Association of Triglyceride-Glucose Index, Triglyceride/HDL Cholesterol Ratio and Metabolic Score for Insulin Resistance With Asymptomatic Organ Damage in Previously Untreated Patients With Hypertension.

We aimed to examine the association between insulin resistance (IR) and target organ damage (TOD) in patients with hypertension. Three indices of IR (Triglyceride-Glucose index: TyG; triglyceride-to-H...

Atrial Fibrillation and Lipid-related Indices in Japanese Men: An Age-matched Case-control Study.

BACKGROUND/AIM: Atrial fibrillation (AF) is associated with cardiovascular risk factors. Although certain lipid-related indices, including the ratio of low-density lipoprotein (LDL) cholesterol to hig...

Exploring mechanisms for reversal of flow in tunicate hearts.

Ascidians, a class of tunicates, are marine invertebrates with valveless, tubular hearts. Recent experiments suggest that the hearts of Ciona robusta have two distinct pacemakers, one at each end of t...

Quantitative optical coherence tomography angiography analysis of retinal capillary plexuses in diabetic eyes: Impact of phakic and pseudophakic status.

BACKGROUND: Optical coherence tomography angiography (OCTA) has revolutionized the evaluation of retinal microvasculature by enabling noninvasive quantification of capillary networks and the foveal av...

Minute-level ECG-derived autonomic dynamics around obstructive apnea events: A peri-event analysis of the PhysioNet apnea-ECG database.

BACKGROUND: Obstructive sleep apnea (OSA) is linked to arrhythmia and cardiovascular morbidity, but the cardiac response to individual obstructive events is incompletely characterised at minute-scale ...

RNF113A Protects Against Sepsis-Induced Myocardial Injury via Activation of the Keap1/Nrf2 Axis to Reduce Ferroptosis.

Sepsis-induced myocardial injury (SIM) is a common complication of sepsis that can cause high morbidity and mortality. However, the molecular mechanisms underlying SIM have still not been fully elucid...

Potassium Imbalance in Patients with Hypertension and Acute Haemorrhagic Stroke in a Tertiary Level Hospital of Bangladesh.

Acute haemorrhagic strokes are most common in people with hypertension, which causes high morbidity and mortality in Bangladesh. In this study, we investigated that whether serum potassium level is as...

Association of On-admission Serum Uric Acid Level with Short Term Outcome of Patients with Chronic Heart Failure.

In chronic heart failure (CHF), serum uric acid (SUA) levels rise primarily due to increased production, partially due to decreased excretion, or both elevated uric acid levels are a sign of developin...

Prognostic Significance of Right Bundle-Branch Block Associated with Acute ST Elevation Myocardial Infarction.

Right bundle-branch block (RBBB) during acute ST elevation. Known about how RBBB influences the prognosis of acute STEMI in the background of changing demography. The main objective of the study was t...

Interrelations of aortic spring function, cardiovascular disease risk factors, and left ventricular diastolic function: The Framingham Heart Study.

Mechanical twisting and untwisting of the left ventricle as well as abnormal hemodynamic aortic-ventricular coupling are recognized as contributors to left ventricular diastolic function. However, ene...

Dapagliflozin Improves Mitochondrial Function to Reduce the Risk of Atrial Fibrillation in a High-Glucose Environment by Activating the AMPK/PGC-1α/SIRT3 Signalling Pathway.

BACKGROUND: Type 2 Diabetes Mellitus (T2DM) and AF (Atrial Fibrillation) frequently coexist, amplifying cardiovascular risks via shared mitochondrial dysfunction involving metabolic dysregulation, oxi...

Application of conventional ultrasound-based carotid grading system in assessing disease activity and monitoring progression in Takayasu arteritis.

OBJECTIVE: This study aimed to evaluate and validate the utility of a conventional ultrasound-based carotid grading system in assessing disease activity in Takayasu arteritis (TA) with carotid artery ...

Insights into Matrix Metalloproteinase-2 Genotypes, Smoking, Alcohol Drinking, Hypertension and Renal Cell Carcinoma in Taiwan.

BACKGROUND/AIM: Renal cell carcinoma (RCC) accounts for more than 90% of kidney malignancies worldwide. Matrix metalloproteinase-2 (MMP-2) has been reported to be dysregulated in multiple cancers. How...

Novel strategies to overcome the blood-brain barrier in triple-negative breast cancer brain metastases.

Triple-negative breast cancer-the most aggressive breast cancer subtype-has a high propensity for brain metastases, with limited treatments and poor prognosis. The blood-brain barrier, long viewed as ...

Microvessel Maturation Correlates With Doppler Ultrasound Indices and Vascular Invasion in Follicular Thyroid Tumors.

BACKGROUND/AIM: Preoperative assessment of vascular invasion in follicular thyroid tumors remains challenging. Although quantitative Doppler indices, such as the resistive index (RI) and pulsatility i...

Electrocardiographic Repolarization Changes Following Orchiectomy: Insights Into QT Interval Prolongation and Clinical Implications.

INTRODUCTION: Sex steroid hormones influence ventricular repolarization and QT interval duration. Testosterone has been associated with shorter QT intervals, whereas androgen deprivation may prolong r...

Improving anxiety screening for adults with hypertension: An integrative review.

BACKGROUND: There is very limited literature specifically addressing anxiety and hypertension. This integrative review evaluated existing research on the topic of appropriate measurement of anxiety le...

The Use of Ambulatory Blood Pressure Monitoring in Pediatric Heart Transplant Recipients.

BACKGROUND: Ambulatory blood pressure monitoring (ABPM) is the gold-standard non-invasive test for diagnosing arterial hypertension; however, it remains understudied in pediatric heart transplant reci...

Heart Failure With Preserved Ejection Fraction-Like Phenotype in Coronary Artery Disease and Obstructive Sleep Apnea: Insights From the RICCADSA Cohort.

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is closely linked to aging and cardiometabolic risk factors and frequently coexists with obstructive sleep apnea (OSA). We aimed to i...

Idiopathic thoracic aortic aneurysm in a dog with 2:1 atrioventricular block.

A 14-year-old castrated male spitz dog was presented with intermittent coughing. Physical examination revealed bradycardia and a grade 3/6 left apical systolic murmur. Thoracic radiographs demonstrate...