Hypertensive disorders during pregnancy and cognitive outcomes in children: the ALSPAC study.
OBJECTIVE: This study aimed to examine the associations between hypertensive disorders during pregnancy and intelligence quotient (IQ) in children at the ages of 8 and 16 years. METHODS: Our study sam...
Glycosylation in gut-brain communication: from the intestinal barrier and microbiota to immune and neural signaling.
The gut-brain axis is a complex bidirectional communication network linking the gastrointestinal tract and the central nervous system. Its dysregulation is closely associated with a wide range of gast...
Left ventricular hypertrophy as a predictor of adverse maternal and neonatal outcomes in chronic hypertension in pregnancy: a multicenter study.
OBJECTIVE: The impact of chronic hypertension (CHTN) combined with left ventricular hypertrophy (LVH) on adverse maternal and fetal pregnancy outcomes remains unclear. METHODS: This multicenter retros...
Microbial metabolite-driven mechanisms linking the gut microbiome to atherosclerosis: multi-omic and translational perspectives.
Atherosclerotic cardiovascular disease remains the leading cause of mortality worldwide, and a substantial residual risk persists despite optimal management of traditional risk factors. Increasing evi...
Diagnostic value of serum miR-4677-3p combined with ultrasound in endometriosis.
OBJECTIVE: Endometriosis faces diagnostic delays due to the lack of tools for diagnostic evaluation. The value of miR-4677-3p combined with ultrasound in the diagnosis of endometriosis. METHODS: 110 h...
Inter-ankle systolic blood pressure difference is associated with microalbuminuria in non-diabetic hypertension patients: A cross-sectional study from two cohorts.
This cross-sectional study aimed to analyze whether inter-ankle systolic blood pressure difference (sIAND) was associated with different stages of hypertensive renal damage. 1,658 and 831 nondiabetic ...
Lactate/AARS1-mediated H3K18la in the modulation of ACSL4 transcription to trigger ferroptosis in myocardial ischemia reperfusion.
OBJECTIVE: Hypertension serves as a pivotal risk factor for myocardial ischemia reperfusion injury (MIRI). Reciprocally, MIRI exacerbates hypertension by inducing oxidative stress, inflammatory respon...
Ultrasound-triggered platelet vehicles loading fluorescein for targeted sonodynamic therapy of glioblastoma.
Glioblastoma (GBM), the deadliest primary brain malignancy, resists treatment because of the blood‒brain barrier (BBB) and intrinsic resistance mechanisms. Fluorescein (FL), a clinically approved fluo...
Does hydrochlorothiazide-associated hyponatremia in hypertensive individuals have a genetic origin?
OBJECTIVE: Hyponatremia is one of the most common electrolyte disorders in clinical practice and is frequently observed following thiazide use. Advanced age and female gender are implicated in the eti...
Beyond the pump: integrating the heart's endocrine function into early medical education.
BACKGROUND: The heart is commonly introduced in early medical education through its structural, mechanical, and electrophysiological roles. Although this framing remains foundational, it may underemph...
Dnmt1 associated Gja1 promoter methylation changes are implicated in Cx43 remodeling during acute myocardial ischemia/reperfusion injury.
DNA methylation has traditionally been regarded as a stable epigenetic modification. However, emerging evidence indicates that oxidative and genotoxic stress can induce locus-specific methylation chan...
Adiponectin improves the aortic dissection by inhibiting inflammatory cell infiltration and macrophage pyroptosis.
OBJECTIVE: Aortic dissection (AD) is a fatal cardiovascular emergency that is predominantly induced by long-term uncontrolled hypertension. MATERIALS AND METHODS: The mouse AD model was established by...
Gut microbiome drives glycodeoxycholic acid-mediated attenuation of hypertension.
Gut microbiota and bile acids are increasingly recognized to regulate blood pressure, but the mechanisms remain unclear. Takeda G-protein coupled receptor 5 (TGR5) is a major receptor for secondary bi...
Electroacupuncture for essential hypertension: Mechanistic insights, current clinical evidence, and translational challenges.
BACKGROUND: Essential hypertension (EH) remains a leading modifiable risk factor for cardiovascular morbidity and mortality worldwide. Electroacupuncture (EA), combining traditional acupuncture with p...
Cardiovascular-kidney-metabolic syndrome through the lens of gut‑derived uremic toxins.
Cardiovascular-Kidney-Metabolic (CKM) syndrome represents a complex, interconnected cluster of cardiovascular disease, chronic kidney disease, and metabolic disorders such as obesity and type 2 diabet...
The cysteine metabolic regulation through CSE-transsulfuration pathway is essential in iron-induced oxidative damage of heart.
OBJECTIVES: Iron overload (IO) cardiomyopathy is a major cause of mortality in patients with iron overload disorders. This study investigates the role of cystathionine γ-lyase (CSE), a key enzyme in t...
Low-intensity pulsed ultrasound combined with microbubbles enhances amphotericin B delivery across the blood-brain barrier for improved therapy of cryptococcal meningitis.
Cryptococcal meningitis (CM), a life-threatening fungal infection of the central nervous system, faces therapeutic challenges due to poor blood‒brain barrier (BBB) penetration of amphotericin B. This ...
Efficient brain delivery and sustained retention of antibodies via dual targeting of blood-brain barrier and intra-brain proteins.
Efficient delivery of therapeutic antibodies to the brain has been increasingly achieved using receptor-mediated transcytosis (RMT) approaches such as transferrin receptor (TfR)-mediated shuttle syste...
Environmental risk factors for false-positive results in newborn screening for primary carnitine deficiency: a multicenter large-scale retrospective cohort study.
OBJECTIVE: To identify environmental risk factors contributing to false-positive results in newborn screening for primary carnitine deficiency (PCD) and to evaluate their predictive performance. METHO...
Genetic overlap between estimated glomerular filtration rate and cardiovascular disease identifies potential targets for cardiorenal syndrome.
Heart and kidney diseases frequently coexist, but the genetic basis of this relationship remains unclear. We analyzed genetic data from large-scale studies to investigate how kidney function (estimate...