Nighttime blood pressure versus non-dipping for predicting asymptomatic organ damage in young individuals.
BACKGROUND: Circadian blood pressure (BP) phenotypes are associated with cardiovascular risk, though understudied in youth. This study in young individuals investigated the association of nighttime BP...
Wearable wrist-watch type cuff oscillometric blood pressure monitors: consensus statement by the European Society of Hypertension Working Group on blood pressure monitoring.
Wearable wristwatch-type cuff oscillometric blood pressure (BP) monitors represent a new category of BP devices and are the first wearable monitors to use established cuff-oscillometric BP measurement...
Theoretical foundations of bloodletting therapy for primary hypertension in the southern school of Tibetan medicine: insights from Qinghai-Tibet Plateau medical theory.
Primary hypertension (PH) remains a significant contributor to global morbidity and mortality. While contemporary biomedical treatments are widely utilized, traditional medical systems such as Tibetan...
A modified model of cardiac reverse remodeling following abdominal aortic banding and debanding in rats.
OBJECTIVE: Cardiac reverse remodeling (RR) after pressure unloading has been widely studied using abdominal aortic banding (AB) and debanding (DB) models. However, the DB procedure is technically chal...
Pulmonary function and endothelial damage in patients undergoing renal replacement therapy: a cross-sectional study.
OBJECTIVE: To compare pulmonary function and biomarkers of endothelial injury between hemodialysis patients with end-stage renal disease (ESRD) and kidney transplant (KT) recipients. METHODS: Cross-se...
Inhibition of Dyrk1a attenuates type 1 diabetic cardiomyopathy via anti‑ferroptosis.
Diabetic cardiomyopathy (DCM) is a major complication of type 1 diabetes mellitus (T1DM) with limited treatment options. Dyrk1a is involved in multiple diseases, comprising neurodegenerative disorders...
Research progress on drugs targeting mitochondria‑associated membranes for the treatment of atherosclerosis (Review).
Mitochondria‑associated membranes (MAMs) are specialized contact sites between the endoplasmic reticulum and mitochondria, and serve as the structural foundation for material exchange and signal trans...
Re: Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial.
This correspondence addresses the EXERDIET-HTA substudy by Aparicio and colleagues, which concludes that 16 weeks of aerobic exercise plus a hypocaloric DASH diet reduced serum leptin more than diet w...
Natural polysaccharides modulate the microbiota-gut-brain axis through multiple targets: A new perspective on the pathogenesis and treatment of depression.
Depression is increasingly understood as a systemic disorder involving microbiota-gut-brain axis (MGBA) dysfunction rather than only central monoaminergic imbalance. Gut microbial dysbiosis, barrier d...
GPR30 Functions as a Shared Inhibitory Signal for Both Pericyte-Mediated Angiogenesis and Oligodendrocyte Myelination.
Myelinogenesis is insufficient in numerous myelin-related diseases in the CNS, leading to functional impairments. Myelinogenesis couples with angiogenesis to ensure adequate need of oxygen and nutrien...
Role of microbial metabolites in the pathogenesis of hypertensive disorders of pregnancy: From short‑chain fatty acids to tryptophan metabolites (Review).
Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and perinatal morbidity worldwide, and their pathogenesis involves complex interactions among vascular dysfunction, placental ...
Müller Glia-Vasculature Interactions in the Developing Retina.
Coordinated signaling among neurons, glia, and the vasculature is essential for nervous system development. In the developing retina, spontaneous cholinergic retinal waves are the primary source of ne...
Post‑translational modifications in atherosclerosis: Roles, mechanisms and therapeutic potential (Review).
Atherosclerosis (AS) is the principal pathological basis of cardiovascular disease and develops through the coordinated progression of endothelial dysfunction, lipid accumulation, macrophage foam‑cell...
Association between periodontitis and heart failure: Mechanisms and clinical implications (Review).
Periodontitis, a common oral disease, is increasingly recognized for its potential impact on systemic health, particularly its association with heart failure (HF). HF is a complex clinical syndrome wi...
Effect of Buerger-Allen Exercises on Lower Extremity Perfusion in Diabetes Mellitus Patients Undergoing Coronary Artery Bypass Grafting With Saphenous Vein Harvesting: A Randomized Controlled Trial.
BACKGROUND & PURPOSE: Patients with diabetes mellitus undergoing coronary artery bypass grafting (CABG) with saphenous vein harvesting are at increased risk of impaired lower extremity perfusion and w...
Formulation and evaluation of sustained-release pitavastatin-loaded chitosan nanoparticles for enhanced anti-hyperlipidemic activity.
BACKGROUND: Pitavastatin (PVN), a BCS class-II drug, exhibits poor aqueous solubility leading to limited oral bioavailability and therapeutic efficacy. OBJECTIVES: This study aimed to enhance the solu...
Berberine ameliorates doxorubicin-induced cardiac toxicity via regulation of the SNHG14/miR-9-5p/PDK4 axis.
BACKGROUND: Doxorubicin (Dox) has limited clinical application due to its cardiotoxicity. Berberine (Ber) counteracts Dox-induced myocardial injury. OBJECTIVES: This study uncovers molecular mechanism...
Calcium-channel blockade-mediated blood pressure-lowering and vasorelaxant effects of Brassica oleracea.
BACKGROUND: Brassica oleracea L. (Brassicaceae), commonly known as cabbage, is usually used for dietary purposes and is also known for many medicinal uses, including blood pressure. OBJECTIVES: The cu...
Effects of curcumin and nicorandil on nilotinib-induced QT interval prolongation in rats: A telemetry-based study.
BACKGROUND: Long QT syndrome (LQTS) is characterized by QT prolongation, ventricular arrhythmias and sudden death. Nilotinib (Nilo), a tyrosine kinase inhibitor used in chronic myeloid leukemia, prolo...
Antihypertensive and vasorelaxant effects of 2-methoxystypandrone mediated via multiple vascular mechanisms.
BACKGROUND: 2-Methoxystypandrone (2-MS), a naphthoquinone from Reynoutria japonica Houtt., has diverse pharmacological activities. However, its antihypertensive and vascular effects remain unexplored....