Rethinking Congestion in Heart Failure from Volume Overload to Venous Pressure and Organ Disfunction with VExUS.
Congestion is a major driver of symptoms, hospitalization, and adverse outcomes in heart failure (HF), yet its clinical assessment remains challenging. Traditional approaches based on physical examina...
Hypertensive Heart Failure with Preserved Ejection Fraction: Guidelines vs. Randomized Controlled Trials Evidence Gaps.
Hypertension is among the most important modifiable risk factors associated with heart failure with preserved ejection fraction (HFpEF) development and progression, yet guideline-directed blood pressu...
Empagliflozin Protects Against Doxorubicin Cardiotoxicity: Integrative Assessment of Cardiac Kinetics and Electrophysiology Using Machine Learning in a Rat Model.
Background/Objectives: Anthracycline-induced cardiotoxicity remains a major challenge in cancer treatment, and researchers are showing interest in artificial intelligence (AI) to improve the predictio...
Avoidance of Major Amputation After Deep Vein Arterialization and Advanced Wound Management in a Patient with Diabetes and No Direct Revascularization Options: A Case Report.
Chronic limb-threatening ischemia (CLTI) in patients with no conventional targets for revascularization presents a formidable challenge in limb salvage. Deep venous arterialization (DVA) is an emergin...
Circulating β-Hydroxybutyrate in Glycemic Progression and Diabetic Cardiomyopathy: Adaptive Signal or Maladaptive Substrate?
Circulating ketone bodies (KBs), particularly β-hydroxybutyrate (β-HB), have emerged as metabolites with dual roles as both oxidative fuels and metabolic signaling molecules. Beyond serving as an alte...
Enhanced Discrimination of Coronary Artery Disease Severity by Circulating Phoenixin-14: Evidence from a Clinical Laboratory Study.
Early identification of anatomically significant coronary artery disease (CAD) remains a major clinical challenge despite advances in cardiovascular diagnostics. Novel circulating biomarkers may impro...
Exploratory LC-MS/MS-Based Proteomic and Lipidomic Profiling of Plasma Samples from Premature Coronary Artery Disease Patients: A Pilot Study in a South Asian Population.
Premature coronary artery disease (PCAD) is a growing public health concern, especially in South Asia, where traditional risk factors fail to fully explain the increasing incidence of early-onset myoc...
Coronary Artery Vasospasm: Cellular and Molecular Insights.
Coronary artery vasospasm (CAV) is a transient, reversible constriction of the epicardial coronary arteries that reduces coronary blood flow and may cause myocardial ischemia. Despite its clinical sig...
Contributions of preeclampsia to preterm delivery: a hypothetical interventional cohort study using incremental propensity scores.
BACKGROUND: Preeclampsia remains a leading cause of preterm delivery (PTD). Conventional average causal effect estimands may not always be perfectly suited for assessing preeclampsia's contributions b...
Identification of the Mitochondrial Gene NME6 as an Immune Modulator in Heart Failure.
BACKGROUND: Heart failure (HF) is characterized by mitochondrial dysfunction and immune dysregulation. However, the underlying molecular mechanisms remain unclear. Functional enrichment analyses study...
SPI1 Promotes Intracranial Aneurysm Formation by Inhibiting Wnt5a Transcription.
BACKGROUND: SPI1 is a hub gene associated with intracranial aneurysms (IA) and is highly expressed in IA tissues. However, its functional role in IA formation remains unclear. This study aimed to inve...
Impact of superior mesenteric artery (SMA) adherent tissue in the context of pancreatic head resections- an observational study.
BACKGROUND: Resection of the periadventitial neurolymphatic tissue around the superior mesenteric artery (SMA) is considered a crucial component of oncologically complete resection in pancreatic head ...
Acute and Chronic Myocarditis in Men and Women.
PURPOSE OF REVIEW: Acute myocarditis (AM) shows sex-specific differences in prevalence, clinical phenotype, and outcomes. This review summarizes evidence from studies published between 2000 and 2026 r...
Threonine in Coronary Artery Disease: Insights From Metabolic Syndrome Amino Acid Profiling.
BACKGROUND Metabolic syndrome (MeS) amplifies cardiovascular risk, but molecular markers that distinguish between MeS and coronary artery disease (CAD) remain limited. The aim of this study was to det...
Cross-domain transfer learning strategy enhances interpretability of deep learning model explanations.
Clinical decision-making increasingly relies on deep neural networks (DNNs), yet their deployment in practice requires transparent and interpretable predictions. Explainable artificial intelligence (x...
Arrhythmic risk stratification in psoriatic arthritis: a retrospective, electrogram-based comparative analysis.
BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory systemic disease that is associated with cardiovascular comorbidities, particularly with an increased risk of arrhythmias. Despite the e...
Morphological and functional evaluation of the left ventricle in severe aortic stenosis with afterload mismatch: a South African single-centre, cross-sectional cardiovascular MRI-based study.
OBJECTIVES: This study aimed to investigate the relationship between left ventricular (LV) remodelling and systolic function in high-gradient severe aortic stenosis (AS) using cardiovascular magnetic ...
Postoperative Physiologic Comfort Management for Patients With Hepatocellular Carcinoma Undergoing Hepatic Arterial Infusion Chemotherapy.
PROBLEM IDENTIFICATION: Postoperative comfort management for patients with hepatocellular carcinoma undergoing hepatic arterial infusion chemotherapy remains unstandardized, with fragmented evidence l...
Age at menarche and adverse pregnancy and perinatal outcomes: triangulating evidence from multivariable and Mendelian randomization analyses.
BACKGROUND: Observational studies have suggested that a younger age at menarche is associated with increased risks of adverse pregnancy and perinatal outcomes. However, it is unclear whether these rel...
Immunometabolic Remodeling in Ischemic and Non-Ischemic Heart Failure.
Heart failure (HF) is traditionally classified by etiology or ejection fraction, but these categories do not fully explain the mechanisms driving disease progression. Increasing evidence suggests that...