Investigating Retinal Microvascular Changes Using OCT-Angiography: The Role of Oxidative Stress and Endothelial Dysfunction in Hypertensive Nephropathy.

Background and Objectives: Arterial hypertension is a major cause of systemic microvascular damage involving target organs such as the kidneys and retina. Because the retinal and renal microcirculatio...

Serial dual-wavelength illumination for retinal vessel oximetry using a conventional fundus camera: a proof-of-concept study.

PURPOSE: Retinal vessel oximetry requires fundus images at two wavelengths with different hemoglobin absorption characteristics. Simultaneous acquisition using one-chip color cameras may be affected b...

Longitudinal progression of tissue remodeling in experimental pulmonary hypertension is accompanied by a continuously increasing re-expression of extra domain A-containing fibronectin.

Pulmonary hypertension (PH) is a progressive disease characterized by pulmonary vascular remodeling and increasing right ventricular (RV) afterload. Extracellular matrix (ECM) remodeling is central to...

Type 2 diabetes is associated with clinical progression of aortic stenosis: a nationwide retrospective study in Sweden.

Patients with type 2 diabetes mellitus (T2DM) have elevated risk for aortic stenosis (AS). The impact of diabetes on prognosis and clinical progression in AS is not well documented. In this study we t...

Temporal changes in obstructive sleep apnea severity and body composition parameters during 6-month tofogliflozin administration in patients with heart failure and type 2 diabetes mellitus: a TOPARDS-HF substudy.

PURPOSE: Obstructive sleep apnea (OSA) is closely associated with obesity and fluid retention. Our previous study suggested that, in patients with heart failure, the sodium-glucose cotransporter 2 inh...

The Protective Effects of Chlorogenic Acid in Mitigating Gut-Brain Barrier Dysfunction and Autism-Like Symptoms Caused by Early-Life Stress in Mice: A Behavioral, Histopathological, and Molecular Study.

Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental condition shaped by both genetic predispositions and environmental influences. Early-life stresses (ELS), notably maternal separat...

Salidroside Alleviates Mobocertinib-Induced Cardiotoxicity by Improving Cardiac Electrophysiology.

Mobocertinib, a tyrosine kinase inhibitor approved for EGFR exon 20 insertion-mutated non-small cell lung cancer, induces cardiotoxicity manifesting as QT prolongation. Salidroside, a bioactive compou...

Association of the Mediterranean Diet, Physical Activity and Related Lifestyle Factors on the Mortality and Major Adverse Cardiovascular Events in Patients with Coronary Heart Disease: A Systematic Review and Meta-Analysis.

Introduction: Evidence linking Mediterranean dietary patterns and physical activity to mortality and major adverse cardiovascular events (MACEs) after coronary heart disease (CHD) diagnosis remains in...

Natural Products Targeting Myocardial Fibrosis: Pharmacological Basis, Molecular Mechanisms and Translational Barriers.

Myocardial fibrosis (MF) is a hallmark of pathological cardiac remodeling, driven by extracellular matrix (ECM) accumulation, fibroblast activation, and oxidative stress. Diverse natural products-nota...

Left Ventricular Longitudinal Strain Is Associated with Ascending Aortic Diameters in Healthy Adults-A Detailed Single-Center Retrospective Analysis from the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Healthy Study.

Background and Objectives: A more precise understanding of ventriculo-arterial coupling is essential, particularly regarding quantitative and qualitative associations can be demonstrated between the a...

Bibliometrics and Bioinformatics Exploration of Research Hotspots and Key Targets in Comorbidity: Interstitial Lung Disease and Pulmonary Hypertension.

Interstitial lung disease (ILD) and pulmonary hypertension (PH) frequently coexist as comorbidities, leading to poor clinical outcomes and limited therapeutic options. Identifying important research h...

Endoplasmic Reticulum Stress-Related Immune Signature in Atrial Fibrillation: Machine Learning and Single-Cell Transcriptomics.

This study describes a reproducible computational workflow for identifying endoplasmic reticulum stress (ERS)-related gene signatures in atrial fibrillation (AF) by integrating bulk transcriptomics, m...

Analysis of demographic and clinical characteristics of patients with chronic renal failure in Mosul City, Iraq.

AIM: To assess demographic and clinical determinants of CKD among patients undergoing haemodialysis in Mosul, Iraq. METHODS: A descriptive cross-sectional study was conducted at a public dialysis cent...

Analysis of the effects of heat-not-burn tobacco product use on cardiorespiratory symptoms in adults.

AIM: To determine if heat-not-burn (HNB) tobacco products are a safe alternative to cigarette smoking by inducing decreased decline of cardiorespiratory function. METHODS: A clinical observational, cr...

Subclinical systolic left ventricular dysfunction in patients with non-significant coronary artery stenosis detected by coronary computed tomography (CT) angiography.

AIM: To investigate the relationship between coronary artery calcium (CAC) score and left ventricular global longitudinal strain (LV GLS) in patients with arterial hypertension who had a negative trea...

False-negative 99mTc-PYP bone scintigraphy in early cardiac amyloidosis: a rapidly progressive case in a young woman.

Cardiac amyloidosis is one of the aetiologies of treatable heart failure. Cardiac amyloidosis is rare in young patients, but it can present atypically, leading to diagnostic delays. In this case, a 33...

A multidimensional item response theory analysis of the Seattle Angina Questionnaire: measurement precision, differential item functioning, and potential for item reduction.

PURPOSE: The Seattle Angina Questionnaire (SAQ) is widely used to measure disease-specific health status in coronary artery disease, but its psychometric properties have not been evaluated using multi...

Quantifying the impact of coronary-related experimental simplifications on flow features in native and neo-sinus following transcatheter aortic valve implantation.

Existing in vitro and numerical studies lack consensus regarding whether and how coronary arteries should be incorporated. This study aims to systematically investigate the effects of coronary artery ...

STOP-RIO study: protocol for a randomised, controlled, open-label non-inferiority trial to test the safety of discontinuation of riociguat after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension.

INTRODUCTION: Balloon pulmonary angioplasty (BPA) improves haemodynamics and outcomes in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Riociguat is frequently initiat...

Conversational artificial intelligence HeAlth supporT in Atrial Fibrillation Self-Management (CHAT-AF-S): rationale and randomised controlled trial design.

INTRODUCTION: Atrial fibrillation (AF), a common arrhythmia, is associated with impaired quality of life and increased stroke risk and mortality. Clinical guidelines recommend leveraging digital techn...