Arterial shear rate determines the structure and mechanical properties of whole-blood clots.

BACKGROUND: Arterial thrombosis arises under high shear conditions and is a leading cause of ischemic stroke and myocardial infarction. The local hemodynamic environment during the formation of the th...

Efficient estimation for deep generalized accelerated hazards models with interval-censored data.

For the analysis of interval-censored data, we propose a deep generalized accelerated hazards model. This model is designed to facilitate a detailed exploration of the relationship between various ris...

Podocyte dysfunction in kidney diseases: Mechanisms and therapeutic advances.

Podocytes are terminally differentiated visceral epithelial cells that form the outermost layer of the glomerular filtration barrier. Through their foot processes and slit diaphragm structures, podocy...

Postoperative De Ritis Ratio as a Predictor of Adverse Outcomes After Combined Aortic and Mitral Valve Replacement: A Retrospective Cohort Study.

BACKGROUND: Double valve replacement (DVR) of both the aortic and mitral valves is a technically demanding cardiac procedure associated with significant risks, including extended cardiopulmonary bypas...

Primary Leiomyosarcoma of the Superior Vena Cava: A Rare Case Report.

Leiomyosarcoma of the superior vena cava (SVC) is an exceptionally rare vascular tumor. Fewer than 20 cases were reported worldwide. Because of the nonspecific nature of the presenting symptoms and th...

Comparison of monthly bleeding rates after direct oral anticoagulant initiation for venous thromboembolism and atrial fibrillation.

BACKGROUND: Direct oral anticoagulants (DOACs) are commonly used for the treatment of atrial fibrillation (AF) and venous thromboembolism (VTE) but increase the risk of bleeding. OBJECTIVES: We aimed ...

Family-based interventions for optimal lipid outcomes in adults: A cluster randomized controlled trial in India.

BACKGROUND: Dyslipidemia substantially increases the risk of cardiovascular disease (CVD), particularly among those with a strong family history. OBJECTIVE: To evaluate the longitudinal impact of the ...

Prevalence of disease in 549 older cats undergoing health screening at two United Kingdom-based veterinary clinics.

BACKGROUND: Risk of some diseases of cats increases with age, including chronic kidney disease (CKD) and hyperthyroidism, but clinical signs can be dismissed by caregivers as age-related changes. HYPO...

Large animal models of right heart failure due to pulmonary hypertension: a bridge to translational success.

Right heart failure drives morbidity and mortality in pulmonary arterial hypertension (PAH). At present, there are no chronic pharmaceutical interventions that directly augment right heart function in...

Postoperative Atrial Fibrillation Following Non-Cardiac Surgery: The Impact of Medical History and Surgical Type.

BACKGROUND: Postoperative atrial fibrillation (POAF) is well recognized after cardiac surgery; however, its incidence and clinical course following non-cardiac surgery (NCS) remain unclear. OBJECTIVES...

Frequency and Patterns of Electrocardiogram Testing among High-risk Elderly Individuals.

BACKGROUND: Electrocardiogram (ECG) may detect atrial fibrillation (AF), but the true rate of ECG performance is unknown. OBJECTIVES: To explore the performance rate of ECG testing in patient populati...

The expanding role of peptides in cardiovascular care.

Peptides have emerged as key regulators of cardiovascular physiology and increasingly important tools in the diagnosis and management of cardiovascular disease (CVD). Endogenous peptide systems, inclu...

Diagnostic Role of Celiac Plexus Block in Assessing Eligibility for Corrective Surgery in a Case of Median Arcuate Ligament Syndrome.

BACKGROUND: Median arcuate ligament syndrome (MALS) is an uncommon cause of postprandial abdominal pain that can be difficult to diagnose, especially in children. CASE REPORT: We report a 14-year-old ...

Effect of Gene Expression Profiling Surveillance Compared With Endomyocardial Biopsy On Tricuspid Regurgitation in Patients with Heart Transplant.

OBJECTIVES: Gene expression profiling is an emerging noninvasive method for rejection surveillance in heart transplants. Tricuspid regurgitation prevalence increases over time after heart transplant, ...

[Migration of a contraceptive implant into the pulmonary artery].

Each year, in Belgium and Europe, thousands of contraceptive implants are inserted, representing an effective and long-lasting method of contraception. Their ease of use and prolonged duration of acti...

[Coronary artery anomalies associated with bicuspid aortic valve].

Bicuspid aortic valve (BAV) is the most common congenital heart disease. It is often associated with aortic abnormalities and, more rarely, with coronary anomalies that may influence surgical strategy...

[Mechanism of vitexin in treating acute hyperlipidemia by combination of metabolomics and network pharmacology].

The study aims to investigate the mechanism of vitexin in treating acute hyperlipidemia through a combination of network pharmacology, molecular docking, and metabolomics approaches. An acute hyperlip...

[Research advance on regulation of SREBP pathway by TCM in prevention and treatment of hyperlipidemia].

Hyperlipidemia(HLP) is a significant independent risk factor for the occurrence and development of cardiovascular and cerebrovascular diseases. Currently, the common clinical lipid-lowering agents inc...

[Epidemiological characteristics and changes of metabolic abnormalities among students aged 6-14 in Beijing in 2015 and 2019].

OBJECTIVE: To study the epidemiological characteristics and changes of central obesity, abnormal blood glucose, and dyslipidemia among students aged 6-14 in Beijing. METHODS: A multi-stage stratified ...

[Effects of Zuopi Pills on ApoE~(-/-) atherosclerotic mice by inhibiting ferroptosis via ACSL4/LPCAT3/ALOX15 pathway].

This study integrated network pharmacology, computational simulation, spatial transcriptomics, and animal experiments to systematically reveal the multi-level mechanism of the traditional Chinese medi...