Trials and tribulations of spironolactone in heart failure with preserved ejection fraction: Insights from the SPIRIT-HF trial.

Heart failure with preserved ejection fraction represents a clinical challenge, accounting for at least 50% of heart failure (HF) cases globally, with a historical lack of efficacious and disease-modi...

Early urinary sodium vs B-type natriuretic peptide for predicting 30-day outcomes in acute decompensated heart failure: a prospective cohort study.

AIM: To compare the prognostic performance of early urinary sodium (UNa) and B-type natriuretic peptide (BNP) for predicting 30-day adverse outcomes in emergency department (ED) patients with acute de...

The social context and environment as targets for heart failure prevention.

The prevalence of heart failure (HF) continues to rise and disproportionately affects disadvantaged populations. This has created an urgent need to concurrently tackle HF prevention and therapeutics, ...

Cognitive assessment in heart failure: clinical value, timing, and practical tools.

This narrative review examines the clinical value of cognitive assessment in heart failure, highlighting optimal timing, practical tools, and the epidemiology, pathophysiology, and clinical implicatio...

Biological age acceleration and mortality risk among U.S. adults with cardio-kidney-metabolic syndrome, stages 0-3: An NHANES cohort study.

This study aims to evaluate the associations of Klemera-Doubal Method Biological Age Acceleration (KDM-BAA) and Phenotypic Age Acceleration (PAA) with all-cause and cause-specific mortality in U.S. ad...

Risk factors for sudden cardiac death in heart failure: A systematic review and meta-analysis of risk factors derived from prediction models.

BACKGROUND: Heart failure (HF) is a global health burden with high mortality. Sudden cardiac death (SCD) remains a major complication, highlighting the need for accurate risk prediction. METHODS: We c...

A case report of acute heart failure, pulmonary edema, and pleural effusion in an elderly patient with organic mental disorder: An integrative holistic nursing approach.

RATIONALE: Organic mental disorders complicate acute heart failure (AHF) in elderly patients, creating a heart-brain vicious cycle in which cognitive impairment masks cardiac symptoms while hypoxemia ...

Why guideline-directed medical therapy depends on more than guidelines: microeconomics of medication use in heart failure.

Despite substantial mortality benefits, fewer than 25% of individuals with heart failure with reduced ejection fraction (HFrEF) receive all four pillars of guideline-directed medical therapy (GDMT), w...

Opioid Use for Dyspnoea in Advanced Heart Failure.

PURPOSE OF REVIEW: This narrative review aims to provide an overview of the available evidence on opioid use for refractory dyspnoea in advanced heart failure, focusing on mechanisms, effectiveness, s...

SREBF2 promotes mitophagy and protects against ferroptosis via Cav-1-regulated PINK1/Parkin signaling in ischemic heart failure.

Myocardial infarction-induced heart failure (MI-HF) remains a major contributor to cardiovascular mortality, yet the molecular mechanisms underlying its progression, particularly those involving ferro...

Altered bone marrow niche forms central innate immune memory driving cardiac dysfunction.

We previously showed that heart failure induces innate immune memory in hematopoietic stem and progenitor cells, which contributes to recurrence of heart failure and impaired stress responses in multi...

Multimorbidity burden and hospitalisation outcomes in heart failure: a retrospective cohort study using Indonesian national health insurance claims data (2019-2024).

BACKGROUND: The expansion of universal health coverage (UHC) in many low- and middle-income countries (LMICs) has occurred alongside a growing burden of chronic disease and multimorbidity. Heart failu...

Hypoxia-Driven Mechanisms in Ischemic Heart Failure: A Bioinformatics, Machine Learning and Bayesian Network Study.

Hypoxia is a critical determinant in the etiology and progression of ischemic heart failure, but its underlying molecular mechanisms and regulatory interactions remain largely enigmatic. in our study,...

The long road to recognition: a historical review of amyloidosis from early pathology to disease-modifying therapy.

Within the last several decades, great strides are being made in both the diagnosis and treatment of cardiac amyloidosis, yet the condition itself has been a severely under-recognized cause of heart f...

[Development of a prediction model for acute heart failure based on B-type natriuretic peptide and multiple clinical indicators in acute dyspnea patients with varying renal function levels].

Objective: To investigate the diagnostic value of B-type natriuretic peptide (BNP) for acute heart failure (AHF) in acute dyspnea patients with different renal function statuses and to develop a diagn...

Patients' experiences of mobile health tools for chronic heart failure self-management: a qualitative meta-synthesis.

OBJECTIVE: To systematically synthesise qualitative evidence on the experiences of chronic heart failure (CHF) patients using mobile health (mHealth) tools for self-management and to identify factors ...

Managing Cardiogenic Shock in the Era of Multimodal Mechanical Support: Bridging to Transplant or Recovery.

PURPOSE OF REVIEW: To review the contemporary management of cardiogenic shock in the era of multimodal temporary mechanical circulatory support, with emphasis on phenotype-guided device selection, ser...

Racial and Ethnic Differences in Dietary Intake and Metabolic Profiles Among Adults with Heart Failure, Type 2 Diabetes, and Overweight or Obesity: A Secondary Analysis of the Pro-HEART Trial.

Background: Racial and ethnic disparities in heart failure (HF) outcomes are well documented, but little is known about dietary intake and metabolic profiles among individuals with chronic HF and over...

The Clinical Value of NT-proBNP, sST2, and Galectin-3 in the Management of Heart Failure: From Diagnosis to Dynamic Monitoring: A Narrative Review.

Heart failure management remains a critical clinical challenge. While modern neurohormonal therapies have significantly improved survival, standard clinical assessments often fail to capture the full ...

Diabetes-Associated Heart Failure After Percutaneous Coronary Intervention: Molecular Mechanisms and Prospects for Early Multi-Targeted Intervention.

Diabetes mellitus (DM) is a major independent risk factor for heart failure (HF) following percutaneous coronary intervention (PCI). Metabolic disturbances associated with DM, including insulin resist...