Cervical Heterotopic Mouse Heart Transplantation using End-to-side Anastomosis Technique to Study Transplant Immunology.

Murine heterotopic heart transplantation is a critical preclinical model in transplantation research. Cervical heterotopic heart transplantation in mice offers distinct advantages, including direct vi...

Metabolomic Lipid Profile Changes in Patients with Heart Failure Undergoing Oral Nutritional Supplements Enriched with the Omega-3 (n-3) Polyunsaturated Fatty Acids and Mediterranean Diet.

UNLABELLED: Chronic inflammation and metabolic dysregulation of heart failure (HF) often result in sarcopenia. The combined effect of Mediterranean diet (MD) and omega-3 polyunsaturated fatty acids on...

Indoxyl Sulfate, a Gut Microbiota-Derived Metabolite, Modulates Hepatic Cholesterol Metabolism via SREBP-2/HMG-CoA Reductase Upregulation in Rats.

BACKGROUND: A high-fat diet (HFD) contributes to cardiometabolic disease. Gut microbiota-derived metabolites may participate in this process, but their contribution to lipid regulation is not well def...

Gut Microbiota and Atherosclerotic Plaque Instability: Cellular and Molecular Mechanisms.

Atherosclerosis is a chronic multifactorial inflammatory vascular disease and the major risk factor for cardiovascular diseases (CVDs), characterized by arterial wall thickening, loss of arterial elas...

Extracellular Traps in Coronary Thrombus Aspirates from Patients with ST-Elevation Myocardial Infarction.

The formation of extracellular traps (ETs) through ETosis has emerged as a key mechanism in immunothrombosis. However, the temporal dynamics and clinical significance of ETosis in coronary thrombi of ...

Hypertension up-regulates yes-associated protein expression in the penile corpus cavernosum and suppresses erectile function in spontaneously hypertensive rats.

INTRODUCTION: Hypertension is an important risk factor for erectile dysfunction. Yes-associated protein (YAP) is a multifunctional protein involved in diverse biological processes; whether hypertensio...

Clinical outcomes of continuing vs. discontinuing oral anticoagulation after atrial fibrillation ablation: an updated systematic review and meta-analysis of observational studies and randomized controlled trials.

AIMS: Continuation of oral anticoagulation (OAC) after successful atrial fibrillation (AF) ablation remains debated. With recent randomized controlled trials addressing this question, an updated meta-...

Leisure screen time, cardiometabolic pathways, and frailty: A two-step Mendelian randomization analysis.

Whether leisure screen time (LST) is causally related to frailty remains uncertain. We used Mendelian randomization (MR) to examine the association of genetically proxied LST with frailty risk and to ...

SLIT2 and ANGPTL3 as putative mediators linking obesity to atrial fibrillation: A Mendelian randomization study.

The observational association between obesity and atrial fibrillation has been well-established. However, its causal mediators underlying this association remain unclear. This study aimed to investiga...

Endoscopic endonasal resection of the cavernous sinus medial wall for functioning pituitary adenomas: A propensity score-matched retrospective cohort study.

Functioning pituitary adenomas (FPAs) account for 63% to 85% of pituitary adenomas. Although endoscopic endonasal surgery targets biochemical remission and reduced recurrence, cavernous sinus medial w...

The predictive value of the systemic immune-inflammation index in chronic thromboembolic pulmonary hypertension.

The systemic immune-inflammation index (SII) is associated with the severity and progression of vascular disorders. However, the relationship between SII and chronic thromboembolic pulmonary hypertens...

Impact of folic acid supplementation on cardiovascular risk among individuals with hemorrhagic stroke: A prospective study.

This study explored the association between enalapril-folic acid treatment and the likelihood of developing cardiovascular disease (CVD) in patients with hemorrhagic stroke combined with H-type hypert...

Effect of motivational behavioral change-integrated rehabilitation nursing on recovery and prognosis in patients with hypertension and diabetic foot ulcers.

A retrospective analysis was conducted on 72 patients with hypertension complicated by diabetic foot ulcers who were treated in our hospital between January 2020 and February 2023. According to the nu...

Association between blood cadmium and prevalent coronary heart disease in NHANES 2013 to 2014: A cross-sectional study with machine-learning analyses.

Cadmium is a toxic environmental metal, but its association with prevalent coronary heart disease (CHD) remains uncertain. We examined whether blood cadmium concentrations were associated with prevale...

Association between the Dietary Index for Gut Microbiota and all-cause mortality in coronary heart disease: A retrospective cohort analysis of NHANES (2005-2018).

The Dietary Index for Gut Microbiota (DI-GM) is a novel metric assessing diet quality in relation to gut microbial composition. However, its association with all-cause mortality (ACM) in coronary hear...

Therapeutic strategies of traditional Chinese medicine for chronic heart failure: from active ingredients to herbal formulations.

Chronic heart failure (CHF) remains a global health challenge with complex pathological mechanisms, including inflammation, oxidative stress, mitochondrial dysfunction, myocardial remodeling, ferropto...

Association between gout duration and subclinical carotid arterial stiffness in male patients with gout: A retrospective observational study.

Gout has been associated with an increased risk of cardiovascular disease, but direct evidence on carotid vascular changes in patients with gout remains limited. This study evaluated carotid arterial ...

Iron deficiency in primary care patients with heart failure: a cross-sectional study of the heart failure in Southern Sweden (HISS) cohort.

BACKGROUND: Iron deficiency is a common and clinically relevant comorbidity in heart failure, associated with reduced functional capacity, higher symptom burden, and increased hospitalisation risk. Mo...

Development of age-specific and sex-specific blood pressure norms and their associations with lipid profile in children aged 6-16 years from urban Bengaluru: a cross-sectional study.

INTRODUCTION: Paediatric hypertension is a significant health problem, with elevated childhood blood pressure (BP) linked to adult hypertension and increased cardiovascular risk. Existing reference gu...

PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction.

PCSK5 (proprotein convertase subtilisin/kexin 5) is essential for heart development. However, its role in myocardial infarction (MI) remains unexplored. In this study, we found that the plasma levels ...