Lactate/AARS1-mediated H3K18la in the modulation of ACSL4 transcription to trigger ferroptosis in myocardial ischemia reperfusion.

OBJECTIVE: Hypertension serves as a pivotal risk factor for myocardial ischemia reperfusion injury (MIRI). Reciprocally, MIRI exacerbates hypertension by inducing oxidative stress, inflammatory respon...

Dnmt1 associated Gja1 promoter methylation changes are implicated in Cx43 remodeling during acute myocardial ischemia/reperfusion injury.

DNA methylation has traditionally been regarded as a stable epigenetic modification. However, emerging evidence indicates that oxidative and genotoxic stress can induce locus-specific methylation chan...

Environmental risk factors for false-positive results in newborn screening for primary carnitine deficiency: a multicenter large-scale retrospective cohort study.

OBJECTIVE: To identify environmental risk factors contributing to false-positive results in newborn screening for primary carnitine deficiency (PCD) and to evaluate their predictive performance. METHO...

Causal associations between antibody-mediated immune responses to infectious agents and cardiovascular inflammatory diseases: A Mendelian randomization study based on UK Biobank and FinnGen.

A two-sample Mendelian randomization study was performed to evaluate causal associations between 46 pathogen-specific antibodies and six cardiovascular inflammatory diseases: myocarditis, pericarditis...

A global model for symptomatic obstructive hypertrophic cardiomyopathy to assess the cost-effectiveness of mavacamten: results from a Dutch societal perspective.

OBJECTIVES: To explore the cost-effectiveness of mavacamten + beta-blocker/calcium channel blocker therapy (BB/CCB) versus BB/CCB monotherapy for the treatment of symptomatic obstructive hypertrophic ...

Real-world burden of hypertrophic cardiomyopathy on healthcare use and health-related quality of life in Italy, Spain, and the United States.

BACKGROUND AND AIMS: Hypertrophic cardiomyopathy (HCM) is a chronic, progressive, genetic heart disease characterized by hypercontractility and hypertrophy. As treatment options evolve, characterizing...

GSK-3β in myocardial ischemia-reperfusion injury: molecular insights and therapeutic approaches.

OBJECTIVES: To synthesize current evidence on the role of glycogen synthase kinase-3β (GSK-3β) in myocardial ischemia-reperfusion injury (MIRI) and evaluate its potential as a therapeutic target. METH...

Racial and Ethnic Disparities in Acute Myocarditis Outcomes in the United States.

BACKGROUND: Racial and ethnic disparities in cardiovascular outcomes are well established, but whether these inequities extend to acute myocarditis remains insufficiently characterized. HYPOTHESIS: Ra...

Severe Fetal Cardiomyopathy: Considerations for Extracorporeal Cardiopulmonary Resuscitation During Neonatal Resuscitation.

Primary cardiomyopathies are associated with poor neonatal outcomes, including high mortality rates. Neonatal care of infants with significant prenatal cardiac diagnoses may warrant additional managem...

First-Phase Ejection Fraction: A Novel Approach to Detecting Early Systolic Dysfunction in Hypertrophic Cardiomyopathy.

BACKGROUND: The assessment of stable coronary artery disease has been performed using the first-phase ejection fraction (EF1) in previous research. However, the use of EF1 has seldom been employed in ...

Neuropathy in Val122Ile Hereditary Transthyretin (ATTR) Amyloidosis: A Multicenter Retrospective Cohort Study.

BACKGROUND AND AIMS: The Val122Ile ATTR Amyloidosis has traditionally been linked to cardiac manifestations. Recent studies suggest that neuropathy may be relevant. In this study, we characterized its...

Neurological Adverse Events Associated With Immune Checkpoint Inhibitors Identified Through Disproportionality Analysis of the FDA Adverse Event Reporting System.

BACKGROUND: Neurological immune-related adverse events (N-irAEs) from immune checkpoint inhibitors (ICIs) are rare but potentially fatal. This study aimed to characterize their real-world profile to s...

[Care pathway for the diagnosis and management of patients with hypertrophic phenotype in the Marche Region: the experience of the Marche Cardiomyopathies Network].

BACKGROUND: The aim of this study was to describe the clinical care pathway and results of the first 6 years of activity of the Marche Cardiomyopathy Network (MCN) dedicated to cardiomyopathies with a...

Left Ventricular Global Longitudinal Strain as a Marker of Subclinical Myocardial Dysfunction in Youths With Type 1 Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis.

AIMS: To assess Left Ventricular Global Longitudinal Strain (LV GLS) in youths with type 1 diabetes mellitus (T1DM) compared with healthy controls, as a marker of subclinical myocardial dysfunction. M...

Genetically proxied circulating PD-1/PD-L1 levels and broadly defined myocarditis: A bidirectional Mendelian randomization study with exploratory lipidomic analyses.

Myocarditis is an inflammatory myocardial disease with potentially severe outcomes. Programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) regulate immune tolerance, but the asso...

Machine learning-based prediction model for predicting the impact of insulin resistance on the risk of ischemic cardiomyopathy.

BACKGROUND: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and triglyceride glucose-body mass (TyG-BMI) index are reliable indicators of insulin resistance (IR). This study ...

Role of bacterial pathogens and toxins in sepsis-related myocardial injury: a scoping review.

OBJECTIVES: To map and synthesise human and experimental literature examining associations between specific bacterial pathogens or toxins and myocardial injury in adult sepsis and to evaluate whether ...

Identification of Aging and Mitochondria-Related Hub Genes in Dilated Cardiomyopathy.

Dilated cardiomyopathy (DCM) is characterized by left ventricular dilation and systolic dysfunction and is associated with mitochondrial dysfunction and immune-inflammatory activation. However, aging-...

Longitudinal multimodal assessment of peripheral nerve involvement in wild-type transthyretin amyloidosis.

INTRODUCTION: Wild-type transthyretin amyloidosis (ATTRwt) is a progressive disease marked by extracellular transthyretin amyloid deposition, predominantly causing cardiomyopathy. Neurological manifes...

Efficacy and safety of glucagon-like peptide-1 receptor agonists for diabetic cardiomyopathy: a protocol for systematic review and meta-analysis.

INTRODUCTION: Diabetic cardiomyopathy (DCM) is an important contributor to heart failure and death in patients with diabetes. Current management strategies mainly focus on glycaemic control and sympto...