Macrophage Plasticity and Immune Remodeling in Ischemic Heart Failure.
Macrophages, as central effectors of innate immunity, play context-specific and time-dependent roles in myocardial infarction (MI) and in the pathogenesis of ischemic heart failure (HF). Their plastic...
Hypertension-Mediated Organ Damage: Pathophysiological Mechanisms, Clinical Consequences, and Implications for Early Risk Stratification.
Hypertension-mediated organ damage (HMOD) represents a critical and dynamic stage on the cardiovascular continuum, serving as the primary mechanistic link between sustained arterial pressure elevation...
What does it mean to win? Interpreting hierarchical kidney outcomes in hypertension trials.
Hierarchical composite kidney outcomes analyzed using win statistics prioritize important events while avoiding some limitations of traditional composite end points. Liu et al. apply this approach to ...
Preoperative MRI Model for Predicting Inferior Vena Cava Wall Invasion in Renal Cell Carcinoma with Tumor Thrombus.
Purpose To develop and evaluate a preoperative MRI-based model for predicting inferior vena cava (IVC) wall invasion in renal cell carcinoma (RCC) with IVC tumor thrombus (IVCTT) and to compare its pe...
Long-term Complications of Pulmonary Embolism: Which Is the Optimal Follow-Up?
Pulmonary embolism (PE) is associated with substantial long-term morbidity that extends past initial diagnosis. Patients diagnosed with PE face risks of chronic thromboembolic pulmonary hypertension, ...
Recent Advances in Pulmonary Hypertension Management.
Significant progress has been made in the management of pulmonary hypertension (PH), and especially pulmonary arterial hypertnesion (PAH), over the last 3 decades. Recent advances in the diagnosis, ri...
The Role of Machine Learning and Artificial Intelligence in Drug Discovery and Clinical Care of Pulmonary Hypertension.
Pulmonary hypertension (PH) is a severe and oftentimes fatal disease with a high degree of clinical variability. Its complexity necessitates a multifaceted approach, with clinical and prognostic resul...
Portopulmonary Hypertension: Current Perspectives.
Portopulmonary hypertension (PoPH) is a form of pulmonary arterial hypertension in the setting of cirrhotic or noncirrhotic portal hypertension. It is a significant complication affecting approximatel...
Exercise Training and Cardiac Rehabilitation in Chronic Thromboembolic Pulmonary Hypertension.
Patients with chronic thromboembolic pulmonary hypertension (CTEPH) were traditionally advised against exercise training, based on unsubstantiated concerns that exercise-induced increases in pulmonary...
Long-term Complications of Venous Thromboembolism: A Practical Guide.
Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) of the lower limbs and pulmonary embolism (PE), is associated with long-term functional impairment comparable to that seen after acu...
Advances in the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension.
Chronic thromboembolic pulmonary hypertension (CTEPH) refers to precapillary pulmonary hypertension. Its diagnosis is rising since the pathophysiology is better understood and screening is more rigoro...
Pulmonary Hypertension: From Molecular Pathways to Patient Care.
Pulmonary hypertension (PH) is a heterogeneous condition defined by an increase in mean pulmonary arterial pressure over 20 mm Hg diagnosed through right heart catheterization. Its global prevalence i...
The Interplay of Heart Failure and Pulmonary Embolism: A Comprehensive Review.
Heart failure (HF) is strongly associated with venous thromboembolism (VTE) through mechanisms of hypercoagulability, venous stasis, and endothelial dysfunction. Patients with HF who develop pulmonary...
PROSTACYCLIN ANALOGS AND DIABETIC RETINOPATHY OUTCOMES IN PATIENTS WITH PULMONARY HYPERTENSION : A Cohort Analysis.
PURPOSE: The aim of this study was to evaluate the association between prostacyclin analog (PCA) therapy and the long-term incidence of diabetic retinopathy (DR) in patients with diabetes and pulmonar...
Evaluating the Efficacy and Utility of Preoperative Computed Tomography Angiography in Perforator Flap Surgeries: A Systematic Review and Meta-Analysis.
BACKGROUND: Deep inferior epigastric artery perforator (DIEP) flaps are widely used in autologous breast reconstruction and increasingly favored due to superior patient-reported outcomes. Preoperative...
High-Frequency Low-Tidal Volume Ventilation and Catheter-Tissue Interaction During Pediatric Radiofrequency Ablation: A Prospective Observational Study.
OBJECTIVES: To evaluate the association between ventilation strategy and catheter-tissue interaction, lesion characteristics, and procedural metrics during pediatric supraventricular tachycardia ablat...
Recipient Vessel Selection in Free Flap Phalloplasty: A Systematic Review and Single-Arm Meta-Analysis.
BACKGROUND: Selection of recipient vessels in phalloplasty is challenging due to the absence of adequate vessels in the immediate proximity. There is no consensus on the appropriate vessel selection. ...
Nebivolol Protects the Thoracic and Abdominal Aorta and Their Perivascular Adipose Tissue From the Differential Detrimental Effects of Obesity.
The effects of obesity on the vasculature and perivascular adipose tissue (PVAT) function vary according to the vascular territory. Nebivolol is a third-generation β-blocker that exerts vasculoprotect...
Etiology, Management, and Outcomes of Hospitalized Heart Failure Patients: A Single-Center Study.
OBJECTIVES: To describe the clinical characteristics, etiologies, management patterns, and outcomes of hospitalized heart failure patients in a tertiary care military hospital in United Arab Emirates ...
Social Frailty in Heart Failure: A Scoping Review of Prevalence, Impact and Critical Knowledge Gaps.
BACKGROUND: Social frailty is increasingly recognised among people living with heart failure and is linked to a range of clinical and psychosocial risk factors, with significant implications for healt...