylation in atherosclerosis: beyond inflammation to core cellular processes and therapeutic potential.

Atherosclerosis (AS) is the leading cause of cardiovascular disease-related mortality worldwide and serves as the core pathological basis for cardiovascular events. Protein acetylation, a widespread a...

Sex differences in the association of the CRP-TyG index with coronary artery disease and long-term mortality in MASLD.

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) increases cardiovascular risk, but non-invasive tools for risk stratification are limited. The C-reactive protein-triglycer...

A Dynamic Prognosis Model of Patients with Chronic Heart Failure: A Prospective Cohort Study Using Follow-Up Data and Recurrent Neural Networks.

BACKGROUND: Prediction models for mortality risk in patients with chronic heart failure (CHF) have traditionally relied on static admission data, which restricts capturing disease dynamics. Longitudin...

From conceptual emergence to multidisciplinary expansion: a bibliometric and knowledge mapping analysis of cardiovascular-kidney-metabolic syndrome research.

BACKGROUND: The concept of cardiovascular-kidney-metabolic (CKM) syndrome has recently been introduced as an integrated framework linking heart, kidney, and metabolic disorders. However, a global over...

Survival outcomes of intensity-modulated radiotherapy combined with immunotherapy and targeted therapy for hepatocellular carcinoma with classification I-IV portal vein tumor thrombus: a propensity score matching study.

PURPOSE: The study aimed to evaluate the efficacy and safety of intensity-modulated radiotherapy (IMRT) combined with immunotherapy and targeted therapy (IT) in hepatocellular carcinoma (HCC) patients...

Development of a Prognostic Model for MACE in Atherosclerosis Based on MTHFR and Serum Markers.

Background and AimsAtherosclerosis (AS) is associated with high residual cardiovascular risk despite standard treatment. Abnormal homocysteine metabolism and MTHFR polymorphisms are involved in AS pro...

Exploring the Role of Nesprin1 in isoproterenol-induced heart failure: Insights into pathogenesis and therapeutic implications.

OBJECTIVE: This study aimed to investigate the role of Nesprin-1 in the development and progression of isoproterenol (ISO)-induced heart failure (HF) and to elucidate the underlying molecular mechanis...

Qualitative study on influencing factors of acceptance of advance care planning in patients with end-stage heart failure based on COM-B theory.

OBJECTIVE: Patients with end-stage heart failure (ESHF) face high mortality and complex decision-making needs, yet advance care planning (ACP) acceptance is insufficient in clinical practice. This stu...

Middle Meningeal Artery Embolization (MMAE) Versus Surgical Evacuation for Recurrent and Refractory Chronic Subdural Hematoma: A Systematic Review and Meta-Analysis.

BACKGROUND: Recurrent and refractory chronic subdural hematoma (cSDH) remains a significant neurosurgical challenge due to high recurrence rates and morbidity associated with repeated surgical interve...

Characterization of virus neuroinvasion, blood-brain barrier integrity and neuroinflammation following Powassan virus infection in mice.

Powassan virus (POWV) is a tick-borne Orthoflavivirus transmitted by Ixodes tick species. POWV causes fatal encephalitis in approximately 10-30% of neurological cases, and long-lasting neurological se...

Impact of breastfeeding and Mycoplasma pneumoniae co-infection on coronary artery lesions in Kawasaki disease: a retrospective cohort study.

OBJECTIVE: This study aims to investigate the impact of different feeding patterns and Mycoplasma pneumoniae (MP) infection on coronary artery lesions (CAL) in children with Kawasaki disease (KD), par...

Mitochondrial respiration and nucleotide profiling in human left internal mammary artery from CABG: a novel real-time ex vivo approach.

Mitochondrial dysfunction plays a critical role in the pathogenesis of cardiovascular and metabolic diseases. However, direct assessment of mitochondrial respiration in human vascular tissue remains t...

A Cross-Sectional Analytical Study: Prevalence and Clinical Profile of Metabolic Syndrome Among Middle Eastern, Mainly Jordanians, Cohort Presented with Atherosclerotic Cardiovascular Disease.

BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality for people living in the Middle East and North Africa (MENA) region. Accumulation of modifiable ASCVD ...

Genetic predisposition to high blood pressure and out-of-office hypertension: Insights from a population sample in liechtenstein.

Genetic predisposition is a risk factor for office hypertension. We sought to determine whether genetic predisposition identifies individuals with ambulatory daytime hypertension. 1444 participants fr...

The relationship between religious health fatalism, medication adherence, and health literacy among patients with hypertension: a cross-sectional study.

OBJECTIVES: Hypertension remains a leading global public health challenge requiring consistent self-management, particularly through medication adherence and adequate health literacy. This study aimed...

Association between hypertension prevalence and neighborhood characteristics in Japan using combined claims data and geographic information systems: a neighborhood correlation study from LIFE Study.

BACKGROUND: Hypertension is prevalent and is influenced by modifiable factors. Increasing attention has focused on community-based health promotion. However, studies on the relationship between neighb...

Recipient Left Internal Mammary Artery Salvage for Donor Coronary Artery Disease during Orthotopic Heart Transplantation: A Case Report and Focused Literature Review.

Donor coronary artery disease (CAD) can lead to the discard of otherwise suitable hearts, although selected focal lesions may be treated with concomitant revascularization. We report orthotopic heart ...

Targeted metabolomic profiling and machine learning-based prediction models for persistent atrial fibrillation: a multi-center observational study.

BACKGROUND: Atrial fibrillation (AF), one of the most common cardiac arrhythmias worldwide, carries a high risk of severe complications. Patients diagnosed with paroxysmal atrial fibrillation (PAF) ma...