Association between liver fibrosis severity and impaired myocardial glucose metabolism in subjects with different degrees of glucose tolerance.

INTRODUCTION: Increasing evidence suggests that liver fibrosis is an independent risk factor for cardiovascular disease. However, the mechanisms underlying this increased risk are still unsettled. The...

Long-Term Associations of a Mobile-Based Chronic Disease Management Program With Employee Health: Four-Year Retrospective Cohort Study.

BACKGROUND: The burden of hypertension (HTN), type 2 diabetes mellitus (DM), and obesity is increasing among employees, driven by workplace-related factors such as sedentary behavior and unhealthy lif...

Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease-linked transcription factor.

Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type-specific gene regulation is linked to the reorganization of three-dimensio...

Single-cell multiomics and chromatin structure reveal gene-regulatory dynamics in heart failure.

Heart failure is a leading cause of morbidity and mortality, yet gene-regulatory mechanisms driving cell type-specific pathologic responses remain undefined. Here, we present the cell type-resolved tr...

Tnxb Alleviates Myocardial Ischemia-Reperfusion Injury Through Facilitating Akt-Dependent Endothelial Cell Survival and Angiogenesis in Mice.

Tenascin-X (Tnxb) is a large extracellular matrix protein that has been associated with atherosclerosis. The objective of this study was to investigate the effect of Tnxb and its contribution to recov...

Spatial risk of hypertension in rural China: modelling the effect of dietary, behavioural and climate factors.

Hypertension poses a major health challenge for the rural elderly in China, but evidence on its spatial patterns and key influencing factors is still limited. This study examined the spatial distribut...

Large-Scale Plasma Proteomics Profiles for Predicting Atrial Fibrillation Associated Stroke Risk : Type of manuscript: Original Research.

BACKGROUND: Stroke is a major complication of atrial fibrillation (AF), and risk prediction using the congestive heart failure, hypertension, age, diabetes, stroke, vascular disease, and sex category ...

Methyltransferase METTL1 Upregulates USF2 in a m7G-Dependent Manner to Accelerate Septic Cardiomyopathy by Inactivating PINK1/Parkin-Mediated Mitophagy.

Septic cardiomyopathy (SCM) is a severe complication of sepsis, characterized by high mortality. The activation of mitophagy in cardiomyocytes is crucial for alleviating SCM. The N7-methylguanosine (m...

Glymphatic Dysfunction and Aquaporin-4 Dysregulation in Traumatic Brain Injury and Brain Tumors: A Review.

The glymphatic system is a cerebrospinal fluid-interstitial fluid exchange pathway that clears metabolic waste and maintains brain fluid homeostasis. Aquaporin-4 (AQP4), a water channel at astrocytic ...

The Role of Echocardiography in the Assessment of Epicardial Adipose Tissue: A Systematic Review and Meta-analysis.

BACKGROUND: Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot implicated in cardiometabolic and cardiovascular (CV) disease. Although cardiac magnetic resonance (CMR) and ca...

The New Spine of Access to the Brain's Secrets: Extracellular Vesicles from Cerebrospinal Fluid Liquid Biopsies in CNS Diseases and Blood-Brain Barrier Research.

Liquid biopsy is emerging as a powerful approach for less invasive biomarker discovery, with extracellular vesicles (EVs) in cerebrospinal fluid (CSF) showing promise for the assessment of central ner...

Micro- and Nanoplastics in Cardiovascular Toxicology: Human Tissue Detection, Clinical Phenotypes, and Adverse Outcome Signals.

Micro- and nanoplastics (MNPs) have emerged from a diffuse environmental concern to a plausible cardiovascular exposure with potential clinical relevance. The current evidence base is heterogeneous: h...

SIRT5 Attenuates Doxorubicin-Induced Acute Cardiac Injury by Modulating PHB2 Succinylation and the Mitophagic Response.

Doxorubicin (DOX)-induced cardiac injury remains a major limitation of chemotherapy and is closely linked to mitochondrial dysfunction, oxidative stress, and dysregulated mitophagy. Sirtuin 5 (SIRT5),...

Large-scale synthetic data enable digital twins of human excitable cells.

Individual variability shapes how diseases manifest, how patients respond to therapy and how rare phenotypes arise. Conventional experimental approaches obscure variation by averaging which limits mec...

A Novel Presentation of Hemodynamic Decompensation With Cardiogenic Shock in a Patient With Partial Anomalous Pulmonary Venous Return.

BACKGROUND Partial anomalous pulmonary venous return (PAPVR) is a rare congenital cardiovascular anomaly that can remain clinically silent until significant shunting results in pulmonary hypertension ...

Blood-brain barrier water permeability is elevated in type 2 diabetes and obesity: associations with cognitive function and metabolic markers.

BACKGROUND: Type 2 diabetes (T2D) and obesity are established risk factors for Alzheimer's disease and related dementias, yet the cerebrovascular mechanisms linking metabolic dysfunction to cognitive ...

In vitro multi-organ invasion model for exploring cardiac resistance to cancer metastasis.

Despite the systemic spread of cancer, the ventricular myocardium is one of the least common sites of metastasis-a phenomenon that remains poorly understood. To examine this, we develop the Multi-orga...

Comparison of rotational atherectomy and modified balloons for calcified lesion preparation: a single-centre experience.

AIM: To compare the efficacy and safety of rotational atherectomy (RA) and modified balloons (MB) for calcified coronary lesion preparation. METHODS: This retrospective, single-centre study included 9...

Ubiquitin-Related Proteostatic Programs in Cycling Fibroblast-Lineage Remodeling After Myocardial Ischemic Injury: A Hypothesis Informed by Single-Cell and Spatial Transcriptomics.

Myocardial ischemia and reperfusion initiate spatially organized injury-repair programs that subsequently shape ventricular remodeling. Although cardiac fibroblasts are indispensable for scar formatio...

Candidate Biomarkers Linking Periodontitis with Atherosclerotic and Related Cardiovascular Phenotypes: A Systematic Review Focused on Sex-Specific Evidence.

Periodontitis and cardiovascular disease share inflammatory, immune, endothelial, oxidative, and lipid-related pathways. Although sex-related differences are well established for many cardiovascular b...