Dietary Interventions for Hypertriglyceridemia.

PURPOSE OF REVIEW: This review summarizes the pathophysiology of hypertriglyceridemia (HTG) and describes the evidence for dietary interventions in the management of HTG. RECENT FINDINGS: HTG is most ...

Nuevas perspectivas en la cardiopatía chagásica: genética, resonancia magnética y posibles alternativas terapéuticas. Una revisión narrativa.

Chagasic cardiomyopathy is the chronic manifestation of American trypanosomiasis. In endemic regions of Peru, delayed diagnosis remains a major public health concern. This review analyzes recent evide...

The role of IL-6 in hypertrophic and dilated cardiomyopathy: clinical and therapeutic implications.

Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are genetically heterogeneous myocardial disorders in which disease progression is influenced by secondary modifiers beyond structura...

Guanxinshu attenuates atherosclerosis by suppressing Galectin-3-mediated NLRP3 inflammasome activation.

Atherosclerosis (AS) is a chronic inflammatory vascular disease strongly associated with the activation of the NLRP3 inflammasome. Studies have shown that Galectin-3 (Gal-3) promotes NOD-like receptor...

The MILEPOST Framework for Integrating mHealth Into Community-Driven Interventions: Lessons Learned From a Human-Centered Design Approach in Rural Uganda.

Participatory design approaches to develop global health interventions have gained traction in recent years. However, while broad frameworks for the application of design approaches exist, literature ...

Impact for Treatment Decision-Making and Clinical Outcome of Angiography-Derived Fractional Flow Reserve.

BACKGROUND: Pressure wire-based fractional flow reserve (FFR) is the reference standard for physiologic lesion assessment but remains underutilized owing to the need for hyperemia, procedural complexi...

Photon-counting CT iodine maps for late iodine enhancement: a retrospective feasibility study of image quality and reader confidence.

OBJECTIVE: Myocardial scar assessment is clinically relevant in advanced coronary artery disease, but late iodine enhancement (LIE) CT remains limited by image contrast and validation requirements. Th...

Association between the Dietary Approaches to Stop Hypertension (DASH) diet and risk of incident heart failure and heart failure-related death: a UK Biobank cohort study.

BACKGROUND: Evidence supporting dietary interventions for heart failure (HF) prevention remains limited. The Dietary Approaches to Stop Hypertension (DASH) diet has been proposed as a cardioprotective...

Urinary Biomarkers for the Risk Assessment and Management of Heart Failure: Pearls and Pitfalls.

PURPOSE OF REVIEW: We review potential applications and pitfalls of urinary biomarkers in people with heart failure (HF). RECENT FINDINGS: Albuminuria may indicate kidney damage and guide prioritizati...

Prognostic Impact of Definite and Marginal Discordance Between Fractional Flow Reserve and Nonhyperemic Pressure Ratio.

BACKGROUND: Fractional flow reserve (FFR) and nonhyperemic pressure ratios (NHPR) can show either marginal or definite discordance. OBJECTIVES: This study sought to investigate the clinical significan...

Clinical Outcomes of Transfemoral Transcatheter Mitral Valve Replacement: Results From the CHOICE-MI Registry.

BACKGROUND: Transcatheter mitral valve replacement (TMVR) is an alternative for patients with mitral regurgitation (MR), but data on transfemoral (TF) devices are limited. OBJECTIVES: The aim of this ...

VExUS Score and Hepatorenal Congestion Improvements After Transcatheter Tricuspid Intervention: Clinical and Prognostic Insights.

BACKGROUND: Severe tricuspid regurgitation (TR) is associated with morbidity and mortality and linked to intravascular venous congestion. Venous ultrasound of the hepatic, portal, and intrarenal veins...

Nicotinamide Mononucleotide Ameliorates Myocardial Fibrosis in Diabetic Mice Possibly by Modulating SIRT3 to Deacetylate GSK3β and Thereby Reducing the Phosphorylation of Smad3.

This study aims to investigate the therapeutic potential of NMN in alleviating type 2 diabetes-induced myocardial fibrosis.The experiment was comprised of control group, diabetic group, DM + NMN inter...

Prostatic Artery Embolization: A Contemporary Review of Efficacy, Safety, and Expanding Clinical Indications.

PURPOSE OF REVIEW: Prostatic artery embolization (PAE) has emerged as a minimally invasive treatment for a spectrum of prostatic conditions. Supported by a growing body of randomized and observational...

MicroRNA-223-3p/NLRP3 axis attenuates LPS-induced sepsis-like myocardial dysfunction by suppressing cardiomyocyte pyroptosis.

BACKGROUND: Sepsis-induced cardiomyopathy (SIC), a life-threatening complication of sepsis that is characterized by myocardial inflammation and cardiomyocyte death, remains a critical clinical challen...

Spatiotemporal Strategies for Lipid-Based Nanocarriers in Stroke.

Stroke remains a leading global health problem, and effective neuroprotective and regenerative therapies are still limited. Although acute-phase reperfusion strategies have advanced, their narrow ther...

Quadricuspid truncal valve repair in a 6-year-old with severe annular dilatation.

Reintervention after truncus arteriosus repair is frequently driven by progressive neoaortic (truncal) valve regurgitation. In many patients, valve dysfunction is primarily associated with annular and...

Drug-eluting balloon angioplasty versus uncoated balloon angioplasty for peripheral arterial disease of the lower limbs.

BACKGROUND: Atherosclerotic peripheral arterial disease (PAD) can lead to chronic limb-threatening ischemia (CLTI) and limb loss. Treatments include lifestyle modifications, medications, and both open...

[A novel TPM1 variant causing Dilated cardiomyopathy in a child: A case report and literature review].

OBJECTIVE: To explore the clinical manifestations and characteristics of TPM1 gene variants causing Dilated cardiomyopathy (DCM) in children. METHODS: This study focused on a pediatric patient diagnos...

Energy Drinks and Arrhythmias in Adolescents and Young Adults: A Narrative Review of the Last Decade.

Background and Objectives: Energy drinks (EDs), widely consumed by adolescents and young adults, contain caffeine and other stimulants marketed to enhance energy and performance. ED consumption has be...