Exposure to heavy metals and trace elements and risk of dyslipidemia: a nested case-control analysis in rural adults.
BACKGROUND: Exposure to some conventional metal trace elements has been found to be associated with abnormal blood lipids; however, evidence for combined exposure is inconclusive. This study aimed to ...
Prognostic value of four insulin resistance indices in predicting new-onset hypertension: a retrospective cohort study.
BACKGROUND: Primary prevention of hypertension depends on early detection of high-risk individuals. Several useful risk-stratification tools are provided by lipid-glucose-insulin obtained from standar...
Balloon pressure monitoring for radial artery hemostasis after transradial coronary procedures: protocol for a randomized controlled trial.
BACKGROUND: Forearm radial artery occlusion (RAO) is a common complication after transradial coronary procedures. Traditional patent hemostasis, relying on operator-dependent assessment, results in la...
Differences in life expectancy with and without disease using reported, measured, and combined estimates for hypertension and diabetes among older adults in Colombia.
BACKGROUND: In Colombia, estimates of diabetes and hypertension prevalence differ substantially depending on the source of measurement. These differences have important implications for understanding ...
Understanding the Triple Burden of HIV, Noncommunicable Diseases, and Mental Health Conditions Among Female Sex Workers With HIV in the Dominican Republic.
ObjectivesThe purpose of this study was to determine the prevalence of type 2 diabetes, hypertension, and mental health conditions among female sex workers with HIV in Santo Domingo, Dominican Republi...
Aldosterone synthase inhibitors in uncontrolled and resistant hypertension: A phenotype-stratified systematic review and network meta-analysis of randomized trials.
BACKGROUND: Aldosterone synthase inhibitors (ASIs) have emerged as a mechanistically targeted strategy for resistant and uncontrolled hypertension; however, no head-to-head trials exist, and comparati...
Platelet extravasation in the microvasculature: an under-appreciated role for platelets.
In recent years, evidence has accumulated highlighting the presence and role of platelet extravasation - wherein platelets accumulate in tissue parenchyma - at a variety of sites throughout the body. ...
Comparative Analysis of Two Strategies for Iliac Vein Stenting: Thrombus Clearance-Assisted Versus Direct Stenting.
BackgroundThis study aimed to compare the efficacy of mechanical thrombus clearance combined with stenting versus direct stenting alone in patients with iliofemoral venous disease,, and to analyze the...
Role of macrophages in testis function.
The testis is a unique organ that simultaneously supports spermatogenesis and steroidogenesis, and it must maintain host defense against infection while suppressing excessive immune responses in an en...
Ruptured Vertebral Artery Aneurysm in a Patient with Loeys-Dietz Syndrome Type 4: A Sentinel Case Report.
Loeys-Dietz Syndrome (LDS) is a rare, autosomal dominant connective tissue disorder with an estimated prevalence of less than 1 in 100,000. LDS results from one of several genetic mutations altering t...
Metabolomics-constrained modelling reveals dominant oxidative metabolism in the Egyptian fruit bat myocardium.
AIM: The present study aimed to elucidate which pathways contribute to cardiometabolic adaptation in Egyptian fruit bats. METHODS: Utilising cardiac tissues from Egyptian fruit bats (Rousettus aegypti...
Multimodal Radiomics Model Combining HR-VWI and Clinical Features for Identifying Symptomatic Basilar Atherosclerotic Plaques.
OBJECTIVE: This study is aimed at exploring the value of a high-resolution vessel wall imaging (HR-VWI)-based radiomics approach for identifying symptomatic basilar atherosclerotic plaques. MATERIALS ...
Pre-Therapeutic Vascular Anatomical Evaluation in Penetrating Cerebrovascular Injuries: Insights from Two Cases.
Penetrating cerebrovascular injuries (PCVIs) are often life-threatening, with trauma to the carotid or vertebral arteries potentially causing severe neurological deficits. This study aimed to retrospe...
Machine learning models of inflammatory markers used in the prediction of early and late atrial fibrillation recurrence in overweight and obese patients after catheter ablation.
BACKGROUND: Inflammation is associated with atrial fibrillation (AF) recurrence after catheter ablation. This study aimed to create machine learning models of inflammatory biomarkers and clinical para...
The immune-endothelial axis in neurovascular pathophysiology: a framework for targeted interventions.
The cerebrovascular endothelium has been reconceptualized from a mere passive barrier to an active regulator of neuroimmune responses. The interaction between immune cells and endothelial cells, parti...
Endoscopic Endonasal Approach to Identify the Medial Corridor of the Cavernous Sinus: A Cadaveric Study with Clinical Correlation.
AIM: To define the existence and precise anatomical boundaries of the medial corridor (MC) within the cavernous sinus (CS), using an endoscopic endonasal transsphenoidal approach, and to correlate the...
Comprehensive Review of Antiplatelet Therapy in Secondary Prevention of Myocardial Infarction: Mechanisms, Clinical Evidence, and Future Directions.
Atherosclerotic cardiovascular disease (ASCVD), particularly myocardial infarction (MI), is the leading cause of mortality and morbidity worldwide. The pathophysiology of MI involves atherosclerotic p...
Association between pan-immune-inflammation value and clinical outcomes in critically ill patients with hyperlipidemia: An observational study.
BACKGROUND: Hyperlipidemia contributes to immune-inflammatory imbalance and poor outcomes in critical illness. The pan-immune-inflammation value (PIV), derived from neutrophil, monocyte, platelet, and...
Burden and patterns of dyslipidaemia among adult Ghanaians: A systematic review.
BACKGROUND: Dyslipidaemia is a major modifiable risk factor for cardiovascular disease and has become an increasing public health concern in sub-Saharan Africa. Rapid urbanisation, dietary transitions...
Prevalence of Hyperlipidemia and Associated Factors Among People Living With HIV Attending Care at Rugazi Health Center IV, Rubirizi District South-Western Uganda.
THE PURPOSE OF THE RESEARCH: Although antiretroviral therapy (ART) has significantly reduced HIV-related morbidity and mortality worldwide, its long-term use is increasingly associated with metabolic ...