The Binding of Fibroblast Growth Factor 23 (FGF23) to FGF Receptor-αKlotho Complex Increases Sinoatrial Electrical Activity.
AIM: This study aims to investigate whether the Fibroblast Growth Factor 23 (FGF23) modulates the electrical activity of sinoatrial (SAN) cells. The canonical function of FGF23 is to regulate body pho...
Hypotonicity-Induced WNK1 Phosphorylation Prevents H(2)O(2)-Induced Apoptosis in Vascular Smooth Muscle Cells.
Vascular smooth muscle cells (VSMCs) are essential for maintaining arterial wall integrity, with their associated apoptosis critically involved in cardiovascular diseases. Intracellular chloride anion...
Oxytocin Affects Barriergenesis in the Blood-Brain Barrier and the Blood-Cerebrospinal Fluid Barrier In Vitro Monoculture Transwell Models.
The integrity of the brain's barrier systems-the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB)-is crucial for central nervous system homeostasis. Oxytocin (OXT), a neuropepti...
Finerenone Alleviates Cardiac Microvascular Injury and Neutrophil Extracellular Traps Formation in Diabetic Cardiomyopathy via Regulating AKT1 Phosphorylation.
BACKGROUND: Diabetes mellitus is commonly featured with cardiac microvascular dysfunction and chronic low-grade inflammation, contributing to the progression of diabetic cardiomyopathy (DCM). Finereno...
The impact of switching to tenofovir alafenamide on lipid profile and renal function in chronic hepatitis B: a retrospective cohort study.
OBJECTIVE: Tenofovir alafenamide (TAF) offers favorable renal safety compared with tenofovir disoproxil fumarate (TDF) in chronic hepatitis B (CHB), but its long-term metabolic effects remain unclear....
Assessing clinical outcomes in cirrhotic patients with thromboembolic complications.
BACKGROUND: Cirrhosis produces a rebalanced hemostatic state that predisposes patients to bleeding and thrombosis. We evaluated hepatic outcomes associated with deep vein thrombosis (DVT), pulmonary e...
POU2F1 promotes hypertensive cardiac fibrosis by regulating mitochondrial homeostasis through PINK1/Parkin‑dependent mitophagy.
Hypertension‑induced cardiac fibrosis is a major risk factor for heart failure; although disrupted mitochondrial homeostasis has been confirmed to serve a critical role in the pathological process, it...
The additive value of coronary calcium in identifying cardiovascular risk in ageing people with HIV.
In people without HIV, raised coronary artery calcium scores (CACS) are linked to increased cardiovascular risk. HIV is associated with elevated CACS, but risk factors beyond smoking and diabetes are ...
Complications of Transcatheter Aortic Valve Replacement: Contemporary Prevention, Recognition, and Management.
This review summarizes contemporary prevention, recognition, and management of major complications after transcatheter aortic valve replacement. The article emphasizes anatomy-specific planning with m...
Hypoattenuated Leaflet Thickening: Pathophysiology, Clinical Implications, and Its Role in Structural Valve Longevity.
The expansion of transcatheter aortic valve replacement (TAVR) into younger and lower-risk populations has heightened attention toward long-term valve durability. Hypoattenuated leaflet thickening (HA...
Conduction Disturbances and Pacing after Transcatheter Aortic Valve Replacement: Mechanisms, Risk Stratification, and Management.
Conduction disturbances are common after transcatheter aortic valve replacement and significantly influence postprocedural management and outcomes. These abnormalities arise from the close anatomic re...
Valve-In-Valve Transcatheter Aortic Valve Replacement: Advances in Planning, Technique, and Lifetime Management.
Valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) has emerged as a key reintervention strategy for failed surgical bioprostheses. Meticulous preprocedural planning with computed tomogra...
Transcatheter Aortic Valve Replacement for Native Aortic Regurgitation.
Aortic regurgitation (AR) is a common valvular heart disease with an estimated prevalence of greater than 4% among patients aged greater than 65 years in some series. If left untreated, AR is associat...
Transcatheter Aortic Valve Replacement with a Self-expanding Prosthesis.
Self-expanding transcatheter valves have evolved significantly into mature therapeutic platforms supported by randomized evidence across the spectrum of surgical risk. The most consistent advantages o...
Alternative Access for Transcatheter Aortic Valve Replacement: A Comprehensive Updated Review.
Transfemoral is the most widely used and remains the preferred approach to perform Transcatheter aortic valve replacement (TAVR) in the vast majority of patients because of its superior clinical outco...
Treatment of Bicuspid Aortic Valve Stenosis Using Transcatheter Heart Valves.
The paucity of data from randomized clinical trials regarding the use of transcatheter aortic valve replacement (TAVR) in bicuspid aortic valve anatomy due to exclusion from pivotal studies continues ...
Balloon-Expandable Transcatheter Aortic Valve Replacement: A Comprehensive Review of Current Evidence and Clinical Outcomes.
This article outlines the transformative impact of transcatheter aortic valve replacement (TAVR) since its first successful human use in 2002, redefining the management of severe aortic stenosis. Trad...
Beyond the First Valve: A Longitudinal Framework for Aortic Valve Replacement Selection.
The growing population of patients expected to outlive their index aortic valve replacement (AVR) demands a fundamental shift in treatment planning to one that treats the first valve as the opening co...
Emergency department blood pressure elevations frequently occur without documented hypertension diagnosis.
BACKGROUND: High blood pressure readings (HBPRs) are common in emergency department (ED) patients, but the frequency of HBPRs among patients without a documented diagnosis of hypertension (DDxHTN) is ...
Blood pressure phenotypes and hypertension-associated cardiac damage.
BACKGROUND: The aim of this study was to characterize hypertension-associated cardiac damage in the blood pressure (BP) phenotypes sustained normotension (SNT), white coat hypertension (WCHT), masked ...