Integrative analysis of bulk and single-nucleus transcriptomes suggests proteostasis- and metabolism-related alterations in the right ventricular outflow tract of non-syndromic Tetralogy of Fallot.

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease, among which non-syndromic TOF (nsTOF) represents the most common subtype; however, the molecular mechanisms underlying r...

PSAP Protects Against Acute Myocardial Ischemia-Reperfusion Injury by Promoting ASAH1-Mediated Ceramide Metabolism.

Myocardial ischemia-reperfusion (I/R) injury remains a leading cause of cardiovascular morbidity. However, due to the unclear underlying molecular mechanisms, effective therapeutic approaches are stil...

Terminal branching pattern of posterior tibial artery in the tarsal tunnel: a cadaveric study with its clinical importance in medial ankle surgeries.

PURPOSE: The posterior tibial artery (PTA) branching within the tarsal tunnel is subject to significant anatomical variation, which can complicate surgical procedures such as tarsal tunnel decompressi...

Emergency access to the subclavian vessels by non-thoracic surgeons: a cadaver-based learning model for orthopedic trauma surgery.

PURPOSE: The aim of this study was to evaluate the procedural time and safety of an infraclavicular approach to the subclavian vessels for damage control of major upper extremity vascular injuries. Th...

Myocarditis in idiopathic inflammatory myopathies: serologic and clinical correlates in a single-center registry.

To characterize the clinical and serological correlates of cardiovascular magnetic resonance (CMR)-confirmed myocarditis in idiopathic inflammatory myopathies (IIM), evaluate the diagnostic performanc...

Modification of a poroelastic model for zero porosity: finite element implementation and investigation of fluid mechanics in the perivascular space.

In conventional formulations of poroelasticity, when the porosity approaches zero or vanishes in some parts of the poroelastic domain, if only temporarily, the governing equations degenerate to those ...

Transjugular Transcatheter Tricuspid Valve Implantation of Coronary Stent System for Creating a Rat Tricuspid Regurgitation Model.

We aimed to establish a rat TR model to further investigate the mechanisms of right heart remodeling and organ damage induced by TR. Intervention group rats (n = 6) underwent coronary stent system imp...

Atrial cardiomyopathy as a multidomain disease: longitudinal evidence for autonomic remodelling.

AIMS: Atrial cardiomyopathy (AtCM) is increasingly recognized as a substrate for atrial fibrillation (AF), yet its operationalization remains limited and largely marker-driven. Whether autonomic remod...

Compliance to direct oral anticoagulation therapy and clinical outcomes after catheter ablation for atrial fibrillation: a nationwide cohort study.

BACKGROUND AND AIMS: Life-long direct oral anticoagulant (DOAC) therapy is recommended after catheter ablation for atrial fibrillation (AF) in high-risk patients (CHA2DS2-VA≥2). Long-term DOAC complia...

Catheter ablation of atrial fibrillation in transthyretin and light-chain cardiac amyloidosis: results from the multicentre AMYL-AF study.

AIMS: Atrial fibrillation (AF) is highly prevalent among cardiac amyloidosis (CA) patients and contributes significantly to their morbidity and mortality. Evidence regarding AF ablation efficacy and s...

Artificial Intelligence-Derived Electrocardiogram Analysis for Identification of Carbon Monoxide-Induced Cardiomyopathy: A Retrospective Study.

Background and Objectives: The diagnostic accuracy of an artificial intelligence (AI)-derived initial 12-lead electrocardiogram (ECG) analysis was evaluated for early carbon monoxide-induced cardiomyo...

The Association Between Abnormal Electrocardiogram Findings and the Ankle Brachial Index.

Background and Objectives: Peripheral artery disease (PAD) is a common manifestation of systemic atherosclerosis associated with significant morbidity and mortality, yet it remains underdiagnosed due ...

The Complex Role of Methylation in Regulating Vascular Smooth Muscle Cell Phenotypic States in Vascular Remodeling and Atherosclerosis.

Vascular smooth muscle cell (VSMC) control of phenotypic states through regulation of contractile gene expression is critical for vascular homeostasis and for participation in pathological vascular re...

Early catheter ablation vs. antiarrhythmic drugs in treatment-naïve ischaemic ventricular tachyarrhythmias: a meta-analysis of randomized controlled trials.

INTRODUCTION: Antiarrhythmic drugs (AADs) have traditionally been used as first-line therapy for ventricular tachycardia (VT) but are frequently associated with systemic toxicities and drug interactio...

Olive Oil-Based Lipid Emulsion Ameliorates Immune Checkpoint Inhibitor-Induced Myocarditis via Inhibition of the NF-κB/NLRP3/IL-1β Pathway.

The present study aimed to investigate the therapeutic efficacy and underlying mechanism of olive oil-based lipid emulsions (OOLE) in mitigating immune checkpoint inhibitor (ICI)-induced myocarditis t...

In Utero Fetal Lamb Model of Mitral Inflow Obstruction To Induce Hypoplastic Left Heart Syndrome-like Physiology.

Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect characterized by underdevelopment of the left ventricle (LV), mitral valve, aortic valve, and ascending aorta. Based on the "...

The peptide ACTY116 improved noradrenaline-induced cardiac hypertrophy and enhanced cardiac function by biasing receptor signaling toward the β-arrestin and against the Gαq protein.

OBJECTIVES: Myocardial hypertrophy, is a major precursor to heart failure, is characterized by a lack of targeted therapeutic efficacy. ACTY116, investigated by our group, is a novel peptide designed ...

Anti-Inflammatory Interleukins in the Pathogenesis of Atherosclerosis.

In recent years, the study of interleukins (ILs), crucial cytokines involved in inflammation, has garnered significant attention within coronary artery disease including atherosclerosis. This review p...

CLARISA: Connexin-43 Lateralization Automated ROI-Based Image Signal Analyzer.

Connexin-43 (CX43) lateralization in ventricular myocardium has been associated with abnormal impulse propagation and increased arrhythmia susceptibility. Its quantitative assessment in histological s...

Regional tissue oxygen saturation as an indicator of wound healing during endovascular treatment for chronic limb-threatening ischaemia.

OBJECTIVE: It is important to evaluate limb blood flow during the perioperative period to salvage affected limbs in patients with chronic limb-threatening ischaemia (CLTI). However, it is difficult to...