[Research progress in Lyme carditis].

莱姆病是由蜱虫传播、伯氏疏螺旋体感染所致的自然疫源性疾病，莱姆病心脏炎是其严重的心血管并发症，发生率为1%~10%。该病以房室传导阻滞及心肌炎症为主要表现，主要累及心脏传导系统，可引发心律失常甚至猝死。诊断需结合流行病学史、临床症状与血清学检测，推荐采用“酶免疫分析联合C6肽检测、心电图初筛，蛋白免疫印迹法最终确证”的流程，并注意与病毒性心肌炎等疾病鉴别。2024年美国疾病控制与预防中心/欧洲心脏...

[Research progress of mitochondria-associated endoplasmic reticulum membranes in sepsis-induced cardiomyopathy].

线粒体相关内质网膜（MAMs）是线粒体与内质网通过物理接触形成的特殊功能结构域，介导两大细胞器间的物质转运与信息交流，在空间分布与生物学功能上均实现高度偶联。脓毒症心肌病是脓毒症进程中出现的可逆性心肌功能损伤。现有研究表明MAMs可通过调控钙信号传导、自噬、线粒体动力学、内质网应激及炎症等关键通路，参与脓毒症心肌病的发生与发展。该文就MAMs的结构特征、生物学功能及其在脓毒症心肌病中的作用机制作一...

[Correlation analysis between cumulative blood pressure load and arterial stiffness in midlife: a 36-year follow-up study].

Objective: To explore the association between cumulative blood pressure load from childhood to midlife and the risk of arteriosclerosis in midlife. Methods: This study was based on the Hanzhong Childr...

[Related factors and prediction model of recurrent in-stent restenosis after DES].

Objective: To investigate the factors associated with recurrent in-stent restenosis (ISR) after drug-eluting stent (DES) implantation and to establish a screening model. Methods: This cross-sectional ...

[The dual effects and therapeutic prospects of ketone bodies in atherosclerosis].

动脉粥样硬化是一种因代谢紊乱引发的慢性炎症性疾病，涉及高血压、血脂紊乱、糖尿病等多个因素。传统观念认为过高的酮体会加速动脉粥样硬化的进程，但近期研究揭示了酮体的复杂作用。在动脉粥样硬化的发展过程中，酮体一方面可以为受损血管提供能量底物，另一方面在特定条件下发挥抗炎和抗氧化作用，抑制动脉粥样硬化的进展。该综述将深入分析酮体在动脉粥样硬化中的双重影响及其潜在机制，以期为动脉粥样硬化的临床治疗和疾病管理...

[A case of hereditary hemochromatosis with multi-organ involvement presenting primarily as heart failure].

遗传性血色病属于常染色体遗传性铁代谢异常疾病，发病核心机制为铁调素合成不足或功能缺陷，导致肠道铁吸收调控紊乱、机体铁负荷过载并在多器官过度沉积，引发相应脏器功能损害。该病起病隐匿，临床表现缺乏特异性，易被漏诊、误诊，多数患者常在进展至终末期器官并发症时才得以明确诊断。该文报道1例以心力衰竭为主要表现的2型遗传性血色病青年患者，旨在增强临床医师对该病的认知与识别能力，促进疾病早期诊断与系统性管理。.

[Triangular mesh reconstruction based on CT angiography in the diagnosis and treatment of left ventricular subepicardial aneurysm rupture following radiofrequency ablation for premature ventricular contractions: a case report].

左心室心外膜下室壁瘤是射频消融治疗室性早搏罕见但严重的并发症，可能破裂导致急性心脏压塞甚至猝死。该文报告1例59岁女性患者，因症状性室性早搏接受射频消融治疗，术中发生心脏压塞，通过联合应用经胸超声心动图、心脏磁共振成像、CT血管造影及三角网格重建，明确诊断左心室心外膜下室壁瘤，经心包穿刺置管引流及保守治疗后好转出院。三角网格重建结合超声心动图可能有助于评估左心室心外膜下室壁瘤破裂风险，为临床实践提...

[Predictive value of the anatomical structure of pulmonary vein antrum for the recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation].

