Bridging veins govern discrepancy of CSF efflux into dura mater in mice.

Meningeal lymphatic vessels within the dura provide a route for cerebrospinal fluid (CSF) outflow, but how CSF crosses the arachnoid barrier, particularly toward basal dural compartments, remains uncl...

Sequential changes in calcium transients during M phase regulate cardiomyocyte proliferation.

Heart muscle growth and regeneration require the proliferation of cardiomyocytes. Rapid pulsatile increases in cytosolic Ca2+ concentration, called calcium transients (CaTs), trigger cardiomyocyte con...

Cardiovascular disease is the leading cause of death in women, yet significant disparities persist in diagnosis, treatment, and research representation. This clinical consensus statement outlines the ...

Adults with repaired tetralogy of Fallot (TOF) face long-term risks of ventricular tachycardia (VT) and sudden cardiac death (SCD). There is no consensus on arrhythmia management during surgical pulmo...

The life expectancy of adult patients with congenital heart disease (ACHD) has improved, thus shifting the research focus towards age-related comorbidities to continue to improve patient outcomes. Thi...

Upregulated Renal Mineralocorticoid Receptor and 11β-Hydroxysteroid Dehydrogenase Type 2 Are Associated with K(+) Retention During MR Antagonism in Female Spontaneously Hypertensive Rats.

Mineralocorticoid receptor (MR) blockade exerts sex-specific effects in hypertension and cardiovascular disease; however, its role in blood pressure regulation in spontaneously hypertensive rats (SHRs...

ATP6AP2 ameliorates inflammation and pyroptosis in heart failure by promoting lysosome-dependent STING degradation.

Inflammatory activation is involved in the pathogenesis of heart failure (HF). ATPase H+-Transporting Accessory Protein 2 (ATP6AP2) is an auxiliary subunit of the V-ATPase, and its role in HF is not f...

[Construction of a risk prediction model for vascular function damage in children with primary hypertension].

Objective: To investigate the risk factors of vascular function damage in children with primary hypertension and establish a risk prediction model. Methods: In this retrospective case-control study, a...

[Advances in diagnosis and treatment for heart failure with preserved ejection fraction in children].

儿童射血分数保留的心力衰竭（HFpEF）病因谱复杂、表型高度异质，常与先天性心脏病、心肌病、遗传性综合征、肺动脉高压及肥胖代谢异常等因素相关，诊断和治疗均不能简单套用成人经验。近年来，年龄分层的心功能评估、心脏磁共振成像、新型生物标志物及机制导向治疗为儿童HFpEF的识别和干预提供了新思路。现围绕儿童HFpEF的诊断评估、分子病理机制及机制导向治疗进展进行综述，以期为分层诊疗和未来研究提供参考。.

[Age-stratified analysis of left ventricular ejection fraction threshold heterogeneity for heart failure with preserved ejection fraction in children].

Objective: To explore age-adapted left ventricular ejection fraction (LVEF) diagnostic thresholds for heart failure with preserved ejection fraction (HFpEF) in children. Methods: In this multicenter r...

Comparison of Oral and Intravenous Nitroglycerin in the Treatment of Acute Postpartum Hypertension After Cesarean Delivery for Preeclampsia.

BACKGROUND: Acute postpartum hypertension is common among women with preeclampsia, particularly after cesarean delivery, and is traditionally managed with intravenous (IV) antihypertensive agents. How...

Gender-based Assessment of Cardiovascular Risk Factors among Young Hypertensives in a Tertiary Hospital in Southwestern Nigeria: A Cross-sectional Study.

BACKGROUND: Gender variation exists in the clustering of cardiovascular (CV) risk factors. Hypertension (HTN), diabetes mellitus (DM), lipid abnormalities, obesity, cigarette smoking, and significant ...

Development of a histological grading system for assessing microplastic-induced structural damage in rat aorta, trachea, and bladder tissues following acute exposure.

INTRODUCTION: Microplastic (MP) exposure has increasingly been associated with tissue-level impact in toxicology studies, including inflammatory changes and histopathological injury in aquatic and mam...

Modeling chronic kidney disease progression using a continuous-time multistate Markov model: Transition dynamics and covariate effects.

Chronic kidney disease is a progressive condition that impairs renal function and can ultimately lead to kidney failure. Its progression involves multiple intermediate stages, making conventional surv...

Medicare Accountable Care Organizations: Clinical Performance for Patients With Heart Failure.

OBJECTIVES: Objective: To understand factors that distinguish higher-performing accountable care organizations (ACOs) in the Medicare Shared Savings Program from those with average levels of clinical ...

Multivariate adaptive regression spline modeling for estimating carotid artery plaque thickness in Chinese men with type 2 diabetes.

ObjectiveThe incidence of type 2 diabetes continues to increase worldwide, with cardiovascular disease as the leading cause of mortality in this population. Carotid artery plaque thickness serves as a...

Trends and Disparities in High-Risk Nonsteroidal Anti-Inflammatory Drug Utilization.

OBJECTIVES: Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) poses a risk to patients with chronic kidney disease (CKD), heart failure (HF), and hypertension (HTN). We evaluated changes in...

Identification of Hub Gene Characteristics and Immune Landscapes Across Aging Subtypes in Atherosclerosis: A Machine Learning-Based Multi-Omics Study With Experimental Verification.

Aging is a major risk factor for atherosclerosis (AS), but the aging-associated molecular characteristics and immune heterogeneity of AS remain incompletely understood. This study aimed to identify ag...

First-Pass Perfusion and T1-weighted Dixon Imaging as Emerging Biomarkers of Pericardial Disease.

Pericardial assessment with cardiac MRI relies on three complementary pillars: anatomic evaluation, functional characterization, and tissue characterization. Tissue characterization traditionally depe...

Blood Pressure and Systemic Risk Factors in Patients Presenting With Post-Extraction and Periodontal Bleeding at a Dental Out-of-Hours Clinic.

OBJECTIVE: This study aimed to verify whether blood pressure was higher in patients presenting to the dental out-of-hours clinic with post-extraction bleeding (PEB) and periodontal disease-related gin...