Rare types of congenital adrenal hyperplasia: report of five children with 11β-hydroxylase deficiency including pathogenic and novel CYP11B1 variants.

11β-hydroxylasedeficiency (11β-OHD) is a rare form of congenital adrenal hyperplasia caused by biallelic pathogenic variants in the CYP11B1 gene. It leads to impaired cortisol synthesis, resulting in ...

Non-steroidal anti-inflammatory drug use in patients with varying severity of coronary artery disease.

PURPOSE: We examined temporal trends in NSAID use among patients referred for evaluation of suspected coronary artery disease (CAD). METHODS: We conducted a drug utilisation study using population-bas...

Site-specific promoter hypermethylation of GPX4 in heart failure with reduced ejection fraction (HFrEF): nonlinear dose-response with hepatic and coagulation markers.

OBJECTIVE: Heart failure with reduced ejection fraction (HFrEF) remains a major global health burden characterized by progressive cardiac dysfunction and high mortality. Emerging evidence suggests tha...

The Role of miR-501-3p in Abdominal Aortic Aneurysm Progression: A Pilot Study.

MiR-501-3p, a small non-coding RNA, has been linked to vascular damage and arterial stiffness, but its role in abdominal aortic aneurysm (AAA) remains unknown. Blood exosomal microRNAs were extracted,...

What happens when public primary care is ill-prepared to respond to non-communicable diseases: a mixed-method study of diabetes and hypertension care in urban Nepal.

BACKGROUND: With rapid urbanisation in low- and middle-income countries, public primary care is struggling to respond to the growing prevalence of hypertension and diabetes, while the private sector h...

[Analysis of gene variant spectrum associated with Familial hypercholesterolemia in a regional population: A retrospective study based on exome sequencing of 15 841 cases].

OBJECTIVE: To explore the genetic variant spectrum and epidemiological characteristics of Familial hypercholesterolemia (FH) patients in a regional population. METHODS: A retrospective analysis was ca...

Recurrent Myocarditis in Young Adults: Identifying High-Risk Phenotypes and the Protective Effect of Adequate Colchicine Therapy.

Background and Objectives: Recurrent myocarditis confers a significant prognostic burden yet lacks validated predictive markers to guide risk stratification. This study aimed to identify independent c...

Bioelectrical Regulation of Vascular Endothelial Function in Atherosclerosis.

Atherosclerosis is a chronic inflammatory disease characterized by progressive vascular dysfunction and remains a leading cause of cardiovascular morbidity and mortality worldwide. Endothelial dysfunc...

Retinal Structural and Microvascular Findings on OCT and OCTA in Hemodialysis and Kidney Transplant Recipients and Their Association with Mineral Metabolism Parameters.

BACKGROUND: Chronic kidney disease (CKD) is associated with systemic microvascular dysfunction, yet the relationship between retinal changes and mineral metabolism disturbances across CKD treatment mo...

Coronary angiography findings in emergency department chest pain patients undergoing angiography despite hs-cTnT-based early rule-out angiography after hs-cTnT rule-out in ED chest pain.

BACKGROUND: High-sensitivity cardiac troponin (hs-cTn) algorithms are established for early rule-out of acute myocardial infarction, but coronary angiographic (CAG) findings in emergency department (E...

Psychological and socioeconomic impact of long-term home management on patients with left ventricular assist devices and their caregivers: a nationwide multicenter questionnaire survey.

Left ventricular assist device (LVAD) therapy requires safe long-term home management supported by patients, caregivers, and healthcare systems. In Japan, continuous caregiver availability was histori...

Successful off-label use of vascular closure devices in fully percutaneous transaxillary aortic valve implantation.

BACKGROUND: The axillary artery is an alternative access- site for transcatheter aortic valve implantation (TAVI) when femoral arteries are unfavourable. Simplified transaxillary-TAVI (TAx-TAVI) is pe...

Prevalence and burden of coronary artery disease in young adults undergoing clinically indicated coronary CT angiography.

BACKGROUND: The reported prevalence and burden of coronary artery disease in young adults varies markedly in published studies from the 1950s through 2000s but has not been evaluated in a large contem...

Left pulmonary artery sling in an infant: a vascular anomaly with a high impact on breathing.

An infant presented with persistent stridor and recurrent respiratory distress since birth. Imaging revealed a left pulmonary artery sling causing significant tracheal compression. Surgical reimplanta...

C-reactive protein and 90-day adverse clinical outcomes in acute myocarditis: a retrospective database analysis of patients requiring hospitalisation.

BACKGROUND: C-reactive protein (CRP) is commonly used to assess systemic inflammation, yet its prognostic value in acute myocarditis remains uncertain. Evidence is limited by heterogeneous populations...

Factors Modulating Mitochondrial Function after Arterial Injury: Past-to-Present Evidence for the Devising of Future Preventive and Therapeutic Strategies.

Vascular trauma can lead to adverse outcomes if remodeling is uncontrolled. Intimal hyperplasia (IH) is a key process that contributes to luminal narrowing during remodeling and is strongly influenced...

Repeatability of cerebral arteriovenous pulse wave propagation in flow-related enhancement MRI.

Flow Related Enhancement (FREE) MRI is a non-contrast technique for temporally resolved cerebral pulse-wave analysis. Clinical implementation requires proven repeatability. We aimed to evaluate the in...

Integrating RV-PA coupling and geometry-based indices into the TRI-SCORE improves prognostic assessment in tricuspid regurgitation.

BACKGROUND: Tricuspid regurgitation (TR) is a progressive and underdiagnosed condition associated with poor prognosis. Although the TRI-SCORE is a validated risk model for patients undergoing tricuspi...

Cryptogenic stroke in a young adult due to pulmonary arteriovenous malformation.

Pulmonary arteriovenous malformations (PAVMs) are rare vascular anomalies that create a right-to-left intrapulmonary shunt, allowing embolic material to bypass the pulmonary capillary filter and enter...

Sex Differences in Hypertrophic Cardiomyopathy.

PURPOSE OF REVIEW: This review summarizes contemporary evidence regarding sex-based differences in hypertrophic cardiomyopathy (HCM), including disparities in presentation, disease progression, outcom...