Objective: To investigate the predictive value of pulmonary vein antrum anatomy for recurrence after radiofrequency catheter ablation (RFCA) in patients with paroxysmal atrial fibrillation (PAF). Meth...

[Effects of CPAP therapy on blood pressure and vascular endothelial function in hypertensive patients with moderate-to-severe obstructive sleep apnea].

Objective: To investigate the effect of continuous positive airway pressure (CPAP) therapy on blood pressure and vascular endothelial function in patients with hypertension and moderate-to-severe obst...

Gut Microbiota in Metabolic Syndrome: Differences in Microbial Signatures and Clinical Profiles.

Metabolic syndrome (MetS) is a complex and heterogeneous condition characterized by the coexistence of obesity, type 2 diabetes mellitus (T2DM), hypertension, chronic low-grade inflammation, and metab...

Overview of the Prevalence of Noncommunicable Chronic Diseases in the Brazilian Population Reporting Physical Inactivity.

Exposure to physical inactivity (PI) may be a risk factor for the development of one or more noncommunicable chronic diseases (NCDs). The present study examined the prevalence of diabetes, hypertensio...

Bioinspired porous metal-amino acid nanozymes enable multi-pathway treatment of atherosclerosis through anti-oxidation and pro-efferocytosis.

Atherosclerosis is characterized by chronic inflammation, persistent oxidative stress, intimal lipid accumulation, and impaired efferocytosis within plaques. Here, we develop a copper-based porous nan...

Immunocytochemical staining for lymphatic and blood vessels with frozen sections: using LYVE-1 for lymphatic vessel and von Willebrand factor for blood vessel marker.

Almost all human tissues are supplied with lymphatic vessels, yet histological structure and function of lymphatic vessels is still elusive. Most immunocytochemical studies have been performed with th...

Neonatal Total Parenteral Nutrition and Long-Term Metabolic Outcomes: An 18-Year Nationwide Cohort Study of 2.3 Million Infants.

Background/Objectives: Total parenteral nutrition (TPN) is essential for neonates unable to receive adequate enteral feeding, but its long-term metabolic effects remain uncertain. This study evaluated...

[In search of atrial fibrillation after cryptogenic stroke; suggestions for a broader approach].

In 25-40% of patients with thromboembolic stroke, current diagnostics fail to identify a cause. It has been shown that prolonged heart rhythm monitoring can detect atrial fibrillation (AF) as the unde...

Causal Association Between Idiopathic Pulmonary Fibrosis and Coronary Artery Disease: A Bidirectional Two-Sample Mendelian Randomization.

AIMS/BACKGROUND: Coronary artery disease (CAD) has been epidemiologically linked to idiopathic pulmonary fibrosis (IPF); however, the genetic basis of this association remains unclear. Therefore, this...

Hepatocellular Carcinoma Presenting With Extensive Portal Vein Tumour Thrombus Without Evidence of Underlying Liver Cirrhosis or Steatosis: A Case Report.

AIMS/BACKGROUND: Most cases of hepatocellular carcinoma (HCC) develop in the setting of chronic liver disease (CLD), usually with chronic inflammation, fibrosis, or cirrhosis. The case aims to highlig...

Effect of pictorial-based information about atherosclerosis on adherence to lifestyle recommendations: results from the VIPVIZA randomised controlled trial.

AIM: Low adherence to a healthy lifestyle constitutes a major barrier to effective prevention of cardiovascular disease. We aimed to investigate the effect of pictorial-based information about subclin...

In silico pipeline for GSK 3β inhibitor discovery in Alzheimer's disease using pharmacophore screening, docking, ADME filtering, and MD validation.

Glycogen synthase kinase-3β (GSK-3β) is a key therapeutic target for Alzheimer's disease, but identifying safe, brain-penetrant inhibitors remains difficult. This study aimed to discover novel CNS-act...

Recurrent embolic cerebellar infarction due to bow hunter's syndrome of the non-dominant vertebral artery.

We describe a rare presentation of bow hunter's syndrome (BHS) involving the non-dominant vertebral artery (VA), leading to recurrent embolic cerebellar infarction. A male in his mid-70s presented wit...