Subjective sleep disturbances are associated with reduced MRI-derived perivascular-space diffusivity in multiple sclerosis.

BACKGROUND AND OBJECTIVE: Sleep modulates brain-fluid transport and glymphatic clearance. In multiple sclerosis (MS), lower diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) in...

Effect of COVID-19 on Retinal and Choroidal Microvasculature in the Pediatric Population: A Literature Review.

Backgroundand Objectives: Retinal microcirculation may serve as a surrogate marker of systemic vascular status and can be non-invasively assessed using optical coherence tomography angiography (OCTA)....

Prevalence and Angiographic Severity of Obstructive Coronary Artery Disease in Patients Presenting with a Dilated Cardiomyopathy Phenotype: A Retrospective Single-Center Cohort Study.

Background and Objectives: Identification of obstructive coronary artery disease (CAD) in patients presenting with a dilated cardiomyopathy phenotype is clinically important because it may influence e...

Racial and Ethnic Differences in Dietary Intake and Metabolic Profiles Among Adults with Heart Failure, Type 2 Diabetes, and Overweight or Obesity: A Secondary Analysis of the Pro-HEART Trial.

Background: Racial and ethnic disparities in heart failure (HF) outcomes are well documented, but little is known about dietary intake and metabolic profiles among individuals with chronic HF and over...

The Clinical Value of NT-proBNP, sST2, and Galectin-3 in the Management of Heart Failure: From Diagnosis to Dynamic Monitoring: A Narrative Review.

Heart failure management remains a critical clinical challenge. While modern neurohormonal therapies have significantly improved survival, standard clinical assessments often fail to capture the full ...

Spatial Metabolomics Reveals the Common and Compound-Specific Pharmacological Mechanisms of Two Alkaloids Against Infarcted Myocardium.

Acute myocardial infarction (AMI) is a leading cause of death worldwide, characterised by systemic inflammation and metabolic disorders. Tetrahydropalmatine (THP) and berberine (BBR) are major alkaloi...

Divergent Immune and Endothelial Responses to Insulin Resistance in Women with Polycystic Ovary Syndrome.

Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine-metabolic disorder frequently associated with insulin resistance (IR) and increased cardiovascular risk. Soluble CD40 ligand (sCD40L) and ...

Integrated Cardiopulmonary Profile as an Additive Signal in Patients Evaluated for Suspected Newly Detected Atrial Fibrillation.

BACKGROUND: Atrial fibrillation (AF) is associated with atrial remodelling, hemodynamic stress, and complex cardiopulmonary interactions. While natriuretic peptides and echocardiographic abnormalities...

Diabetes-Associated Heart Failure After Percutaneous Coronary Intervention: Molecular Mechanisms and Prospects for Early Multi-Targeted Intervention.

Diabetes mellitus (DM) is a major independent risk factor for heart failure (HF) following percutaneous coronary intervention (PCI). Metabolic disturbances associated with DM, including insulin resist...

An Optimized Protocol for Guidewire-Induced Aortic Valve Stenosis Model in Mice.

Aortic valve stenosis (AVS) is a major cardiovascular disease with increasing prevalence in aging populations, yet the scarcity of diseased valve tissue severely limits mechanistic studies and therape...

Assessment of Left Ventricular Myocardial Fibrosis and Edema in Atrial Fibrillation Using Cardiovascular Magnetic Resonance.

Progressive population aging has driven a steady rise in the incidence of atrial fibrillation (AF), making the management of its long-term prognosis an increasingly important clinical concern. In addi...

Generation of Fibrin-Based Three-Dimensional Engineered Vascular Tissues from Human Aortic Smooth Muscle Cells for Proteomic Analysis.

Vascular smooth muscle cells (SMCs) reside within the medial layer of blood vessels, where they interact with an extracellular matrix (ECM) composed of collagen, elastin, and proteoglycans to maintain...

A parabolic correlation between stress hyperglycemia ratio and 28-day mortality in US participants with diabetes and heart failure.

Current research lacks sufficient insight into the correlation between the stress hyperglycemia ratio (SHR) and 28-day mortality in critically ill patients with heart failure and diabetes. Our study a...

Clinical differences between destination therapy and bridge-to-transplant left ventricular assist device implantation: a 17-year single-center experience in Japan.

The use of left ventricular assist device (LVAD) implantation for destination therapy (DT) has been recently increased worldwide. In 2021, DT was also approved in Japan. Here, we report a single-insti...

Walking the tightrope: Mixed respiratory failure exacerbated by heart rate control and concurrent pneumonia in an elderly patient with new-onset atrial fibrillation: A case report.

RATIONALE: The interplay between new-onset atrial fibrillation (AF), heart failure (HF) with preserved ejection fraction (HFpEF), and acute infection in the elderly presents a complex clinical challen...

Superb microvascular imaging within intestinal ultrasonography predicts endoscopic ulcers in the terminal ileum of patients with Crohn's disease.

This retrospective study aimed to investigate whether superb microvascular imaging (SMI) can predict endoscopic findings in the terminal ileum of patients with Crohn's disease (CD). Patients with CD w...

Severe paravalvular leakage caused by delayed dislocation of valve prosthesis after transcatheter aortic valve replacement for rheumatic aortic valve disease: A case report.

RATIONALE: Among patients undergoing transcatheter aortic valve replacement (TAVR), serious perivalvular leakage (PVL) caused by valve dislocation is a rare but serious complication. PATIENT CONCERNS:...

Prognostic value of the platelet-to-lymphocyte ratio for recurrent hemoptysis following bronchial artery embolization in patients with ronchiectasis.

Hemoptysis is a potentially life-threatening complication commonly observed in patients with bronchiectasis, often necessitating bronchial artery embolization (BAE). However, recurrence following BAE ...

Diagnostic value of ileocolic artery and vein diameters in acute appendicitis: A retrospective observational study with contrast-enhanced computed tomography.

Acute appendicitis is a common surgical emergency characterized by right lower quadrant pain. This study investigated the diagnostic value of ileocolic artery (ICA) and ileocolic vein (ICV) diameters ...

Causal effects of atopic dermatitis and rosacea on ventricular structure and function: A Mendelian randomization study.

Rosacea and atopic dermatitis (AD) are 2 chronic inflammatory skin diseases. Studies have revealed that patients with rosacea and AD exhibit elevated risks of cardiovascular disease. However, the impa...