Electrical storm after percutaneous coronary intervention for subacute anterior myocardial infarction with heart failure, treated with multidisciplinary therapy.
Electrical storm (ES) following acute coronary syndrome is rare but often fatal. A man in his early 70s experienced syncope and dyspnoea while playing golf, approximately 2 weeks after experiencing ba...
Screening for candidate genes and cell populations associated with atherosclerotic calcification using single-cell RNA sequencing.
Calcification often occurs as a characteristic pathological manifestation in the progression of atherosclerosis (AS) plaques, but its mechanism is not fully understood yet. The purpose of this researc...
Complete versus incomplete coronary revascularisation in patients undergoing PCI after TAVI.
BACKGROUND: The optimal revascularisation strategy for patients undergoing percutaneous coronary intervention (PCI) after transcatheter aortic valve implantation (TAVI) remains undefined. In particula...
Impact of a durable left ventricular assist device on inflammation and cardiac remodelling in subjects with advanced heart failure.
BACKGROUND: This study aimed to explore the association of long-term left ventricular assist device (LVAD) support with changes in inflammation and cardiac remodelling in subjects with advanced heart ...
In-hospital cardiopulmonary resuscitation with balloon occlusion of the descending aorta: protocol of the randomised controlled CPReboa study.
INTRODUCTION: Cardiac arrest (CA) remains a major health burden with poor survival and poor neurological outcomes despite decades of advances in resuscitation science. Although high-quality cardiopulm...
Adenosine Triphosphate Nanoparticles with Blood-Brain Barrier Permeability for Prevention of Cerebral Ischemic Injury via Mitochondrial Homeostasis.
Cerebral ischemia induces selective neuronal death, largely due to mitochondrial dysfunction and ATP depletion. This energy crisis impairs mitophagy, exacerbates oxidative stress, and accelerates neur...
From Exposome-Scale Screening to Foam Cell Formation: Identifying Environmental Chemicals with Atherogenic Potential via Nuclear Receptor Perturbation.
Cardiovascular diseases driven by atherosclerosis are a leading global cause of mortality. However, currently identified risk chemicals account for only a small fraction of the environmental chemical ...
Astrocyte-Microglia Crosstalk in Post-Hemorrhagic Neurovascular Microenvironment: Mechanistic Nodes, Cross-Stroke Comparisons, and Therapeutic Reprogramming.
BACKGROUND: Intracerebral hemorrhage (ICH) produces a rapidly evolving and spatially heterogeneous neurovascular microenvironment in which secondary injury is shaped not only by hematoma volume and lo...
BHT and Its Metabolites Disrupt β2-Adrenergic Signaling: A Biotransformation-Dependent Cardiotoxicity Mechanism in Zebrafish.
Butylated hydroxytoluene (BHT) is a widely used synthetic phenolic antioxidant, ubiquitously detected in aquatic environments. While traditionally considered safe based on in vitro data, BHT adversely...
Celiac Disease and the Nervous System: A Comprehensive Overview of Neurological Manifestations and Underlying Mechanisms.
Celiac disease (CD) is a chronic immune-mediated enteropathy triggered by gluten ingestion in genetically susceptible individuals. While traditionally associated with gastrointestinal (GI) symptoms, C...
Umbilical venous catheter tip position and risk of portal vein thrombosis in neonates: a retrospective cohort study.
PURPOSE: Umbilical vein catheterization (UVC) is widely used for vascular access in sick, especially preterm neonates. However, UVC placement is associated with an increased risk of portal vein thromb...
Practice nurse management of hypertension in primary care: a scoping review.
AIM: To review the current diagnosis and treatment of hypertension (HTN) and explore alternative care management options. BACKGROUND: HTN is underdiagnosed and poorly managed in the UK. With an increa...
A reference protein atlas of the adult mouse brain vasculature.
Current methods for assessing low-abundance proteins in individual cells are limited. As a result, cell functions are often inferred from single-cell RNA sequencing (scRNA-seq) data, which can be misl...
Visit-to-Visit Blood Pressure Variability and Cerebral White Matter Lesion Progression: A Pooled Individual Patient Data Analysis of 2 Trials.
BACKGROUND AND OBJECTIVES: Visit-to-visit blood pressure variability (BPV) may contribute to cerebral white matter lesions (WML) progression, but previous evidence has been inconsistent and limited by...
Ultra-Processed Food-Rich Dietary Proxies, Dietary-Pattern Context, and Cardiometabolic Outcomes in Spain: Weighted Evidence Consistent with Age Confounding and Possible Reverse-Causality Bias from the 2023 Spanish Health Survey.
BACKGROUND/OBJECTIVES: Ultra-processed foods (UPFs) are linked to cardiometabolic disease, but cross-sectional surveys often underestimate or invert these associations due to age structure, diagnosis-...
From aging biology to cardiac biotechnology: emerging platforms for modeling cardiac aging.
Aging is a major contributor to cardiovascular disease and mortality in older adults. Yet most preclinical and experimental cardiac studies fail to account for age as a primary biological variable, le...
Validation of Self-Reported Disease History in Korea: A National Health Insurance Cohort Study.
BACKGROUND: Self-reported disease history is widely used in epidemiological studies but is susceptible to misclassification. This study aimed to evaluate the accuracy of self-reported history of hyper...
Berlin heart EXCOR® implantation for Fontan failure in right-sided heterotaxy with ventricular septal protuberance: autopsy case report.
A 4-year-old boy with a diagnosis of right-sided heterotaxy syndrome was transferred to our hospital under the extracorporeal membrane oxygenation (ECMO). He had undergone an extracardiac total cavopu...
Noninvasive assessment of fetal metabolic acidemia by automated analysis of cardiac function using color tissue Doppler imaging in a sheep model.
Reliable noninvasive methods for accurately diagnosing fetal metabolic acidemia are still lacking. Our aim was to evaluate an ultrasound-based noninvasive method for assessing metabolic acidemia by an...
Common genetic variants in dyslipidemia, inflammation, and angiogenesis pathways associated with diabetic nephropathy in Tunisians.
INTRODUCTION: Dyslipidemia, inflammation and angiogenesis pathways contribute to the genetic susceptibility to diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). This study investigated the...