Radiation dose optimization in coronary CT angiography clinical application of absolute phase gating in patients with atrial fibrillation.

BACKGROUND: Atrial fibrillation (AF) poses significant challenges for coronary CT angiography (CCTA) due to R-R interval variability, often necessitating high radiation dose protocols. Absolute phase ...

Multimodal ophthalmic imaging in the search for the association between subretinal drusenoid deposits and systemic vascular comorbidity with metabolic dysregulation in age-related macular degeneration progression.

INTRODUCTION: Age-related macular degeneration (AMD) is increasingly linked to systemic cardiovascular and metabolic dysfunction as well as cerebral small vessel disease. Subretinal drusenoid deposits...

Characteristics of non-culprit coronary artery lesions assessed by intravascular ultrasound in patients with ST-segment elevation myocardical infarction.

BACKGROUND: Non-culprit coronary lesions are increasingly recognized as an important source of recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI). Intr...

The Prognostic Value of CRP/Albumin Ratio in Prediction of Limb Salvage in Patients with SFA Lesion According to TASC II Classification After Endovascular Treatment: A Pilot Study.

BACKGROUND: Higher systemic inflammation may portend worse limb outcomes after endovascular therapy (EVT). We assessed whether the pre‑procedural C‑reactive protein/albumin ratio (CAR) predicts major ...

Left atrial strain and right ventricular mechanics in advanced heart failure: a prospective observational study.

PURPOSE: Left atrial reservoir strain (LASr) is an established marker of atrial dysfunction and elevated filling pressures in heart failure; however, its role in mediating downstream right ventricular...

Defining reference intervals for submaximal cardiopulmonary exercise testing-derived gas-exchange derived pulmonary capacitance in older adults.

BACKGROUND: Gas-exchange derived pulmonary capacitance (GXCAP) is a non-invasive index of pulmonary arterial capacitance obtainable from submaximal cardiopulmonary exercise testing (CPET), but referen...

A new in silico model to precisely design focused ultrasound brain therapies.

BACKGROUND: Focused ultrasound (FUS) combined with microbubbles enables transient and noninvasive blood-brain barrier (BBB) opening, facilitating targeted drug delivery. However, accurate treatment pl...

Polygenic Risk Scores for Incident Dementia in the Multi-Ethnic Study of Atherosclerosis.

Over 75 Alzheimer's disease (AD) and dementia-associated variants have been identified through genome-wide association studies, but the utility of polygenic risk scores (PRS) for predicting AD and dem...

Challenges of heart failure treatment in patients with chronic kidney disease: A call to action.

Heart failure (HF) is one of the most common and consequential conditions encountered in clinical practice. It frequently coexists with chronic kidney disease (CKD), a highly prevalent and economicall...

The Cardiac Safety of High-Dose Propranolol Used to Treat Severe Behaviors With Autism Spectrum Disorders.

BACKGROUND: Aggression and self-abusive behaviors are serious problems in the developmentally disabled. Several medications have shown efficacy, but many individuals remain inadequately treated or int...

Simulation-Based Training for New-Onset Symptomatic Rapid Atrial Fibrillation Among Prehospital Health Care Providers.

OBJECTIVE: Atrial fibrillation is the most common cardiac arrhythmia in clinical practice making proficient diagnosis and treatment vital to patient outcomes. The increased incidence of new-onset symp...

A Non-Channel Function of CFTR: Attenuating Mitochondrial Oxidative Stress and Cardiomyocyte Senescence via Stabilization by USP45.

Cardiomyocyte senescence drives cardiovascular disease, underscoring the need to define its molecular mechanisms. The role of cystic fibrosis transmembrane conductance regulator (CFTR) ion channel in ...

Cellular Heterogeneity During Arterial Aging.

Arterial aging is a major risk factor for cardiovascular disease and is associated with progressive changes in vascular structure and function, including arterial stiffening, reduced elasticity, extra...

Cardioprotective Effect of Aloin Against Ischemia/Reperfusion Injury: Experimental and Computational POM Approaches.

This study investigates the antihypertensive, antioxidant, and cardioprotective effects of Aloin following Langendorff rat isolated heart technique, the main bioactive compound of Aloe vera L., using ...

Mex-3 RNA-binding family member A limits macrophage ferroptosis-associated injury linked to the SLC7A11/GPX4 pathway in diabetic atherosclerosis.

BACKGROUND: Diabetes accelerates atherosclerotic plaque expansion and loss of stability, but the plaque-resident mechanisms through which the diabetic milieu promotes macrophage lipid-oxidative injury...

A Randomized Trial of Interval Likelihood Ratios for Clinical Decision-Making.

BACKGROUND: Dichotomized reporting of diagnostic test results may oversimplify test characteristics. Interval likelihood ratios (ILRs), test characteristics across a range of values, offer a nuanced a...

Chronic Bladder Ischemia Enhances Mechanosensitive Afferent C-Fiber Activity: Insights From a Newly Developed Female Rat Model.

OBJECTIVES: This study aimed to develop and validate an atherosclerosis-induced chronic bladder ischemia (CBI) model in female rats and to evaluate mechanosensitive single-unit afferent activity (SAA)...

Outcomes of Liver Transplant Versus Partial Hepatectomy for Perihilar Cholangiocarcinoma Patients Requiring Arterial Reconstruction.

BACKGROUND AND AIMS: Liver resection (LR) and orthotopic liver transplantation (OLT) are therapeutic options for locally advanced perihilar cholangiocarcinoma (pCCA) requiring hepatic artery reconstru...

An Outflow Tract Myocardium-Specific Enhancer at the Sema3c Locus During Heart Development.

Sema3c is specifically expressed in the cardiac outflow tract (OFT) of the developing mouse heart and has been implicated in OFT polarization and great artery formation. However, the regulatory basis ...

A 12-week Exercise Intervention Among Older Adults With Chronic Coronary Syndrome: Changes and Associations of Movement Behaviors and Cardiovascular Risk Factors.

Physical activity (PA) is key to improve the prognosis of patients with chronic coronary syndrome (CCS). This study investigated changes in movement behaviors (MB), obesity markers, cardiorespiratory ...