BIN1 overexpression rescues cardiac but not skeletal muscle defects in a mouse model of caveolinopathy.
Mutations in CAV3, encoding caveolin-3, cause caveolinopathies, rare genetic disorders affecting both skeletal and cardiac muscle. Caveolin-3 contributes to T-tubule formation and excitation-contracti...
[Proteomic and metabolomic profiling of the rat model of myocardial ischemia-reperfusion injury treated with electroacupuncture].
This study aims to explore the protective effect of electroacupuncture (EA) on myocardial ischemia-reperfusion injury (MIRI) and decipher the molecular mechanism. Forty male SD rats were randomly allo...
Common Versus External Iliac Arterial Anastomosis in Kidney Transplantation: A Bicentric Retrospective Analysis of Vascular Complications and Graft Outcomes.
BACKGROUND Vascular complications remain a significant concern after kidney transplantation. While external iliac (EI) implantation is standard, common iliac (CI) implantation is occasionally performe...
Association of Clonal Hematopoiesis With Silent Brain Lesions and Cognitive Decline in Patients With Atrial Fibrillation.
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with cardiovascular disease, but its relationship with silent brain lesions and cognitive decline in patients wit...
ALKBH3 inhibition normalizes neovessels by reprogramming endothelial fate in diabetic microvasculopathy.
Diabetic microvasculopathy is a serious diabetes complication, with diabetic retinopathy (DR) being a leading cause of blindness worldwide due to immature, leaky neovessels. Antiangiogenic therapies m...
[Mechanism of herbal cake-separated moxibustion combined with atorvastatin in treating ApoE(-/-) atherosclerotic mice based on the integrin/YAP/JNK signaling pathway].
OBJECTIVES: To investigate the effects of herbal cake-separated moxibustion combined with atorvastatin on lipid metabolism, aortic pathological structure, plaque deposition, and integrin/ yes-associat...
[Electroacupuncture at "Xinshu" (BL15) improves myocardial ischemia by inhibiting the ferroptosis pathway in rats].
OBJECTIVES: To explore the role of the ferroptosis pathway of myocardial cells in electroacupuncture (EA) at "Xinshu" (BL15)-induced improvement of myocardial ischemia (MI) in rats. METHODS: A total o...
[Development of a prediction model for acute heart failure based on B-type natriuretic peptide and multiple clinical indicators in acute dyspnea patients with varying renal function levels].
Objective: To investigate the diagnostic value of B-type natriuretic peptide (BNP) for acute heart failure (AHF) in acute dyspnea patients with different renal function statuses and to develop a diagn...
Electromechanical activation and recovery wave imaging for pediatric mitral valve disease characterization.
Mitral valve (MV) disease, particularly MV prolapse (MVP) and mitral regurgitation (MR), affects 2 to 5% of the population and poses a substantial arrhythmogenic risk, with 43% of MVP patients develop...
Association of Enlarged Perivascular Spaces and Total Small Vessel Disease Burden With Kidney Function.
BACKGROUND AND OBJECTIVES: Enlarged perivascular spaces (EPVSs) in the basal ganglia (BG-EPVS) are an important marker of cerebral small vessel disease (cSVD), and EPVS in the centrum semiovale (CSO-E...
Increased LDL-C reduction with ezetimibe in ketogenic diet-induced hypercholesterolemia.
Several case reports and a meta-analysis have documented significant increases in cholesterol levels among individuals following a ketogenic diet. However, the mechanistic drivers of this phenotype re...
An uncommon side effect of statins: perioral neuropathic symptoms.
A male patient in his 60s, with a history of hypertension and hyperlipidaemia, presented with a sensation of dryness, itchiness, numbness and tingling around his mouth that started after taking atorva...
Impact of Myocardial Bridges on Long-Term Outcomes After Left Anterior Descending Chronic Total Occlusion Recanalization.
BACKGROUND: A myocardial bridge (MB) is frequently observed after recanalization of a left anterior descending coronary artery (LAD) chronic total occlusion (CTO); however, the long-term prognostic im...
Patients' experiences of mobile health tools for chronic heart failure self-management: a qualitative meta-synthesis.
OBJECTIVE: To systematically synthesise qualitative evidence on the experiences of chronic heart failure (CHF) patients using mobile health (mHealth) tools for self-management and to identify factors ...
Verapamil-sensitive fascicular ventricular tachycardia precipitated by promethazine overdose.
Verapamil-sensitive fascicular tachycardia is a type of ventricular tachycardia (VT) involving the specialised cardiac conducting tissue. Drug overdose is an important cause to consider when assessing...
Association of carbohydrate, rice, noodle and bread consumption and atrial fibrillation risk in a Japanese urban population: a prospective cohort study.
BACKGROUND AND AIM: Evidence of an association between carbohydrate intake and atrial fibrillation (AF) incidence remains limited. We investigated the association between carbohydrate and staple food ...
2-Year Patient-Centered and Clinical Outcomes of Sirolimus- Versus Paclitaxel-Coated Balloon Angioplasty in Femoropopliteal Artery Disease.
BACKGROUND: Drug-coated balloons improve outcomes after femoropopliteal angioplasty, but concerns regarding the long-term safety of paclitaxel-coated devices have prompted interest in alternative anti...
Redo-Transcatheter Aortic Valve Replacement With Self-Expanding Valves: A U.S. Registry Analysis.
BACKGROUND: Redo-transcatheter aortic valve replacement (TAVR) for failed transcatheter heart valves is expected to increase, but data on outcomes with self-expanding valves remain limited. OBJECTIVES...
Outcomes of Supra-Annular vs Intra-Annular Self-Expanding Valves in Valve-In-Valve Transcatheter Aortic Valve Replacement.
BACKGROUND: Self-expanding valves appear to have superior hemodynamics compared with balloon-expandable valves for valve-in-valve transcatheter aortic valve replacement (ViV-TAVR). OBJECTIVES: This st...
Managing Cardiogenic Shock in the Era of Multimodal Mechanical Support: Bridging to Transplant or Recovery.
PURPOSE OF REVIEW: To review the contemporary management of cardiogenic shock in the era of multimodal temporary mechanical circulatory support, with emphasis on phenotype-guided device selection, ser...