Targeting astrocytic Dp71 attenuates BBB disruption after traumatic brain injury through WTAP-associated m(6)A regulation of MMP2.
Blood-brain barrier (BBB) disruption is a major pathological feature of traumatic brain injury (TBI) that contributes to secondary damage and poor neurological recovery. Although astrocytes are essent...
Cardioimmunology of Myocarditis: Targeting the IL-1 Pathway.
PURPOSE OF REVIEW: Myocarditis is a heterogeneous inflammatory syndrome with aetiologies ranging from viral infection and drug hypersensitivity to systemic autoimmune/autoinflammatory disease and immu...
Which nocturnal hypoxemia parameters are associated with ambulatory blood pressure monitoring in adults with obstructive sleep apnea? A systematic review.
OBJECTIVE: Systemic arterial hypertension affects up to 50% of patients with obstructive sleep apnea (OSA) and represents one of the main modifiable cardiovascular risk factors. Hypoxemia is a recogni...
Molecular mechanisms of EPAS1 in regulating pulmonary vascular remodeling in COPD: a review.
Chronic obstructive pulmonary disease (COPD) is an incompletely reversible heterogeneous lung disease with high morbidity and mortality. Progressive worsening of dyspnea is its core clinical manifesta...
Conjoint association of gestational diabetes mellitus and hypertensive disorders of pregnancy with long-term risk of mortality: a population-based cohort study.
BACKGROUND: Gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDPs) are common maternal complications. We sought to evaluate the independent and joint association of GDM and...
Clinical outcomes and haemodynamic evolution following Perceval sutureless aortic valve implantation in high-risk aortic stenosis patients.
BACKGROUND: Sutureless aortic valve replacement (AVR) has been recognised as a potential option in the management of High-risk patients, characterised by reduced procedural times and satisfactory haem...
Totally endoscopic three-dimensional tricuspid valve repair in an adult with Ebstein's anomaly.
We report the case of a 52-year-old woman with severe tricuspid regurgitation due to Ebstein's anomaly. She underwent surgery through a 2.5 cm right minithoracotomy incision under three-dimensional en...
Root replacement after transcatheter aortic valve replacement in homograft explant.
We present the case of a young man with a prior homograft root replacement and a subsequent transcatheter aortic valve-in-valve, who presented with a root pseudoaneurysm and severe aortic regurgitatio...
Errate: Limb-Salvage Outcomes of Arterial Repair Beyond Time Limit at Different Lower-Extremity Injury Sites.
The authors wish to correct the following statement in the Abstract. The sentence: "Amputations were performed in 16 patients due to non-viable limbs, progressing infection, or muscle necrosis." shoul...
Clinical and donor-site outcomes of DIEP versus TRAM flaps in post-mastectomy breast reconstruction: a systematic review and meta-analysis.
BACKGROUND: Autologous breast reconstruction continues to be a cornerstone of post-mastectomy reconstruction, with abdominally based flaps providing reliable aesthetic and functional outcomes. Of thes...
Microsurgical clipping of paraclinoid aneurysms: a 12-year single-centre experience with surgical nuances and outcomes.
Paraclinoid aneurysms, arising from the internal carotid artery between the proximal dural ring and the posterior communicating artery, pose significant microsurgical challenges due to their proximity...
Dual-mode analysis of ischemic stroke based on urine SERS spectra and carotid B-ultrasound.
Achieving noninvasive high-frequency monitoring of ischemic stroke (IS) remains a major clinical challenge for timely intervention and precise secondary prevention. Establishing precise correlations b...
Arrhythmias in Dengue: Beyond Prevalence, Toward Pathophysiology and Clinical Risk Stratification. Reply to Iqhrammullah, M.; Rampengan, D.D.C.H. Arrhythmias in Dengue: Moving Upstream from Electrocardiographic Findings to Cardio-Hemodynamic Dysfunction. Comment on "López-Delgado et al. Arrhythmias in Dengue: A Systematic Review and Meta-Analysis. Pathogens 2026, 15, 497".
We sincerely thank Iqhrammullah and Rampengan for their thoughtful and valuable Comment [...].
Arrhythmias in Dengue: Moving Upstream from Electrocardiographic Findings to Cardio-Hemodynamic Dysfunction. Comment on López-Delgado et al. Arrhythmias in Dengue: A Systematic Review and Meta-Analysis. Pathogens 2026, 15, 497.
We read with great interest the systematic review and meta-analysis by López-Delgado et al. [...].
Blood pressure polygenic score, cardiorespiratory fitness and odds of dementia: the HUNT Study.
High blood pressure (BP) is linked to an increased dementia risk. The role of sex and the impact of cardiorespiratory fitness (CRF) on the potential association between genetic predisposition to high ...
Factors associated with the implementation of advance care planning among nurses caring for patients with heart failure: A cross-sectional survey in Japan.
BACKGROUND: Multiple barriers and facilitators affect nurses' implementation of advance care planning for patients with heart failure. However, differences in nurses' perceptions according to their ex...
Systematic Evaluation of the Nutritional Quality, Elemental Safety, and Preventive Effects of Perilla Seed Oil on Hyperlipidemia and Gut Microbiota Dysbiosis in High-Fat Diet-Fed Rats.
Background: Perilla seed oil (PSO) is a high-nutritional-value oil and widely used in functional foods, and derives from the mature seeds of Perilla frutescens. This study aimed to systematically eval...
Follistatin Mitigates Atherosclerosis Through Activation of Arginine Metabolism and Adipose Browning.
Follistatin (FST) binds to and neutralizes members of the transforming growth factor-beta (TGF-β) superfamily, thereby regulating diverse physiological processes, including regulation of skeletal musc...
Effects of Prolonged Normobaric Hypoxia and Norepinephrine on the Rat Heart-Can They Be Reversed by Normoxic Recovery?
Previous studies on rats showed a deterioration of left ventricular (LV) function and myocardial injury characterized by oxidative/nitrosative stress, PARylation, and apoptosis in the heart after thre...
Outcomes after heart valve surgery for adult patients with active Enterococcus faecalis infective endocarditis: a 20-year, national, retrospective, observational cohort study in Aotearoa New Zealand.
BACKGROUND: The post-surgical duration of antibiotic treatment for patients with active infective endocarditis (IE), receiving heart valve surgery is uncertain. We aimed to assess the antibiotic treat...