Phosphoproteomics distinguishes disease-specific mechanisms for human phospholamban cardiomyopathy reversible by RNA therapy.
Phospholamban (PLN) p.Arg14del (R14Δ/+, also known as R14del) is a pathogenic variant that causes inherited cardiomyopathy. RNA therapy improves cardiac function and survival in murine PLN R14Δ/+. How...
Patient Engagement Strategies for Implementing Evidence-Based Care in Atherosclerosis.
PURPOSE OF THE REVIEW: Despite continuing therapeutic advances in cardiovascular disease, it remains a leading cause of morbidity and mortality in the US. The current challenge is not the development ...
Intervening at the microbial crossroads: targeting inflammation across the oral-gut-reproductive microbiome crosstalk in atherosclerosis.
Despite the increasing burden of mortality due to cardiovascular disease, the traditional risk factors fail to explain the complexity of the pathology of cardiovascular disease, especially in the cont...
Subsequent Hypertension's Mediation of the Association Between Sleep Duration Trajectories and New-Onset Cardiovascular Disease: Population-Based Cohort Study.
BACKGROUND: Prior research has rarely explored the link between sleep duration trajectories and cardiovascular disease (CVD) either in cross-sectional or longitudinal data. OBJECTIVE: We aimed to anal...
SGLT2 inhibitor dapagliflozin treats heart failure with preserved ejection fraction via the SIRT1/PGC-1α pathway.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have demonstrated clinical benefits in heart failure with preserved ejection fraction (HFpEF), yet the underlying mechanisms remain poorly defined. G...
Beyond the Powerhouse: Mitochondrial Crosstalk as a Master Regulator of Cardiac Metabolic Homeostasis and Failure.
Mitochondrial dysfunction has long been recognized as a central driver of heart failure (HF) pathogenesis, and emerging evidence highlights that impaired mitochondrial communication, rather than merel...
[Modified Valsalva maneuver induced an asymptomatic polymorphic ventricular tachycardia].
Paroxysmal supraventricular tachycardias (PSVT), including atrioventricular nodal re-entry tachycardia (AVNRT), are commonly treated with vagal maneuvers. The modified Valsalva maneuver, combining for...
Sudden cardiac death (SCD) is a major public health problem worldwide. Despite many advances in the care of sudden cardiac arrest (SCA), 90% of individuals with SCA do not survive. A major challenge i...
Introduction of the three-vessel trachea view to the second trimester foetal anomaly screening programme increased detection of right (RAA) and double (DAA) aortic arch. Aim was to investigate inciden...
Role of Inflammatory Biomarkers in Peripheral Arterial Disease: A Comprehensive Review of Prognostic and Therapeutic Implications.
Background: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis characterized by chronic inflammation, endothelial dysfunction, and high residual risk of major adverse cardi...
Effect of Latilactobacillus curvatus HY7601 and Lactiplantibacillus plantarum KY1032 on Serum Triglyceride Levels and the Gut-Metabolic Axis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Background/Objectives: Hypertriglyceridemia is a critical cardiovascular risk factor, and the probiotic combination of Latilactobacillus curvatus HY7601 and Lactiplantibacillus plantarum KY1032 (HY+KY...
LightGBM-Based Classification of Heart Failure Phenotypes Using Morpho-Energy Features from High-Resolution ECG.
Heart failure (HF) remains a major global health challenge, necessitating accurate yet accessible diagnostic tools. While the left ventricular ejection fraction (LVEF) is the primary metric for classi...
Effect of L-Citrulline Supplementation on Endothelial Function and Body Composition in Post-COVID-19 Syndrome: A Randomized Clinical Trial.
Background: Post-COVID-19 syndrome is associated with endothelial dysfunction (ED) and various sequelae, particularly in individuals who experienced critical illness during the acute phase, affecting ...
Heart-Type Fatty Acid-Binding Protein (H-FABP) as a Candidate Adjunctive Biomarker for Immune Checkpoint Inhibitor-Related Cardiotoxicity: Linking Early Immune-Metabolic Myocardial Injury with Translational Cardio-Oncology.
Immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape of oncology but are increasingly associated with cardiovascular immune-related adverse events (irAEs), including myocardi...
Pilot study of the use of ezetimibe in dogs with hyperlipidemia.
The aim of this study was to evaluate the tolerance and efficacy of ezetimibe in reducing cholesterol and/or triglycerides in dogs with hyperlipidemia. Twenty-three dogs with hyperlipidemia were rando...
Dual valve Achromobacter endocarditis in a long-term acute care unit: a case report and review of the literature.
BACKGROUND: Achromobacter xylosoxidans is an opportunistic, gram-negative organism that primarily affects immunocompromised individuals or those with indwelling medical devices. Although generally con...
Pragmatic trial assessing polygenic risk driven statin therapy for cardiovascular disease prevention: study protocol for the EE-PRS trial.
INTRODUCTION: Atherosclerotic cardiovascular disease (ASCVD) continues to be a leading cause of preventable death globally. Polygenic risk scores (PRS) offer a way to detect individuals at higher rela...
Rentrop collateral grade predicts myocardial viability in chronic total occlusion on cardiac magnetic resonance.
BACKGROUND: Chronic total occlusion (CTO) often triggers collateral coronary development, yet the relationship between angiographically graded collaterals and myocardial viability remains incompletely...
Anesthetic management of a pregnant patient with right ventricular outflow tract ventricular tachycardia undergoing cesarean section.
Idiopathic ventricular tachycardia arising from right ventricle outflow tract (RVOT-VT) is an uncommon, catecholamine-sensitive form of VT occurring in the absence of structural heart disease and may ...
Children exposed to hydroxychloroquine in utero show no signs of retinal toxicity at age 5.
OBJECTIVE: Limited examinations from prior studies support the absence of retinal toxicity in infants exposed to maternal hydroxychloroquine (HCQ). However, the infant retina does not have adult morph...