Rethinking rate-related myocardial injury in sepsis: atrial fibrillation, heart rate, cardiac troponin T and long-term mortality.

BACKGROUND: Atrial fibrillation (AF), elevated heart rate and elevated high-sensitivity cardiac troponin T (hs-cTnT) are common in sepsis, but their independent and combined prognostic significance re...

The endothelial activation and stress index (EASIX) predicts hazards of short- and long-term mortality in acute ischemic stroke: a retrospective cohort study.

INTRODUCTION: Endothelial activation and stress index (EASIX) is a biomarker of endothelial dysfunction and has been validated previously as a prognostic score for mortality in various diseases, inclu...

SECmeres outperform extracellular vesicles as potential blood RNA biomarkers for Alzheimer's disease.

Cells release heterogeneous extracellular vesicles and particles (EVPs) into circulation, carrying RNA and proteins that reflect their origin. Recently, brain-derived EVs have gained significant atten...

Modification of Calcified Native and Surgical Bioprosthetic Aortic Valves: Lessons From the Bench.

BACKGROUND: Leaflet modification (LM) techniques, including electrosurgical and mechanical BASILICA (bioprosthetic or native aortic scallop intentional laceration to prevent iatrogenic coronary artery...

Balloon-Assisted Translocation of the Mitral Anterior Leaflet to Prevent Outflow Tract Obstruction During TMVR: The BATMAN Registry.

BACKGROUND: BATMAN (balloon-assisted translocation of the mitral anterior leaflet) is an increasingly adopted technique to modify the anterior mitral leaflet (AML) and prevent left ventricular outflow...

The ELASTA-T Technique for TTVR After Failed T-TEER: An Operator-Oriented Guide to Planning, Execution, Pitfalls.

Failure of tricuspid transcatheter edge-to-edge repair (T-TEER) with persistent severe tricuspid regurgitation (TR) is an increasingly encountered clinical scenario in contemporary structural heart di...

Leaflet Modification Technique With UNICORN in Failed Aortic Bioprosthesis: Procedural Step-by-Step, Best Practice, and Troubleshooting.

The UNICORN (undermining iatrogenic coronary obstruction with radiofrequency needle) technique was developed in 2022 to reduce the risk for coronary obstruction during valve-in-valve transcatheter aor...

Mitral Valve Leaflet Modification: A Working Group Position Statement on Best Practices and Step-by-Step Guide.

Left ventricular outflow tract (LVOT) obstruction is a potentially lethal complication of transcatheter mitral valve replacement (TMVR). The risk for LVOT obstruction can reliably be identified on pre...

Equitable lipid optimisation through a data-driven, pharmacist-led secondary prevention pathway.

BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality in the UK, with raised cholesterol contributing to 25%-28% of ASCVD deaths. Despite well-establ...

Leaflet Modification to Mitigate Coronary Obstruction Risk During TAVR: Results From the LOFTER-TAVR Registry.

BACKGROUND: Coronary obstruction (CO) is a rare but life-threatening complication of transcatheter aortic valve replacement (TAVR). Leaflet modification techniques have been developed to mitigate this...

Standardised, telemonitored titration of guideline-directed medical therapy in heart failure is associated with faster optimisation and improved persistence compared to standard of care.

BACKGROUND: Rapid initiation and up-titration of guideline-directed medical therapy (GDMT) are critical for improving outcomes in heart failure with reduced ejection fraction (HFrEF), yet initiation i...

Association of ischaemic stroke/TIA with subsequent oral anticoagulant adherence in patients with atrial fibrillation: a scoping review.

OBJECTIVES: This study aimed to investigate the association and potential causal relationship between ischaemic stroke/transient ischaemic attack (TIA) and oral anticoagulant (OAC) adherence using Bra...

Is endothelial dysfunction induced by aromatase inhibitors reversible after treatment?

PURPOSE: Aromatase inhibitors (AIs) are standard therapy for postmenopausal women with hormone receptor-positive breast cancer. However, prolonged AI use is associated with increased cardiovascular (C...

Association of ultra-processed foods (UPFs) with hypertriglyceridemic waist (HTGW) phenotype, oxidative stress, and inflammation in Iranian adults: a cross-sectional study.

In this study, we evaluated the association between UPFs with HTGW in relation to oxidative stress and inflammation in Iranian adults, as no previous study had assessed these altogether. This cross-se...

Left Ventricular Thrombus in Ischemic Heart Failure: Machine-learning-based Prediction of Six-month Persistence and One-year Outcomes.

Left ventricular thrombus (LVT) in ischemic heart failure carries embolic risk; tools to anticipate persistence are limited. We studied 190 consecutive patients with imaging-confirmed LVT managed with...

Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia.

High levels of low-density lipoprotein cholesterol (LDL-c) have been recognized as the main causal factor of atherosclerotic cardiovascular disease (ASCVD) and are influenced by both genetic and envir...

Vitamin D Status and Atherogenic Lipid Profiles, Including Lipoprotein(a), in Elite Athletes.

Background/Objectives: Vitamin D has been implicated in lipid metabolism, but data regarding its association with atherogenic lipoproteins in elite athletes remain limited. Elite athletes represent a ...

Super-Resolution 3D Imaging Reveals Disarray of Dyadic Calcium Ion Channels in Failing Hearts Expressing Low Thyroid Hormone Function.

Ventricular remodeling occurring in heart failure (HF) involves structural disarray of the sarcolemma T-tubule (TT)-sarcoplasmic reticulum (SR) dyad junctions, thereby disrupting the close apposition ...

Joint Impact of Triglyceride-glucose Index and Free Fatty Acid Levels on Cardiovascular Outcomes in Overweight or Obese Patients with Coronary Artery Disease - A Large Multicenter Prospective Study.

OBJECTIVE: To investigate the joint effect of free fatty acid (FFA) and the triglyceride-glucose (TyG) index on the prognosis of overweight and obese coronary artery disease (CAD) patients. METHODS: A...

[Study on preoperative prediction of microvascular invasion based on contrast-enhanced ultrasound habitat imaging combined with peritumoral radiomics in hepatocellular carcinoma].

Objective: Hepatocellular carcinoma has a poor prognosis, and microvascular invasion (MVI) is an important indicator for guiding surgical decisions and influencing long-term survival. This study aims ...