Retinal neurovascular and mitochondrial function signatures related to cognition improvement following yoga exercise in older adults.

PURPOSE: To investigate the associations between retinal neurovascular and mitochondrial function signatures and cognitive performances following a 24-week yoga intervention in healthy older adults. M...

Patients' perspectives on pulmonary rehabilitation for pulmonary hypertension in high-altitude areas: a mixed-methods study.

BACKGROUND: Chronic hypoxia at high altitudes worsens pulmonary hypertension (PH), leading to earlier symptom onset, more frequent exacerbations, and diminished quality of life. While pulmonary rehabi...

Refractory Kawasaki Disease in Infants Complicated with Giant Coronary Artery Aneurysms and Takayasu Arteritis: A Rare Case Report and Literature Review.

Kawasaki disease (KD) is a common acute systemic vasculitis in children.10% to 20% of children present with refractory KD, and a few critically ill children may develop Kawasaki disease shock syndrome...

Mortality and cardiovascular risk of triglyceride-glucose and derived indices in cardiovascular-kidney-metabolic syndrome stages 0-3: a dose-response meta-analysis.

BACKGROUND: The associations of the triglyceride-glucose (TyG) index and its derived indices with the progression of cardiovascular-kidney-metabolic (CKM) syndrome remain poorly elucidated. METHODS: W...

Intraoperative transit-time flowmetry of the superficial temporal artery directly predicts and may mitigate risk of postoperative hyperperfusion syndrome in moyamoya bypass surgery.

OBJECTIVE: To obtain perioperative cerebral blood flow measurements and assess the role of intraoperative blood flow evaluation in predicting postoperative complications. METHODS: We conducted a retro...

Cross-Trait Genome-Wide Association Study Identifies Shared Genetic Architecture Between COPD and Retinal Vascular Phenotypes.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is accompanied by systemic vascular dysfunction and microcirculatory impairment. Retinal vascular traits provide a non-invasive window into mic...

[Factors associated with the progression of mild cognitive impairment in patients with atrial fibrillation].

OBJECTIVE: To identify factors associated with the progression of vascular moderate cognitive impairment (MCI) over 36 months, based on analyses of clinical, demographic, neuropsychological, laborator...

[Molecular and systemic mechanisms of cognitive impairment associated with coronavirus infection].

Cognitive dysfunction represents a prevalent and long-lasting non-respiratory symptom following a protracted course of coronavirus infection, yet its molecular basis remains inadequately characterized...

Unmasking silent atherosclerosis in type 2 diabetes: the emerging role of adipocyte fatty acid-binding protein.

Objectives. Atherosclerosis contributes to higher mortality and morbidity in people with diabetes. Preventing future complications largely depends on the early detection of imminent atherosclerosis. T...

Predictive value of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio for in-stent restenosis after drug-eluting stent implantation in patients with coronary heart disease.

BACKGROUND & OBJECTIVE: In-stent restenosis (ISR) remains a major obstacle after drug-eluting stent (DES) implantation in patients with coronary heart disease (CHD), in which dyslipidemia play importa...

Comparative Performance of Calcium-Modification Strategies for Coronary Lesions: A Network Meta-Analysis of Randomized Trials.

INTRODUCTION AND OBJECTIVES: Calcified coronary lesions are associated with an increased risk of percutaneous coronary intervention (PCI) failure. Despite the availability of several calcium-modificat...

Bidirectional impact between cardiovascular comorbidities and heart failure: an updated position paper from the Italian society of cardiology (SIC) working group on heart failure.

Heart failure (HF) and cardiovascular (CV) diseases (CVD) are closely interconnected through a complex and bidirectional relationship. HF frequently represents the final common pathway of several CV c...

Extracellular Vesicles in the Heart-Organ Axis: From Inter-Organ Communication to Precision Nanomedicine for Heart Diseases.

BACKGROUND: Heart diseases, including myocardial infarction and heart failure, remain the leading causes of morbidity and mortality worldwide, underscoring an urgent need for innovative diagnostic and...

Diagnosis and management of very rare primary arrhythmia syndromes in children and adults: a Clinical Consensus Statement of the European Heart Rhythm Association of the ESC and the Association of Cardiovascular Nursing & Allied Professions of the ESC, endorsed by the Association for European Paediatric and Congenital Cardiology.

Very rare and ultra-rare primary inherited arrhythmia syndromes (IAS) represent a heterogeneous group of disorders associated with a significant risk of sudden cardiac death, often manifesting from fo...

Red blood cell distribution width is associated with coronary artery disease in latent tuberculosis infection: a machine learning-based study.

BACKGROUND: Latent tuberculosis infection (LTBI) is associated with an increased risk of coronary artery disease (CAD), potentially mediated by systemic inflammation. Traditional lipid-based risk mode...

Frailty and nutritional status as prognostic factors in older adults with heart failure: a public health perspective.

BACKGROUND: Heart failure is a common cardiovascular disease among older adults. Combined with frailty, it may aggravate the patient's condition and affect the prognosis. Nutritional status is importa...

A novel LepR knockout hamster model for type 2 diabetes and its complications: a complementary platform to conventional rodent models.

BACKGROUND: Type 2 diabetes (T2D) is a progressive metabolic disorder characterized by systemic metabolic dysfunction and multi-organ complications that considerably increase morbidity and mortality. ...

Metabolic, inflammatory, and lipoprotein(a)-related risk profiling for incident ASCVD: a multi-biomarker study.

AIMS: Metabolic dysfunction, inflammation, and lipoprotein(a) [Lp(a)] reflect different biomarker domains associated with atherosclerotic cardiovascular disease (ASCVD) risk. We examined the individua...

Early relative glycemic stress trajectories identify a high-risk metabolic phenotype in critically ill patients with atherosclerotic cardiovascular disease: a dual-cohort study.

BACKGROUND: The stress hyperglycemia ratio (SHR) captures acute glucose elevation relative to chronic glycemic background. However, the prognostic value of early dynamic SHR patterns in critically ill...

Geriatric syndromes and intrinsic capacity in older adults with coronary heart disease: a cross-sectional study in China.

BACKGROUND: Geriatric syndromes (GS) are highly prevalent among community-dwelling older adults with self-reported physician-diagnosed coronary heart disease (CHD), but their association with intrinsi...