MCL1 Promotes Endothelial Senescence and Atherosclerosis via Glycolytic Reprogramming-Induced H4K12 Lactylation.

Accumulation of senescent endothelial cells (ECs) accelerates atherosclerosis, yet the molecular orchestrators linking metabolic dysregulation to epigenetic reprogramming during EC senescence remain e...

Gaseous Air Pollutant Exposure and Atherosclerosis: A Systematic Study Integrating Multi-Omics and Network Toxicology.

Gaseous air pollution is a major environmental risk factor for atherosclerosis, yet the specific molecular networks linking Gaseous air pollution to atherosclerosis are not fully characterized. This s...

See the (In)Visible: Infrared Thermography for Characterizing Thermal Patterns Associated with Peripheral Arterial Disease and Diabetes Mellitus.

Background/Objectives: Peripheral arterial disease (PAD) and diabetes mellitus (DM) may produce different and overlapping plantar thermal patterns. This study descriptively characterized whole-foot te...

Targeting the Notch Signaling Pathway to Treat Atherosclerosis.

Atherosclerosis remains the principal underlying cause of myocardial infarction, ischemic stroke and peripheral artery disease, and its progression reflects a complex interplay between lipid accumulat...

Spatial decoupling of plaque and circulating immune programs defines a robust gene signature in atherosclerosis: A multi-cohort integrative analysis.

Atherosclerosis (AS) is driven by chronic vascular inflammation, yet the relationship between immune activity within atherosclerotic lesions and systemic immune signals in peripheral blood remains poo...

HSP27 regulates force-coordinated DDR1 condensate disassembly and liquid-to-gel phase transition.

Endothelial cell (EC) mechanosensing is essential for vascular homeostasis and atherosclerosis development, though the influence of blood flow patterns on EC signaling is not fully understood. Discoid...

The SMART-Youth study: protocol for a longitudinal prospective cohort study to identify disease-associated and lifestyle-associated cardiovascular risk factors for preclinical atherosclerosis in children with a chronic condition.

INTRODUCTION: Cardiovascular risk assessment and management in the paediatric population is a relatively uncharted territory. However, atherogenesis starts during childhood, making childhood and adole...

Novel Lipoprotein (a) Therapies: A Comprehensive Review.

PURPOSE OF REVIEW: Lipoprotein(a) [Lp(a)] is a genetically determined, independent risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. Plasma Lp(a) levels are 70...

INO80E Suppresses Oxidized LDL-Induced Endothelial Apoptosis Through HDAC1-Mediated Stabilization of YY1.

OBJECTIVES: Endothelial apoptosis is a central event in atherosclerotic vascular injury, yet the contribution of the INO80 chromatin-remodeling subunit INO80E to this process remains unclear. This stu...

Macrophage-Targeted ROS-Responsive Nanoplatform for Coordinated NF-κB and Nrf2 Modulation in Atherosclerosis Therapy.

Atherosclerosis (AS) is a progressive cardiovascular disease characterized by arterial plaque formation, macrophage-driven inflammation, and excessive accumulation of reactive oxygen species (ROS). Ho...

Adolescent intelligence and imaging-detected atherosclerosis in middle age: a population study of Swedish men.

BACKGROUND: Childhood or adolescent intelligence has been linked to major somatic diseases and premature mortality, but the underlying pathways remain unclear. The aim of this study was therefore to d...

Screening for candidate genes and cell populations associated with atherosclerotic calcification using single-cell RNA sequencing.

Calcification often occurs as a characteristic pathological manifestation in the progression of atherosclerosis (AS) plaques, but its mechanism is not fully understood yet. The purpose of this researc...

From Exposome-Scale Screening to Foam Cell Formation: Identifying Environmental Chemicals with Atherogenic Potential via Nuclear Receptor Perturbation.

Cardiovascular diseases driven by atherosclerosis are a leading global cause of mortality. However, currently identified risk chemicals account for only a small fraction of the environmental chemical ...

Guanxinshu attenuates atherosclerosis by suppressing Galectin-3-mediated NLRP3 inflammasome activation.

Atherosclerosis (AS) is a chronic inflammatory vascular disease strongly associated with the activation of the NLRP3 inflammasome. Studies have shown that Galectin-3 (Gal-3) promotes NOD-like receptor...

Association of the atherogenic index of plasma and derived indicators with future risk of liver diseases and alcoholic liver disease among Chinese middle-aged and elderly adults: A nationwide cohort study.

The precise association between the atherogenic index of plasma (AIP) and its derived anthropometric indicators and the future risk of liver diseases and alcoholic liver disease among Chinese middle-a...

Association between hearing loss, tinnitus, and atherosclerotic cardiovascular disease among American adults: A cross-sectional study.

The interconnections between hearing loss, tinnitus, and atherosclerotic cardiovascular disease (ASCVD) remain incompletely elucidated. This study sought to investigate the associations of ASCVD preva...

Tirzepatide and the risk of atherosclerotic cardiovascular events: population based cohort study.

OBJECTIVE: To estimate the magnitude of reduction in major adverse cardiovascular events (MACE) that would be observed in clinical practice from adding tirzepatide to standard of care treatment. DESIG...

Common Molecular Mechanisms and Candidate Drug Targets in Type 2 Diabetes Mellitus and Atherosclerotic Cardiovascular Disease.

This study examined the mechanisms underlying the comorbidity between type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD), while identifying potential therapeutic target...

Role of Lipin-1 in Macrophage-Mediated Atherosclerosis: Is It Atherogenic or Atheroprotective?

Macrophages are central regulators of atherosclerosis, governing lipid accumulation, inflammatory signaling, and plaque stability. Lipin-1 is a multifunctional lipid-metabolic regulator that integrate...

Comprehensive Evaluation of Atherosclerotic Cardiovascular Disease Risk Predictors Across the Pooled Cohort Equations, Predicting Risk of Cardiovascular Disease Events, and an Expanded Model.

BACKGROUND: Ten-year atherosclerotic cardiovascular disease (ASCVD) risk prediction models include the pooled cohort equations (PCE) and the Predicting Risk of Cardiovascular Disease Events (PREVENT) ...