Proteomic Mendelian randomization and machine learning reveal causal plasma biomarkers in cardiorenal comorbidity.

BACKGROUND: Chronic kidney disease (CKD) significantly increases the risk of coronary artery disease (CAD), but the causal plasma proteins linking these conditions are poorly understood. This study ai...

Zexie decoction alleviates hyperlipidemia through modulation of the PPAR signaling pathway and lysophospholipid metabolism.

CONTEXT: Zexie Decoction (ZXD) is a classical traditional Chinese medicine prescription that has long been used for the treatment of hyperlipidemia. However, its material basis and underlying mechanis...

Causal associations between antibody-mediated immune responses to infectious agents and cardiovascular inflammatory diseases: A Mendelian randomization study based on UK Biobank and FinnGen.

A two-sample Mendelian randomization study was performed to evaluate causal associations between 46 pathogen-specific antibodies and six cardiovascular inflammatory diseases: myocarditis, pericarditis...

Predicting major adverse cardiovascular and cerebrovascular events in chronic heart failure: a machine learning study.

BACKGROUND: Heart failure (HF) is a clinical syndrome characterized by impaired cardiac diastolic and systolic function due to structural or functional damage to the myocardium. HF represents the end-...

Cost-effectiveness and budget impact of ezetimibe-atorvastatin single-pill combination versus free combination in Chinese adults with hypercholesterolemia.

BACKGROUND: Hypercholesterolemia imposes a growing cardiovascular burden in China, yet low-density lipoprotein cholesterol (LDL-C) target attainment remains low. The single-pill combination (SPC) of e...

Associations of atherogenic index of plasma related indices with subclinical carotid atherosclerosis.

BACKGROUND: Evidence regarding the relationships between atherogenic index of plasma (AIP)-related indices and carotid atherosclerosis (CA) is limited. METHODS: A total of 59123 participants from the ...

Usefulness of metabolic score for insulin resistance to predict restenosis after coronary stent implantation.

OBJECTIVE: The aim of this study was to evaluate the clinical forecasting potential of the Metabolic Score for Insulin Resistance (METS-IR) as a reliable predictor for in-stent restenosis (ISR) among ...

A global model for symptomatic obstructive hypertrophic cardiomyopathy to assess the cost-effectiveness of mavacamten: results from a Dutch societal perspective.

OBJECTIVES: To explore the cost-effectiveness of mavacamten + beta-blocker/calcium channel blocker therapy (BB/CCB) versus BB/CCB monotherapy for the treatment of symptomatic obstructive hypertrophic ...

Clinical impact of an EHR-integrated hyperkalemia management system: a real-world study of 10,934 episodes.

This retrospective study analyzed 10,934 hyperkalemia episodes to compare outcomes between the hyperkalemia routine group and the hyperkalemia standardized group, the latter managed with a strategy su...

IGFBP-1 combined with CHRDL1 in mid-pregnancy serum for predicting fetal growth restriction in late pregnancy among women with gestational hypertension: a prospective nested case-control study.

OBJECTIVE: To investigate the association between mid-pregnancy serum levels of insulin-like growth factor binding protein-1 (IGFBP-1) and chordin-like 1 (CHRDL1) and the occurrence of fetal growth re...

Effect of the modified RADAR, No-touch, and conventional techniques on arteriovenous fistula outcomes.

OBJECTIVE: Low primary patency rates represent a major problem of radiocephalic arteriovenous fistula (RC-AVF). No-touch techniques and radial artery deviation and reimplantation (RADAR) were reported...

Development and internal validation of a preprocedural prediction model for failed umbilical venous catheterization in neonates.

OBJECTIVE: Umbilical venous catheterization (UVC) may fail because of resistance during catheter advancement, malposition, impaired catheter function, or procedure termination. Preprocedural predictor...

Association of atherogenic index of plasma with urine albumin-to-creatinine ratio in Chinese urban adults: a cross-sectional study.

The association between the atherogenic index of plasma (AIP) and urine albumin-to-creatinine ratio (UACR) has not been fully elucidated in large-scale populations. This study aimed to systematically ...

Real-world burden of hypertrophic cardiomyopathy on healthcare use and health-related quality of life in Italy, Spain, and the United States.

BACKGROUND AND AIMS: Hypertrophic cardiomyopathy (HCM) is a chronic, progressive, genetic heart disease characterized by hypercontractility and hypertrophy. As treatment options evolve, characterizing...

Antihypertensive drugs and arteriovenous fistula flow rates among patients on maintenance hemodialysis in Egypt.

Vascular access dysfunction is a major cause of morbidity among maintenance hemodialysis (HD) patients. Calcium channel blockers (CCBs) may affect vascular remodeling; however, their impact on arterio...

Association between chronotypes and comorbidities in obstructive sleep apnea: The age effect.

BACKGROUND: Obstructive sleep apnoea (OSA) is associated with increased cardiometabolic risk. Although a chronotype, a phenotypic marker of circadian rhythm, appears to influence this relationship, th...

Cost-effectiveness analysis of apixaban compared with other oral anticoagulants for the treatment of non-valvular atrial fibrillation in a Belgian healthcare setting.

AIMS: Direct oral anticoagulants (DOACs) are recommended for stroke and systemic embolism prevention in patients with non-valvular atrial fibrillation (NVAF) in preference to vitamin K antagonists (VK...

Chromosomal abnormalities and pregnancy outcomes in 350 pregnancies with prenatally diagnosed aberrant right subclavian artery: a phenotype-based retrospective cohort study.

BACKGROUND: Aberrant right subclavian artery (ARSA) is the most frequent aortic-arch branching variant on prenatal sonography, and its clinical relevance is governed by the phenotypic context in which...

Diastolic contributors in cardiomyocytes of a cardiometabolic HFpEF-like mouse model.

Three main contributors to cardiomyocyte diastolic stiffness are (1) passive sarcomere stiffness, (2) microtubules, and (3) diastolic crossbridges (XBs), the XBs that are present in the diastolic phas...

Prunasin alleviates OGD/R-induced injury in H9c2 cardiomyocytes via SRC/EGFR-AKT-FoxO-mediated mitochondrial quality control.

BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) is still difficult to manage clinically, mainly due to limited effective strategies that can simultaneously address oxidative stress, mitochon...