Prospective Multicenter Evaluation of a Novel Active Driving System for Pediatric Ventricular Assist Device Support.
Pediatric patients with heart failure increasingly rely on ventricular assist devices as a bridge to transplantation. The Berlin Heart EXCOR Pediatric is the only durable ventricular assist device spe...
CAMK2D causes heart failure in mice with RBM20 cardiomyopathy.
Although heart disease arises from different etiologies, treatment remains largely one-size-fits-all, leaving many patients without optimal benefit, which highlights the need for cause-directed therap...
Wearable-Echo-FM: an ECG echo foundation model for 1-lead electrocardiography.
Artificial intelligence (AI) models can now detect patterns of structural heart diseases (SHDs) from electrocardiograms (ECGs), though scaling them requires the broader use of 1-lead ECGs that are now...
Artificial intelligence-enhanced electrocardiogram for the detection of rheumatic heart disease.
Rheumatic heart disease (RHD) remains the most prevalent acquired cardiovascular disease among young adults in developing countries, and there is a critical need for an efficient, affordable, and avai...
Bridging the Gaussian extremes: the economic and regulatory imperative of synthetic data in cardiovascular imaging.
Patient-physician sex concordance in cardiovascular care: context matters.
Clinical and genetic characterization of homozygous LDLR variants in familial hypercholesterolaemia: insights from two case reports.
Familial hypercholesterolaemia (FH) is an inherited lipid disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels and increased risk of atherosclerotic cardiovascular dis...
Detecting and Mitigating Bias for Inclusive and Trustworthy Clinical Research: A Scientific Statement From the American Heart Association.
Bias in clinical research affects not only the internal validity of studies but also the equitable distribution of health benefits derived from studies. Among the most impactful forms are selection bi...
Vascular Aging.
Vascular aging is a central determinant of healthy life span, not only influencing the susceptibility to cardiovascular diseases but also shaping the risk of systemic decline across multiple organs. I...
Cancer and heart failure: prevalence, incidence, and prognosis in Scotland.
Many patients with cancer develop heart failure (HF), and many patients with HF develop cancer. Inter-relationships between their natural histories are rarely reported. Health records were obtained fo...
Early ApoA-I Treatment Prevents Post-Surgical Atherosclerotic Plaque Destabilization.
Superior venous use of bridge balloon for percutaneous lead extraction in a patient with an interrupted inferior vena cava: a case report.
Transvenous lead extraction (TLE) is the gold-standard treatment for cardiac implantable electronic device removal but carries a small risk of major complications, including superior vena cava (SVC) i...
Integrating PET-Determined Global and Focal Impairment of Myocardial Flow Reserve to Enhance Cardiovascular Prognostication?
Distinct Purkinje Electrogram Phenotypes at Ventricular Fibrillation Trigger Sites in Idiopathic and Structural Heart Disease.
Purkinje fibers are established triggers of ventricular fibrillation (VF). In structural heart disease, septal fibrosis and border-zone remodeling may alter Purkinje electrograms at VF-triggering site...
Effect of intensive blood pressure and blood glucose control on cardiovascular outcomes driven by reductions in cardiovascular death and nephropathy: Win ratio analysis of ADVANCE Trial.
To re-analyse the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation) trial using the win ratio approach to better understand the relative ...
Examining the association between cardiovascular outcomes in individuals undergoing percutaneous coronary intervention with or without a preceding coronary CT angiogram.
The role of coronary CT angiography (CCTA) in improving outcomes among patients undergoing percutaneous coronary intervention (PCI) for obstructive coronary artery disease (CAD) remains unclear. A ret...
Coronary computed tomography angiography before percutaneous coronary intervention improves cardiovascular outcomes-a story too good to be true?
Automated Alerts to Improve Timely Evaluation and Treatment of Valvular Heart Disease: The ALERT Trial.
Severe aortic stenosis (AS) and mitral regurgitation (MR) are frequently undertreated and characterized by persistent sex, racial and ethnic, socioeconomic, and geographic disparities despite effectiv...
Health Care Affordability in the United States, From Crisis to Action: A Presidential Advisory From the American Heart Association.
The United States is facing a growing health care affordability crisis. In 2024, national health expenditures totalled $5.3 trillion, or $15 474 per person, accounting for 18.0% of the U.S. economy. S...
Systematic Ambulatory ECG Monitoring for Preventing Life-Threatening Cardiovascular Events Following TAVR.
Although ambulatory ECG (AECG) monitoring has been assessed after transcatheter aortic valve replacement (TAVR), its impact on life-threatening cardiovascular events remains unclear. This study aimed ...