Economic vulnerability or social inequality? A global comparative analysis of their relative impact on chronic kidney disease burden.
PURPOSE: To compare the impacts of persistent social inequality (Palma ratio) and conjunctural economic vulnerability (unemployment) on chronic kidney disease (CKD) burden and to test whether hyperten...
[Pulmonary Arterial Hypertension Impairs Duodenal Barrier Integrity in Rats].
Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease that leads to right heart failure and systemic venous congestion. Such congestion can impair multiple organs, includin...
Impact of gestational diabetes mellitus and hypertensive disorders of pregnancy on adverse pregnancy outcomes: a retrospective cohort study.
OBJECTIVE: To investigate the independent and joint effects of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) on adverse pregnancy outcomes, evaluate their potential...
Development and external validation of an interpretable machine learning model for diagnosing coronary heart disease in patients with type 2 diabetes and MASLD.
INTRODUCTION: Patients with type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) face substantially elevated coronary heart disease (CHD) risk, yet no m...
Subacute Coronary Stent Thrombosis as the Initial Presentation of Acute Myeloid Leukemia: A Case Report and Literature Review.
Subacute stent thrombosis is an uncommon but life-threatening complication of percutaneous coronary intervention (PCI). While mechanical and antiplatelet-related factors are most frequently implicated...
Validating hip- and wrist-ActiGraph accelerometer cut-points for physical activity intensities in people living with coronary heart disease.
People with coronary heart disease (CHD) are encouraged to meet the public health moderate-to-vigorous aerobic physical activity (MVPA) guidelines for secondary prevention of cardiovascular disease. H...
Predictive value of thyroid autoantibodies for coronary heart disease severity in individuals with normal thyroid function based on machine learning and SHAP interpretation.
OBJECTIVE: Assessing the severity of coronary heart disease (CHD) is critical for clinical decision-making. Thyroid autoantibodies are associated with cardiovascular disease, but their ability to pred...
Association between single-point insulin sensitivity estimator and three-vessel coronary disease: a cross-sectional study.
BACKGROUND: The single-point insulin sensitivity estimator (SPISE) is a novel surrogate marker for assessing insulin resistance in humans. Three-vessel coronary disease (TVD) remains a major challenge...
Relationship Between the Cumulative Atherogenic Index of Plasma Exposure and Incident Heart Failure.
We aimed to characterize the relationship between cumulative exposure to atherogenic index of plasma (AIP) and the risk of incident heart failure (HF) in a Chinese population.A total of 57,156 individ...
Glucose cotransporter-2 inhibitors on mortality and hospitalization in heart failure patients: a comprehensive meta-analysis.
BACKGROUND: Heart failure (HF) remains a major global health challenge, with high rates of hospitalization and mortality despite advances in therapy. Sodium-glucose cotransporter-2 (SGLT2) inhibitors,...
Hyperkalemia in Heart Failure Hospitalizations: An Underreported Contributor to Poor Outcomes and Higher Costs in Brazil.
Hyperkalemia is associated with poor prognosis in heart failure (HF), but its reporting in administrative data is likely suboptimal. The aim was to evaluate the frequency and impact of hyperkalemia IC...
Atrial Fibrillation Screening in Those with Rheumatic Heart Disease: A Narrative Policy Content Review.
BACKGROUND: Rheumatic heart disease (RHD) and atrial fibrillation (AF) are major global health burdens. AF affects up to one-third of individuals with RHD, yet clinical guidelines lack recommendations...
Effective Transcatheter Mitral Valve Repair for Reverse Remodeling in Cancer Therapy-Related Cardiac Dysfunction.
Cancer therapy-related cardiac dysfunction (CTRCD) is an emerging disease. As there is no specific treatment for CTRCD, the standard therapy for cardiac failure is typically administered. In patients ...
TIF1β Promotes Myocardial Ischemia-Reperfusion Injury by Stabilizing TRAF6 through Mediating TRAF6 SUMOylation.
Myocardial ischemia-reperfusion injury (MIRI) exacerbates myocardial damage, resulting in a further decline in heart function. Abnormally high TRAF6 expression was reported in MIRI. However, what actu...
Finerenone Attenuates Myocardial Fibrosis and Pyroptosis in Rats with Myocardial Infarction.
The mineralocorticoid receptor (MR) plays a pivotal role in cardiovascular diseases, and its overactivation contributes to heart failure (HF) progression. Finerenone (FIN), a novel nonsteroidal MR ant...
Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study.
In stable coronary artery disease, the primary goal of percutaneous coronary intervention (PCI) is symptom relief. Fractional flow reserve (FFR) and nonhyperemic pressure ratios such as resting full-c...
Global Research Trends in Cancer-Associated Atrial Fibrillation: A Bibliometric Analysis of the Cardio-Oncology Interface.
Atrial fibrillation (AF) is increasingly common in patients with cancer and is associated with higher risks of stroke, bleeding, and mortality. The growing intersection between cancer and AF presents ...
Ultra-processed foods, lifestyle management, and cardiovascular diseases.
Ultra-processed foods (UPFs) have increasingly displaced traditional diets globally and have become a significant public health concern, particularly in relation to cardiovascular (CV) diseases. UPFs ...
Single-session photon-counting CT protocol for simultaneous screening of coronary and carotid artery disease and lung pathology.
Preventive imaging for cardiothoracic risk is fragmented across separate pathways. Photon-counting CT (PCCT) may consolidate coronary, aortic-carotid, and pulmonary assessment into a single session wh...
Environmental risk factors and cardiovascular health.
Environmental risk factors-air pollution, noise, heat, chemical contamination, and light pollution-are increasingly recognized as key contributors to cardiovascular disease but remain underrepresented...