Development and Validation of a Nomogram for Estimating Stroke Risk in Nonvalvular Atrial Fibrillation Patients With Left Atrial Stiffness: A Single-Center Cross-Sectional Study.

BACKGROUND: Nonvalvular atrial fibrillation (NVAF) is a prevalent arrhythmia associated with an increased risk of ischemic stroke. This study is aimed at assessing the clinical significance of echocar...

Balancing Beats and Bleeding: The Evolving Landscape of Atrial Fibrillation and Anticoagulation in the Past Two Decades.

BackgroundAnticoagulation has been the cornerstone for stroke prevention in patients with atrial fibrillation (AF). This study aims to describe the research trends and research hotspots in anticoagula...

Single-point insulin sensitivity estimator and atrial fibrillation: association and incremental discriminative value in a hospital-based population.

BACKGROUND: The single-point insulin sensitivity estimator (SPISE), derived from triglycerides, high-density lipoprotein cholesterol, and body mass index, has emerged as an easily calculated marker of...

Diagnostic Accuracy of Anti-factor Xa Activity, PT, and APTT for Clinically Relevant Rivaroxaban Levels in Older AF Patients.

BackgroundRapid assessment of rivaroxaban exposure is clinically critical for older patients with atrial fibrillation in scenarios such as acute bleeding, urgent invasive procedures, or thrombolysis d...

An integrated multi-omics study of key mediators and therapeutic targets for doxorubicin-induced atrial fibrillation.

BACKGROUND: Doxorubicin (DOX), a widely used chemotherapeutic agent for cancer patients, is associated with a significant risk of inducing atrial fibrillation (AF), a serious cardiac complication that...

Salvianolic Acid B Alleviates Atrial Fibrillation-Associated Fibrosis With Modulation of COL1A2 and the PI3K-AKT Pathway.

BACKGROUND: Atrial fibrillation (AF), the most prevalent cardiac arrhythmia, is strongly associated with atrial fibrosis. Salvianolic acid B (Sal-B), a bioactive compound extracted from Salvia miltior...

Comparative Effectiveness and Safety of Interventions for Atrial Fibrillation in Heart Failure: A Network Meta-Analysis of Randomized Trials.

BACKGROUND: Patients with HF and AF face high risks of death and HF decompensation, yet the comparative effectiveness of commonly used AF management strategies remains uncertain. This study is aimed a...

Innovative Management of Rhythm Disorders in Adults with Congenital Heart Disease.

Adults with congenital heart disease (ACHD) represent a rapidly growing patient population that is uniquely predisposed to rhythm disturbances. Arrhythmia mechanisms are shaped by congenital anatomy, ...

Influence of symptom burden on physical activity among patients with atrial fibrillation: The chain-mediating roles of exercise sensitivity and kinesiophobia.

OBJECTIVE: Grounded in an integrated fear-avoidance and cognitive-behavioural framework, this study aimed to examine the independent and sequential mediating roles of exercise sensitivity and kinesiop...

Effects of cardiac rehabilitation on atrial fibrillation recurrence, mortality, hospitalization, and exercise capacity: a systematic review and meta-analysis.

BACKGROUND: Cardiac rehabilitation (CR) may benefit patients with atrial fibrillation (AF) in areas such as exercise capacity. However, evidence regarding its impact on AF recurrence, a key clinical o...

Association Between TNF-Alpha Levels and Atrial Fibrillation Outcomes: A Systematic Review and Meta-Analysis.

Background and objectivesPrevious studies suggest a link between tumor necrosis factor-alpha (TNF-alpha) levels and atrial fibrillation (AF). However, the nature of this relationship is disputed. To a...

Cardiac arrhythmias following COVID-19 vaccination: insights from the U.S. vaccine adverse event reporting system (VAERS), December 2020-January 2025, United States.

BACKGROUND: Although COVID-19 vaccines are highly effective in preventing infection and severe disease, their cardiovascular safety, particularly regarding arrhythmic risk, continues to raise concerns...

Multimodal Patient-Specific Identification of Atrial Flutter Circuits From ECG Time Series Using Explainable Machine Learning.

OBJECTIVE: Accurate pre-procedural identification of atrial flutter (AFL) mechanisms can streamline mapping and indirectly inform ablation strategy, yet surface-electrocardiogram (ECG) criteria remain...

SPISE Index (Single-Point Insulin Sensitivity Estimator): A Long-Term Predictor of Recurrence in Elderly Patients with Atrial Fibrillation After Radiofrequency Ablation.

BACKGROUND: Insulin resistance (IR) plays a significant role in the onset and progression of atrial fibrillation (AF). The single-point insulin sensitivity estimator (SPISE) index is a novel marker fo...

CHA(2)DS(2)-VASc and CHA(2)DS(2)-VA Scores as Predictors of Short- and Long-Term Mortality Following Transvenous Lead Extraction.

BACKGROUND: Multimorbidity significantly affects prognosis in patients after transvenous lead extraction (TLE). The CHA2DS2-VASc and CHA2DS2-VA scores, widely used for stroke risk stratification in at...

Association Between Sleep Disorders and Adverse Cardiovascular Outcomes in Patients with Chronic Obstructive Pulmonary Disease: Insights from the UK Biobank.

BACKGROUND AND OBJECTIVE: A potential association between sleep disturbances and adverse cardiovascular prognoses has been proposed in patients with chronic obstructive pulmonary disease (COPD), altho...

Assessing modifiable risk factors for atrial fibrillation/flutter in the young: a hybrid local-global study.

BACKGROUND: Atrial fibrillation (AF)/atrial flutter (AFL) are among the most prevalent cardiovascular diseases in the young. This study aimed to assess modifiable risk factors by integrating a global ...

Case Report: Two cases of PD-1 inhibitor-associated myocarditis with bidirectional ventricular tachycardia.

BACKGROUND: The clinical application of targeted anti-programmed cell death protein 1 (PD-1) therapy has significantly improved the prognosis of patients with various advanced malignancies. However, l...

Defective efferocytosis links autonomic dysfunction and atrial fibrillation: multi-omics integration and in vivo validation.

INTRODUCTION: Atrial fibrillation (AF) is the most common and clinically significant arrhythmia requiring treatment. Although an imbalance between the sympathetic and vagal branches of autonomic nervo...

Real-World Antithrombotic Management of Nonvalvular Atrial Fibrillation in Patients Undergoing Percutaneous Coronary Intervention in China: A Cross-Sectional Study.

Antithrombotic therapy in patients with nonvalvular atrial fibrillation (NVAF) undergoing percutaneous coronary intervention (PCI) is clinically challenging, with real-world strategies often remaining...