An analysis of digoxin serum concentrations and influencing factors: A cross-sectional study from a tertiary hospital in China.

The digoxin drug has a narrow therapeutic window that requires regular blood concentration monitoring in a tertiary hospital. The concentration of a drug varies due to several factors. The factors may...

Risk factors and self-management predictors of activities of daily living in patients with heart failure: A 12-month prospective cohort study.

Impaired activities of daily living (ADL) significantly affect the prognosis and quality of life in patients with heart failure (HF). We aimed to identify the key clinical and self-management predicto...

Usefulness of serum creatinine-to-albumin ratio for 28-day all-cause mortality in critically ill patients with atrial fibrillation: A retrospective study based on the MIMIC-IV database.

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and is associated with increased short-term mortality in critically ill patients. The creatinine-to-albumin ratio (CAR) is associ...

Relationship between C-reactive protein-to-albumin ratio and new-onset coronary artery disease and its severity in different glucose metabolic states: A retrospective cohort study.

The C-reactive protein-to-albumin ratio (CAR) integrates inflammatory and nutritional status.The study aimed to explore the potential connection between CAR and new-onset coronary artery disease (CAD)...

Differential associations of distinct anthropometric indices with heart failure in adults with MASLD: A cross-sectional study of NHANES 2017 to 2020.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to cardiovascular morbidity, yet it remains unclear which anthropometric indices most effectively capture the burden ...

Seven-year experience (2018-2025) of a hospital-based cardiovascular tissue bank in Israel: operational insights and clinical impact.

Cryopreserved human heart valves and cardiovascular tissues (homografts) are essential for the surgical treatment of congenital and acquired valvular diseases, particularly in pediatric patients, wher...

Beyond Clozapine: Myocarditis and Cardiomyopathy Associated with Antipsychotic Medications-An Updated Narrative Review for Psychiatric Practice.

BACKGROUND: Antipsychotic medications are associated with increased cardiovascular morbidity and mortality in patients with serious mental illness (SMI). Clozapine-induced myocarditis and cardiomyopat...

Micro-and Nano-Plastic Exposure as an Emerging Risk for Atherosclerotic Cardiovascular Disease.

PURPOSE OF REVIEW: This review examines micro- and nanoplastic (MNP) exposure as an emerging risk factor for atherosclerotic cardiovascular disease, focusing on how individual-level exposures shaped b...

Century of Progress on the Structure of APOB-100 in Atherogenic Lipoproteins.

APOB-100 (apolipoprotein B100) is the obligate structural protein of very low-density lipoprotein (VLDL), intermediate density lipoprotein, and low-density lipoprotein (LDL), with each atherogenic par...

Antibody E06 and the Role of Oxidized Phospholipids in Atherogenesis and Inflammation.

Oxidized phospholipids (OxPL) are generated at sites of oxidative stress and tissue injury, where they function as prototypic danger-associated molecular patterns that trigger inflammation, cell death...

Septic cardiomyopathy: a rare and life-threatening complication of small intestinal perforation: A case report.

RATIONALE: Septic cardiomyopathy (SCM) is a severe and often reversible complication of sepsis but carries a high mortality rate when it progresses to cardiogenic shock. Differentiating SCM from acute...

A cross-sectional study on the prevalence of cardiometabolic diseases and their multilevel socioeconomic impacts in Qianxinan Buyi and Miao Autonomous Prefecture, Southwest China.

Cardiometabolic diseases (CMDs) have become the leading cause of mortality and disease burden in low- and middle-income regions, including ethnic minority areas in southwest China. However, population...

Association between coronary artery disease and viral hepatitis: Perspectives based on the 2017-2018 National Health and Nutrition Examination Survey and Mendelian randomization analyses.

Coronary artery disease (CAD) is one of the leading forms of cardiovascular disease in Europe and the primary cause of death in the region, while millions of individuals in Europe remain chronically i...

Echocardiographic evaluation of right ventricular function before and after percutaneous coronary intervention in patients with coronary artery disease and pulmonary hypertension: A single-center retrospective cohort study.

Right ventricular (RV) dysfunction in patients with coronary artery disease (CAD) and concomitant pulmonary hypertension (PH) is associated with poor outcomes, yet its short-term reversibility after p...

The bidirectional mechanistic links between Alzheimer's disease and cardiovascular disease.

BACKGROUND: Alzheimer's disease (AD) and cardiovascular disease (CVD) are two significant chronic diseases that have a profound impact on the health of the elderly globally. In recent years, an increa...

Kidney-Vascular Metabolic Crosstalk: Altered Lipoproteins in CKD.

Cardiovascular disease and chronic kidney disease are highly interconnected, with declining kidney function markedly increasing cardiovascular risk. Chronic kidney disease profoundly disrupts lipoprot...

New and Emerging Therapeutic Targets for ApoB-Containing Particles Lowering.

ApoB is the structural protein of all atherogenic lipoproteins, including VLDLs (very-low-density lipoproteins), IDLs (intermediate-density lipoproteins), LDLs (low-density lipoproteins), chylomicron ...

Cardiac Lipid Metabolism: Cells, Metabolites, and Rhythms.

Although studied for decades, metabolic therapies that target cardiac lipid metabolism are underdeveloped, and most approaches have thus far failed as a heart failure treatment. In contrast, new thera...

Noninvasive optogenetic induction of cardiac arrhythmias alters systemic hemodynamics in mice.

Mouse models are valuable for studying the systemic effects of arrhythmia, but traditional methods of heart pacing are invasive and technically complex. Cardiac optogenetics enables precise control of...

Translating Lipoprotein Genetics Into New Therapies.

Human genetics has become the primary engine for identifying lipid-lowering drug targets and predicting therapeutic success or failure. Monogenic family studies and population-based sequencing identif...