Ferulic Acid Suppresses Diabetes-Induced Atherosclerosis by Targeting Oxidative Stress, NF-κB p65/iNOS, and miRNAs Pathways.
Atherosclerosis, a major complication of diabetes mellitus, involves complex metabolic and inflammatory disruptions that remain inadequately addressed by current therapies. Ferulic acid (FA), a plant-...
Leptin in Obesity-Related Heart Failure: Pathophysiological Mechanisms and Therapeutic Implications.
Obesity is a major and potentially modifiable risk factor for heart failure (HF); however, the biological mediators linking excess adiposity to adverse cardiac remodeling and HF progression remain inc...
Prevalence and Characteristics of Cardiac Arrhythmia in Duchenne Muscular Dystrophy: A Retrospective, Single-Center Holter Electrocardiographic Monitoring Study.
BACKGROUND: In Duchenne muscular dystrophy (DMD), cardiac causes account for approximately 30% of all deaths. Therefore, evaluating cardiac function in older patients is important. In addition, curren...
Holter-ECG findings after acute ischemic stroke and TIA: A systematic analysis of the MonDAFIS randomized trial.
Holter-ECG monitoring is a critical component of post-stroke diagnostics, guiding cardiac work-up and secondary stroke prevention. Abnormal ECG findings beyond atrial fibrillation (AF) in stroke patie...
Engineered Pericyte-Targeted Extracellular Vesicles Protect Against Hypoperfusion-Induced Cognitive Impairment and Vascular Demyelination.
Pericyte dysfunction is an early hallmark of vascular cognitive impairment (VCI), yet targeted therapies remain limited. Here, we develop a bio-orthogonal approach to engineer extracellular vesicles (...
Circulating Human Epididymis Protein 4 Predicts 10-Year Mortality and Major Adverse Cardiovascular Events in Patients With Peripheral Artery Disease.
BACKGROUND: Human epididymis protein 4 (HE4) has emerged as a biomarker linked to fibrosis and cardiovascular disease. However, its prognostic relevance in peripheral artery disease (PAD) remains uncl...
Estimated Pulse Wave Velocity Is Associated with Early Renal Impairment in Non-Diabetic Hypertensive Patients.
Hypertension is a major modifiable risk factor for chronic kidney disease (CKD), accelerating renal injury by promoting arterial stiffness. Estimated pulse wave velocity (ePWV), an indicator of arteri...
Retinal vasculature-derived proteins serve as potential systemic biomarkers for diabetic retinopathy.
PURPOSE: Fibrovascular membrane (FVM), a pathological tissue causing retinal traction, represents an advanced stage of proliferative diabetic retinopathy (PDR). This study aimed to identify novel prot...
Retinal Ischemic Perivascular Lesions Screen for Vision-Threatening Diabetic Retinopathy Visualized on Ultra-Widefield Fluorescein Angiography.
PURPOSE: To validate retinal ischemic perivascular lesions (RIPLs) as an optical coherence tomography (OCT) biomarker for vision-threatening diabetic retinopathy (VTDR), using ultra-widefield fluoresc...
Interventional Management of Atrial Fibrillation in the Chronic Heart Failure Population.
Atrial fibrillation (AF) and heart failure (HF) synergistically interact to exacerbate each other. However, treatment of one entity can greatly improve management of the other. Although historically, ...
Patient-Centered Evaluation of Anticoagulation in Atrial Fibrillation.
BACKGROUND: Prior analyses of trials comparing direct oral anticoagulants (DOACs) to warfarin in atrial fibrillation (AF) have not routinely incorporated patient preferences, despite substantial varia...
Leaflets Morphology Optimization of Valved Pulmonary Arterial Conduit Based on Experimental Design.
This study investigated the influence of leaflet geometry on the hemodynamic performance of pulmonary valved conduits and optimized leaflet trimming parameters using a design of experiments (DOE) appr...
Deep Sedation With a Natural Airway is a Viable Alternative to General Anesthesia With Endotracheal Tube for Isolated Transcatheter Pulmonary Valve Implantation.
There is growing interest in utilizing deep sedation with a natural airway rather than general endotracheal anesthesia (GETA) for cardiac catheterization procedures due to the presumed hemodynamic ben...
Clinical Utility and Limitations of TAPSE in Pediatric Echocardiography: A Narrative Review.
BACKGROUND: Tricuspid annular plane systolic excursion (TAPSE) is widely used to assess right ventricular (RV) longitudinal systolic function in pediatric echocardiography; however, its reliability is...
Homozygous SGCB splice-site variant causes isolated dilated cardiomyopathy through sarcoglycan complex destabilization in East Asians.
Dilated cardiomyopathy (DCM) is a genetically heterogeneous disorder, characterized by ventricular dilatation and impaired systolic function, leading to heart failure and sudden cardiac death. Despite...
Ligand-Independent Activation of Notch1 by Cathepsin L Induces CUX1/p16(INK4a)-Dependent Endothelial Senescence Associated With Atherosclerosis.
Our post-GWAS functional analysis revealed that cathepsin L (CTSL) is an upstream regulator of CUX1, and it induces p16INK4a-dependent and atherosclerosis-associated senescence by indirectly activatin...
Current Status and Associated Factors of Discharge Readiness in Lower Extremity Peripheral Artery Disease Patients: A Cross-Sectional Study.
This study investigated the current readiness for hospital discharge (RHD) among patients with lower extremity peripheral arterial disease (PAD) following endovascular revascularization within an enha...
Influence of antihypertensive drug classes on circadian blood pressure patterns and left ventricular remodeling - a retrospective study.
BACKGROUND: Circadian blood pressure (BP) abnormalities, including nondipping and reverse-dipping patterns, are increasingly recognized as major determinants of cardiovascular target-organ damage, ind...
Associations of Long-Term Blood Pressure Burden and Variability With Kidney Function Decline.
Long-term blood pressure (BP) burden and visit-to-visit BP variability may better capture cumulative hemodynamic stress on the kidneys than single-visit BP measurements, yet evidence linking these met...
Impact of Reverse Dipper and Non-Dipper Blood Pressure Patterns on Myocardial Performance Index in Hypertensive Patients.
BACKGROUND: Abnormal nocturnal blood pressure patterns are associated with subclinical cardiac dysfunction in hypertension (HT). However, their relationship with the myocardial performance index (MPI)...