SEM1 Downregulates HSPA8 to Suppress TLR4/MyD88/NF-κB Signaling and Alleviate Myocardial I/R Injury.
Inflammation plays a pivotal role in the pathogenesis of myocardial ischemia/reperfusion (I/R) injury, highlighting inflammation suppression as a critical therapeutic strategy. The inflammatory respon...
Impact of Obstructive Sleep Apnea on Blood-Brain Barrier Permeability and Membrane Proteins.
The blood-brain barrier (BBB) carefully regulates the transport of molecules between the blood and the nervous tissue. Obstructive sleep apnea (OSA) is a chronic condition that induces structural and ...
Glycyrrhizic Acid Alleviates Atherosclerosis in ApoE(-/-) Mice via Microbial Indole-3-Lactic Acid-Mediated AhR-p65 Interaction in the Endothelium.
Glycyrrhizic acid (GL), a natural triterpenoid glycoside extracted from the "medicine food homology" herb Glycyrrhiza glabra L., exhibits potent anti-atherosclerotic effects; yet its underlying mechan...
Support needs for chronic disease self-management among persons attending a Primary Health Care facility in Victor Khanye, Mpumalanga.
BACKGROUND: With the increasing burden of non-communicable chronic diseases, it is important to empower people to self-manage their conditions. This study aimed to explore the support that persons li...
Region- and Cell-Specific Vulnerability to ROS After Global Brain Ischemia-Reperfusion Injury: Molecular and Cellular Mechanisms.
Global brain ischemia-reperfusion (I/R) injury manifests as selective neuronal vulnerability rather than uniform tissue damage. Specific neuroanatomical regions-most notably the hippocampal cornu ammo...
Trends and Outcomes of Antithrombotic Strategies for Valve-in-Valve TAVR: The STS/ACC TVT Registry.
BACKGROUND: The optimal antithrombotic strategy after valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) for degenerated aortic bioprostheses remains undetermined, and current practice...
BMI-based prediction models for short-term and long-term mortality following coronary artery bypass grafting using the MIMIC-IV database: a retrospective cohort study.
OBJECTIVE: This study aims to evaluate the relationship between obesity (measured by Body Mass Index (BMI)) and postoperative mortality in patients undergoing coronary artery bypass grafting (CABG) an...
Timing of Bleeding and Ischemic Events in High-Bleeding Risk Patients Treated With 1-Month DAPT.
BACKGROUND: Understanding the concomitant evolution of bleeding vs ischemic risk after percutaneous coronary intervention (PCI) in patients at high bleeding risk (HBR) treated with 1-month dual antipl...
Drug-Coated Balloon-Based Angioplasty for Chronic Total Occlusions: The PICCOLETO X Study.
BACKGROUND: Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) often requires extensive metal implantation, which may impair vascular vasomotor function and increase the risk for l...
Investigation and management of breakthrough ischemic stroke in anticoagulated patients with atrial fibrillation.
Ischemic stroke is a serious complication of atrial fibrillation that is associated with substantial morbidity and mortality. For patients with non-valvular atrial fibrillation, treatment with a direc...
Validity, reliability and clinical utility of the Glittre ADL test in patients with atrial fibrillation.
Macrophage adenylyl cyclase 7 protects against myocardial ischemia/reperfusion injury in male mice.
Myocardial ischemia/reperfusion (I/R) injury undermines the clinical benefit of percutaneous coronary intervention, with cardiac macrophages playing critical roles. Here, using spatial transcriptomics...
Retrograde CTO PCI via Epicardial Collaterals: Techniques, Tools, and Risk Mitigation.
The retrograde approach to percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) is a technically demanding strategy that requires specialized expertise and knowledge. Septal co...
A Multidomain Lifestyle Intervention for Invasively Confirmed ANOCA: The SAMCRO Randomized Trial.
BACKGROUND: Angina with no obstructive coronary artery disease (ANOCA) is associated with persistent symptoms and impaired quality of life. Although guidelines advocate a patient-centered, multidiscip...
Impact of Aortic Annulus Size on Outcomes After Aortic Valve Replacement: The PARTNER 3 Trial.
BACKGROUND: There are limited studies comparing the impact of transcatheter aortic valve replacement (TAVR) vs surgical aortic valve replacement (SAVR) by annular size. OBJECTIVES: The aim of this pos...
SGLT2 Inhibitor on Infarct Size and LV Remodeling by CMR in Patients With AMI.
BACKGROUND: Although recent large-scale randomized trials have demonstrated that sodium-glucose cotransporter 2 (SGLT2) inhibitors following acute myocardial infarction (AMI) are safe, the mechanisms ...
Clarifying the Association Between Food Insecurity and Chronic Disease: Why Methods Matter.
PURPOSE OF REVIEW: Food insecurity (FIS), limited or uncertain access to adequate, nutritious food, is frequently cited as associated with various chronic health conditions. With the goal of determini...
Molecular biology of vascular bioenergetics rewiring: Mitochondrial protective mechanisms of Piper retrofractum in hypertension and oxidative injury.
Hypertension is a major contributor to cardiovascular morbidity and mortality, largely driven by oxidative stress, mitochondrial dysfunction, endothelial injury, and chronic vascular inflammation. Eme...
Association Between Inflammatory Biomarkers And Carotid Ultrasound Parameters In The Northern Manhattan Stroke Study.
Inflammation contributes to atherosclerosis and vascular remodeling, but the immune pathways associated with distinct carotid ultrasound phenotypes, including carotid intima-media thickness (cIMT), ma...
Paeoniflorin attenuates cardiac remodeling by targeting AKT1 and suppressing the AKT/NF-κB inflammatory axis.
BACKGROUND: Cardiac remodeling induced by continuous pressure overload exacerbates heart failure (HF), yet effective treatments remain limited. This study investigates the therapeutic efficacy and und...