Complementary cardiac functional assessment using systolic time intervals and bioelectrical impedance analysis.
BACKGROUND: The Forrester classification remains a cornerstone for assessing haemodynamic status in heart failure, yet its clinical application is restricted by the invasiveness of right heart cathete...
Matrix Metalloproteinase-9-Responsive Lipid-Core Micelles for Proof-of-Concept Enzyme-Triggered Cardiomyocyte Association.
Cardiovascular diseases (CVDs) remain the leading cause of global mortality and are frequently associated with increased matrix metalloproteinase-9 (MMP-9) activity during cardiac remodeling and infla...
Algorithm-based quantification of tissue vascularization in immunohistochemical stainings of tissue sections.
The vascular system ensures sufficient blood supply and tissue homeostasis and consists of different cell types. Endothelial cells represent the structural backbone of blood vessels and are accompanie...
Engineering an AIEgen-based platform integrating CRISPR/Cas9 to remodel the tumor microenvironment and reinforce photo-immunotherapy against glioblastom.
Glioblastoma remains one of the most lethal brain tumors. Although immunotherapy and other therapeutic modalities has achieved significant therapeutic success in several malignancies, its efficacy in ...
Hypokalaemic paralysis as a presenting feature of primary aldosteronism.
A woman in her 30s presented with acute flaccid paraparesis secondary to severe hypokalaemia. She had a known history of hypertension controlled on amlodipine and bisoprolol. Biochemical workup reveal...
Cardiac imaging in Chagas cardiomyopathy for phenotypic characterisation and risk stratification.
Chagas disease, caused by Trypanosoma cruzi, remains one of the leading infectious causes of non-ischemic cardiomyopathy worldwide. Although an estimated 6-7 million individuals are chronically infect...
Cardiac microcurrent therapy in heart failure: Mechanistic rationale, early clinical evidence, and future directions.
Despite major advances in guideline-directed medical therapy (GDMT), many patients with heart failure with reduced ejection fraction (HFrEF) remain symptomatic, with persistent limitations in function...
Impaired Glymphatic Function and Post-stroke Cognitive Decline after Intracerebral Hemorrhage: A Serial Neuroimaging Study.
After an intracerebral hemorrhage (ICH), impaired glymphatic function (GF) can result in neurotoxin buildup in the brain. In this serial MRI imaging study, we investigated the association between impa...
Stent placement as rescue treatment in acute basilar artery occlusion.
INTRODUCTION: We investigated the etiology, safety and efficacy of endovascular treatment with and without stent placement as rescue treatment in patients with acute ischemic stroke due to basilar art...
HMGB1 promotes intracranial aneurysm progression by regulating vascular smooth muscle cell phenotypic switching and ferroptosis.
Phenotypic switching in vascular smooth muscle cells (VSMCs) is key to the formation and progression of intracranial aneurysms (IAs). High-mobility group box 1 (HMGB1), a damage-associated molecule, s...
Optimising patient selection for adrenal vein sampling in primary aldosteronism: role of biochemical markers and scoring systems.
BACKGROUND: Adrenal vein sampling (AVS) is the gold standard for subtyping primary aldosteronism (PA), but the role of adrenocorticotropic hormone (ACTH) stimulation during this procedure remains deba...
Large Animal Models of Tricuspid Regurgitation: Relevance, Limitations, and Future Directions.
Despite growing interest in tricuspid regurgitation (TR), evidence remains insufficient to define the optimal timing of intervention and therapeutic strategies, highlighting the need for robust experi...
The enigmatic occipital emissary vein, foramina, and canals: anatomical study with application to skull base surgery.
Compared with mastoid emissary veins, occipital emissary veins have been less studied, and published descriptions of their foramina are inconsistent. This anatomical investigation aimed to clarify the...
A Age Related Vascular Senescence: Mystery of Blood-brain Barrier Dysfunction in Neurodegeneration.
The pathophysiology of neurodegenerative illnesses is increasingly understood to be influenced by vascular aging, with blood-brain barrier (BBB) disruption emerging as a crucial mechanistic connection...
[A double-island flap based on the lateral circumflex femoral artery for soft tissue reconstruction after radical resection of advanced oral and oropharyngeal cancer].
Objective: To report the surgical strategy for harvesting a double-island flap based on the lateral circumflex femoral artery (LCFA) for reconstruction of complex soft tissue defects following radical...
Hemorrhagic Myocardial Infarction and Intramyocardial Hemorrhage: From Microvascular Damage to Emerging Therapeutic Targets.
Intramyocardial hemorrhage (IMH) is a severe form of post-ischemic microvascular injury that may occur after myocardial infarction, particularly in the setting of extensive ischemia and reperfusion. I...
Percutaneous Transcatheter Embolization for Recurrent Cerebral Embolism Due to Pulmonary Arteriovenous Malformation.
BACKGROUND Pulmonary arteriovenous malformations (PAVMs) are rare structural vascular abnormalities that create communications between pulmonary arteries and veins, resulting in right-to-left shunts. ...
Nocturnal Hypoxic Exposure Combined with Two-Week Hypoxic Training and Calorie Restriction Improves Lipid Profile and Body Composition in Men with Obesity-Related Hypercholesterolemia: A Controlled Intervention Study.
Despite advances in lifestyle-based therapy, achieving clinically meaningful reductions in blood lipid levels remains a major challenge in obese men with secondary hypercholesterolemia. Hypoxic exposu...
Differential Associations of Oxidative Biomarkers with Symptomatic and Systolic Severity in Heart Failure.
Background and Objectives: Oxidative stress is recognized as an important contributor to heart failure (HF) pathophysiology, but the relationships of individual oxidative and antioxidant biomarkers wi...
PAP Versus DIEP Flap Breast Reconstruction: Current Evidence and the Unresolved Question of Timing and Oncologic Safety-A Narrative Review.
Background/Objectives: Deep inferior epigastric perforator (DIEP) flap reconstruction represents the gold standard for autologous breast reconstruction, while profunda artery perforator (PAP) flap rec...