Cost-effectiveness of genome-guided statin treatment for hypercholesterolemia.

Cardiovascular disease and hypercholesterolemia present significant global health and economic burdens. While statins are the standard treatment, individual variability and toxicities necessitate pers...

Association between SGLT2 inhibitors and outcomes after heart transplant in patients with type 2 diabetes: A systematic review and meta-analysis.

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are recommended for multiple populations-type 2 diabetes (T2D), chronic kidney disease, and heart failure-but their role after heart transplant (HTX)...

Investigation of catheter navigation through flexible intracranial vessel: a combined in silico and in vitro study.

Trackability of thrombectomy catheters through tortuous cerebral vessels is a key determinant of mechanical thrombectomy success, particularly for large-bore aspiration catheters. Yet, the underlying ...

Association of intensive blood pressure lowering with health-related quality of life after endovascular thrombectomy: a post-hoc analysis of the ENCHANTED2/MT trial.

BACKGROUND AND PURPOSE: Intensive blood pressure (BP) targets of less than 120 mm Hg have been shown to worsen functional outcomes after endovascular thrombectomy (EVT) for acute ischemic stroke. Howe...

Tubular epithelial cells promote macrophage pyroptosis through PANX1-extracellular ATP-P2X7 signaling in aldosterone-dependent renal injury.

Tubular epithelial cell (TEC)-macrophage crosstalk contributes to aldosterone (Aldo)-dependent renal fibrosis in hypertension. Extracellular ATP (eATP) can act as a mediator of TEC-macrophage crosstal...

Convergent blood-brain barrier breakdown in schizophrenia and autism spectrum disorders: a systematic review of preclinical animal models.

BACKGROUND: Schizophrenia (SCZ) and autism spectrum disorder (ASD) are neurodevelopmental disorders with multifactorial origins involving genetic and environmental risk factors. Both conditions share ...

Suppression of Ephx2 in endothelial cells of penile cavernouse tissue improves SHR erectile function.

INTRODUCTION: Hypertension is a major cause of erectile dysfunction (ED). The impact of hypertension on the transcriptome and proteome of penile corpus cavernosum tissue, as well as its relationship w...

Blood-Ocular Barrier Dysfunction in Uveitis: A Bidirectional Model Linking Pathogenesis, Clinical Monitoring, and Therapeutic Opportunities.

Uveitis is a heterogeneous group of intraocular inflammatory diseases and an important cause of visual impairment worldwide. Although current treatments mainly target inflammation, many patients devel...

The early-term effects of the minimally invasive extracorporeal circulation on atrial fibrillation development in patients who underwent coronary artery bypass grafting.

OBJECTIVE: The minimised extracorporeal circulation (MiECC) system is an alternative to the classical extracorporeal circulation (ECC) system in coronary artery bypass grafting (CABG) surgery. Some pu...

Thyroid Artery Flow Velocity and Serum Adenosine Deaminase After Methimazole Therapy in Autoimmune Hyperthyroidism.

Autoimmune hyperthyroidism, including Graves' disease and Hashimoto's hyperthyroidism, presents with overlapping biochemical features but distinct pathophysiological mechanisms. Non-invasive methods t...

Aconitine Induces Myocardial Damage in Rats Associated With Activation of the JNK1/2 Signaling Pathway.

Acute Aconitine (Acon) poisoning can cause arrhythmia and myocardial damage; however, the underlying mechanisms remain unclear. This study investigated the mechanism of myocardial injury induced by ac...

Validity testing of the novel European Society of Cardiology EURObservational Research Programme PPCM Registry score to predict left ventricular recovery in a cohort of Ugandan women with PPCM.

BACKGROUND: Recently under the European Society of Cardiology (ESC) EURObservational Research Programme (EORP) PPCM registry the first predictive score was derived. This study sought to test the valid...

Mid-term results of bicuspid aortic valve repair with a new technique, the Ozbek procedure.

INTRODUCTION: Aortic valve insufficiency has been reported in approximately one-third of patients with a bicuspid aortic valve (BAV). In this study, we describe a new use of an old aortic repair techn...

Case report: unilateral varicose veins.

A healthy 69-year-old man presented to the cardiovascular surgery outpatient department with a 20-year history of right leg swelling and varicose veins (Figure A). He denied experiencing resting pain ...

Safety and efficacy of lorundrostat, an aldosterone synthase inhibitor, in patients with uncontrolled hypertension: A systematic review and meta-analysis.

BACKGROUND: Limited data from randomized controlled trials (RCTs) indicate that lorundrostat, an aldosterone synthase inhibitor, may be effective in managing uncontrolled hypertension (HTN). Currently...

Ginsenoside Rh2 Regulates PI3K/AKT Signaling, Metabolic Pathways, and the Gut Microbiota for Coronary Heart Disease Therapy.

This study investigated the molecular mechanisms underlying the therapeutic effects of ginsenoside Rh2 (G-Rh2) in coronary heart disease (CHD) through a network pharmacology approach, focusing on iden...

Identifying a Safety Threshold for Parenteral Glucose Intake in the Early Acute Phase of Preterm Neonates.

Background/Objectives: The safety of specific parenteral glucose intake values within the range currently recommended by international guidelines for the early acute phase in preterm neonates has not ...

Aortic root abscess in a high-risk case requiring modified hemi-UFO procedure with custom-made pericardial conduit - a case report.

BACKGROUND: The UFO procedure is an established surgical technique to treat extensive endocarditis of the aortic or mitral valve with involvement of the intervalvular fibrous body (IVFB). This techniq...

Association of antihypertensive drugs, intestinal ischemia, and breast diseases: A drug-target Mendelian Randomization study.

Both hypertensive and breast diseases impose a significant societal burden. However, the correlation between antihypertensive drug use and breast cancer remains controversial. We aimed to determine th...

Coronary Artery Calcification: From Molecular Mechanisms to Interventional Strategies.

Coronary artery calcification (CAC) represents a clear sign of advanced atherosclerosis and a strong indicator of coronary artery disease burden and cardiovascular risk. Beyond its established prognos...