Double-Stranded DNA Sensing cGAS-STING Immune Signaling in a Rat Co-Culture Model of the Blood-Brain Barrier.
Double-stranded DNA coming from, for example, viruses, bacteria, or apoptotic cells is recognized by the cGAS-STING signaling pathway comprising the cyclic GMP-AMP synthase (cGAS) and the stimulator o...
Acute Management of Dysrhythmias.
Vascular Interventional Radiologists (VIRs) frequently care for patients with high severity of illness, multiple comorbidities, and physiologic derangements. The incidence and prevalence of abnormal c...
Assessment of Right Atrial Function in Patients With Chronic Thromboembolic Pulmonary Hypertension.
BACKGROUND: Chronic thromboembolic pulmonary hypertension (CTEPH) leads to right atrial (RA) dysfunction, which correlates with poor prognosis. However, most studies on RA function in pulmonary hypert...
Management of Large Artery Atherosclerosis.
OBJECTIVE: Large artery atherosclerosis is a common cause of ischemic stroke and transient ischemic attack and presents a high-risk condition for recurrent strokes. This article provides clinicians wi...
Noninvasive Left Ventricular Pressure-Strain Loop for Evaluating Changes in Left Ventricular Function in Colorectal Cancer Patients After Chemotherapy.
OBJECTIVE: To noninvasively monitor cardiac functional changes throughout chemotherapy in colorectal cancer patients using pressure-strain analysis, validate their predictive value for early detection...
Inflammation-Associated Microvascular Dysfunction in Polymyalgia Rheumatica: Reversible Capillary Impairment Documented in an Older Patient.
Longitudinal nailfold videocapillaroscopy in an older patient with polymyalgia rheumatica shows reduced capillary density during active disease and restoration after glucocorticoid therapy, supporting...
Ambulatory Stage C2D Heart Failure Definitions and Current Therapeutic Approaches: JACC: Heart Failure Position Statement.
Symptomatic heart failure (HF) with reduced ejection fraction is traditionally drawn as 2 stages. Most stage C patients report manageable symptoms on guideline-directed medical therapy (GDMT), whereas...
Association of Mitral Annular Disjunction on Magnetic Resonance Imaging With Cardiovascular Outcomes.
BACKGROUND: Mitral annular disjunction (MAD) is increasingly recognised on cardiac magnetic resonance (CMR) imaging, yet its clinical significance remains under discussion. We aimed to determine the p...
Regional Variation of Aetiologies and Complications in Chronic Kidney Disease From Thailand (THAI-CKD Registry).
AIM: To investigate regional variations in Chronic Kidney Disease (CKD) aetiologies and complications across KDIGO risk strata in Thailand, aiming to optimise screening and monitoring in resource-cons...
Hypertension and altitude in community-dwelling older adults: an epidemiological study in northwest China.
OBJECTIVES: Hypertension is a major risk factor for cardiovascular and cerebrovascular diseases, and a relationship between altitude and hypertension has been demonstrated. To better characterise this...
Massive upper gastrointestinal haemorrhage from splenic artery erosion secondary to gastro-gastric fistula following single-anastomosis gastric bypass.
A woman in her 40s presented with massive upper gastrointestinal bleeding a few months after undergoing a single-anastomosis gastric bypass. CT abdomen and pelvis showed a marginal ulcer with adjacent...
AI-based Histologic Heterogeneity of Microvascular Obstruction at Cardiac MRI for Predicting MACEs: A Multicenter Study.
Background Microvascular obstruction (MVO) is strongly associated with adverse outcomes after ST-segment elevation myocardial infarction (STEMI). However, manual quantification of MVO is time-consumin...
Cerebral air embolism from oesophageal-pulmonary vein fistula induced by fish bone ingestion.
Fish bone ingestion is common, but cerebral air embolism as a secondary complication is exceedingly rare. A man in his 80s presented to our tertiary emergency centre after sudden collapse following oe...
Leveraging the Electronic Health Record to Identify and Manage Resistant Hypertension.
PURPOSE OF REVIEW: Resistant hypertension (RH) affects more than a tenth of adults and yet remains relatively underrecognized and undertreated. The electronic health record (EHR) now stands as a criti...
Thyroid storm triggered by immune checkpoint inhibitor therapy.
While immune checkpoint inhibitors (ICIs) have revolutionised cancer treatment, they can cause immune-related adverse events, including thyroid dysfunction and rarely, thyroid storm. Here, we present ...
Increased risk of atrial fibrillation and flutter in patients with Cushing's syndrome: a population-based matched cohort study.
BACKGROUND: Patients with Cushing's syndrome (CS) have a high prevalence of cardiovascular disease, and other recognized risk factors for atrial fibrillation/flutter (AF/AFL); however, the prevalence ...
Fixed-Dose Combinations for Hypertension: Barriers to Use and Opportunities for Health Systems.
BACKGROUND: Uncontrolled hypertension is a leading driver of heart disease, chronic kidney disease, heart failure, dementia, stroke, and pregnancy-related complications. Fixed-dose combinations (FDCs)...
Opportunistic Assessment of Coronary Artery Calcium Volume and Density From Non-Electrocardiogram-Gated Chest CT Using Artificial Intelligence: Prognostic Implications in a Screening Cohort.
OBJECTIVE: The prognostic value of coronary artery calcium (CAC) volume and density was derived from an automated artificial intelligence (AI)-based analysis of non-electrocardiogram-gated chest CT. M...
Plasma proteomics enhances heart failure risk prediction among individuals with type 2 diabetes: a prospective cohort study.
BACKGROUND: Heart failure (HF) is a severe complication of type 2 diabetes (T2D), yet the association between plasma proteins and HF in individuals with T2D remains underexplored. OBJECTIVES: This stu...
Automated Centerline Extraction From Meshed Vascular Models.
Centerlines of vascular structures are essential for the analysis of vascular anatomy as well as the development of computational models for simulating biomechanics. In this paper, we present a center...