Ion-Responsive Microneedles Delivering Subtype-Specific Mitochondrial Extracellular Vesicles from HEY1⁺ Cardiomyocytes for Cardiac Repair in Bama Minipigs with Myocardial Ischemia-Reperfusion Injury.

The pathogenesis of myocardial ischemia-reperfusion (MI/R) injury is intricately linked to mitochondrial dysfunction occurring during both the ischemic and reperfusion phases. Through single-cell tran...

NOD1 is a key mediator of atrial myopathy in heart failure.

UNLABELLED: Heart failure (HF)-associated atrial myopathy is driven by complex and poorly understood mechanisms. Emerging evidence suggests that innate immune components contribute to atrial remodelin...

Ultrasound targeted fatty acid nitroalkene-containing lipid nanoparticles attenuate inflammation and reverse myocardial fibrosis.

RATIONALE: Myocardial ischemia-reperfusion injury (MIRI) induces oxidative stress and inflammatory signaling that drive fibroblast activation, myocardial fibrosis, and progressive cardiac dysfunction,...

A Brain-Targeted Organophosphorus Hydrolase Fusion Protein Mediated by Angiopep-2 Neutralizes Central Organophosphates and Alleviates Neurotoxicity.

PURPOSE: Organophosphates (OPs) exert neurotoxicity by inhibiting acetylcholinesterase (AChE) activity, leading to acetylcholine accumulation, excessive nervous system stimulation, and even fatal outc...

Efficacy of an Integrated Nursing Protocol for the Management of Postoperative Upper Limb Circulatory Complications Following Transradial Coronary Intervention.

ObjectiveThe aim of this study was to assess the effectiveness of an integrated, evidence-based nursing protocol combining traditional Chinese and Western medicine for the management of upper limb cir...

Determinants of Digital Health Literacy Among Hypertensive Adults: A Community-Based Cross-Sectional Study.

OBJECTIVE: Digital health literacy (DHL) is a critical component for the effective self-management and secondary prevention of hypertension. However, the multi-level determinants of DHL in community s...

[Impairment of retinal and choroidal blood flow autoregulation in preeclampsia].

Preeclampsia is a leading cause of maternal and perinatal mortality, which makes the search for methods of early preclinical diagnosis highly relevant. Ocular microcirculation, owing to its similarity...

Integrated Network Pharmacology and Experimental Validation Approach to Systematically Elucidate the Cardioprotective Mechanisms of Shengmai Injection.

Core to advancing the study of traditional Chinese medicine (TCM) mechanisms is the integrated "computational prediction-experimental verification" strategy, which enables the precise identification o...

An Improved Brain-Penetrating Nanoformulation of the VIPR2 Antagonist Peptide KS-133 for Treating Cognitive Impairment in Schizophrenia.

In 2024, we reported a brain-penetrant formulation of the vasoactive intestinal peptide receptor 2 (VIPR2) antagonist peptide KS-133 that mitigated cognitive dysfunction in the VIPR2 hyperactivation m...

Association between occupational sedentary behavior and metabolic syndrome and related diseases in males: A cross-sectional study.

BACKGROUND: Prolonged occupational sedentary behavior has become a prevalent norm in workplaces, posing significant health risks. However, there is a scarcity of studies on the association between occ...

Differences in clinical features and prognosis between hypertriglyceridemia and other causes of acute pancreatitis: a dual perspective based on metabolic disorders and inflammatory response.

BACKGROUND: To investigate the clinical features and prognosis of acute pancreatitis (AP) with different etiologies. METHODS: A total of 242 patients with AP admitted to the First Affiliated Hospital ...

Awareness, attitudes, and barriers toward Transthyretin Amyloid Cardiomyopathy in Latin America: A questionnaire-based cross-sectional study.

BACKGROUND: Cardiac Amyloidosis (CA), specifically Transthyretin Amyloid Cardiomyopathy (ATTR-CM), is an under-recognized, progressive, and fatal disease. Comprehensive primary data describing awarene...

Successful rescue therapy with eculizumab for probable tislelizumab-related MMM overlap syndrome with dual positivity for anti-acetylcholine receptor and anti-titin antibodies: a case report and literature review.

BACKGROUND: While immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, they can trigger diverse immune-related adverse events (irAEs). Among these, ICI-related myocarditis, myosit...

Potentials, barriers, and strategies for integrating tuberculosis, diabetes mellitus, and hypertension case management: A scoping review.

BACKGROUND: The coexistence of tuberculosis (TB) with other chronic diseases, such as diabetes mellitus (DM) and hypertension, presents a growing challenge for efforts to end TB due to the complex int...

Predictors of complicated course of acute myocardial infarction with ST-segment elevation in patients with obesity, overweight and normal body weight.

OBJECTIVE: Aim: The aim of the study was to clarify the influence of smoking and other risk factors (RFs) on the occurrence of complications in patients with normal body weight, overweight (OW) and ob...

Case Report: Recurrent coronary in-stent restenosis as the primary manifestation of non-criteria antiphospholipid syndrome confirmed by anti-phosphatidylserine/prothrombin IgM antibodies.

BACKGROUND: A 47-year-old female with no traditional CAD risk factors developed recurrent in-stent restenosis (ISR) one year after LAD stenting. She had recurrent pregnancy loss, chronic urticaria, an...

Safety and efficacy of dual-axis rotational vs standard coronary angiography: meta-analysis.

The objective is to compare the safety and efficacy of dual-axis rotational coronary angiography (DARCA) with standard coronary angiography (SA). We performed a systematic review and meta-analysis com...

Data-driven atherosclerotic plaque profiles from QAngio-CT associated with functional impairments assessed with PET-CT.

OBJECTIVE: Although coronary artery disease (CAD) involves progressive atherosclerotic plaque dysfunction, further characterization of different cluster profiles and their impact on myocardial functio...

Integrated NEK7-inflammasome and platelet transcriptomic signature generates mechanistic hypotheses in heart failure.

BACKGROUND: The relationship between NEK7-NLRP3 inflammasome activation and elevated platelet activity in the progression of heart failure (HF) is not well understood. Additionally, a comprehensive ge...

Mechanisms of nephroprotective action of sodium-glucose cotransporter type 2 inhibitors.

OBJECTIVE: Aim: To study the potential mechanisms underlying the beneficial nephroprotective effects of sodium-glucose cotransporter 2 (SGLT-2) inhibitors. PATIENTS AND METHODS: Materials and Methods:...