Sex Differences in Outcomes by Revascularization Strategy in Patients With Femoropopliteal Peripheral Arterial Disease: A Substudy of the REVIVE Pooled Analysis.

BACKGROUND: Women have been underrepresented in peripheral artery disease revascularization trials. We aimed to analyze sex-specific outcomes after endovascular therapy (EVT) with stent implantation v...

Wall-Specific V-Flow Hemodynamics in Lower-Limb Peripheral Artery Disease: Diagnostic Nomogram and Periplaque Mapping.

BACKGROUND: Lower limb peripheral artery disease (PAD) involves localized atherosclerosis with disturbed hemodynamics. V-flow imaging is a vector Doppler technique enabling real-time assessment of wal...

Smoking Behavior and Major Cardiovascular and Limb Events in Patients With Peripheral Artery Disease.

IMPORTANCE: Smoking is the strongest modifiable risk factor for peripheral arterial disease (PAD), yet evidence on how postdiagnosis smoking behavior changes affect clinical outcomes remains limited. ...

[Elderly patients with chronic limb-threatening ischemia: conservative treatment is appropriate care within an evolving healthcare landscape].

Revascularization remains the cornerstone of treatment for CLTI. Conservative treatment represents an underexposed yet potentially appropriate alternative for selected elderly and frail patients. This...

Cost-Effectiveness of Endovascular vs Open Surgery for Chronic Limb-Threatening Ischemia.

IMPORTANCE: Choosing between endovascular and open (bypass) surgical revascularization for chronic limb-threatening ischemia has major implications for clinical practice. OBJECTIVE: To evaluate the co...

Identification of Hub Gene Characteristics and Immune Landscapes Across Aging Subtypes in Atherosclerosis: A Machine Learning-Based Multi-Omics Study With Experimental Verification.

Aging is a major risk factor for atherosclerosis (AS), but the aging-associated molecular characteristics and immune heterogeneity of AS remain incompletely understood. This study aimed to identify ag...

Human Myeloid-Derived Growth Factor Induces a Pro-Angiogenic Response and Functional Recovery in a Mouse Model of Peripheral Artery Disease.

Myeloid-derived growth factor (MYDGF) is a monocyte- and macrophage-secreted protein with anti-apoptotic and pro-angiogenic properties that has demonstrated protective effects in models of myocardial ...

Daidzein Mitigates Nicotine-Induced Atherogenesis via Nrf2/ROS/TXNIP-Dependent Inhibition of Macrophage Pyroptosis and Lipid Accumulation.

Food-derived bioactive components play a crucial role in the prevention of cardiovascular diseases. Daidzein (DAI), a soy isoflavone, possesses notable cardioprotective potential; however, its precise...

Atherogenic Burden and Remnant Cholesterol Associate With Electrophysiological Severity in Carpal Tunnel Syndrome.

BACKGROUND: To investigate whether composite lipid indices and remnant cholesterol (RC) are associated with electrophysiological severity in carpal tunnel syndrome (CTS) and to evaluate their independ...

Targeting Inflammation in Atherosclerotic Cardiovascular Disease: Mechanisms and Emerging Therapies.

A large body of evidence has helped reframe atherosclerotic cardiovascular disease from a mere lipid storage disorder to a chronic inflammatory disease. Both innate and adaptive immune pathways contri...

Notoginsenoside R1 Alleviates Macrophage Inflammatory Responses via Modulating the JAK1/STAT3 Pathway.

Notoginsenoside R1 (NR1), an active component of Panax notoginseng, may exert anti-atherosclerotic effects by modulating macrophage M1/M2 polarization. This study aimed to investigate the specific mec...

Plantar Foot Microvascular Reactivity and Oxygenation in Type 2 Diabetes and Peripheral Artery Disease: An Exploratory Study.

OBJECTIVE: Microvascular dysfunction contributes to foot complications in type 2 diabetes (T2D) and peripheral artery disease (PAD), yet has been characterized primarily in non-plantar regions. We eva...

The risk of cardiovascular events in metabolic dysfunction-associated steatotic liver disease according to fibrosis stage and diabetes status: A cohort study.

BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is a major cause of morbidity and mortality in metabolic dysfunction-associated steatotic liver disease (MASLD). We investigated whether fibr...

Association between the Atherogenic Index of Plasma and in-Hospital Mortality in Individuals with Sepsis.

PURPOSE: Numerous studies have shown that the atherogenic index of plasma (AIP) is a strong predictor of the risk of cardiovascular diseases (CVDs) and an independent predictor of cardiovascular event...

Mechanistic Study of Platelet Membrane-Coated Resveratrol Nanosystem in Mitochondrial Dysfunction and Endothelial Senescence During Atherosclerotic Lesion Development via FOXM1 Activation.

Atherosclerosis (AS) is closely linked to endothelial cell (EC) senescence and mitochondrial dysfunction, which impair vascular repair. Resveratrol (RSV) has antioxidant, anti-inflammatory, and pro-an...

Differential Myopathic and Transcriptomic Changes in Soleus and Gastrocnemius Muscles in a Novel Chronic Hindlimb Ischemia Rat Model Induced by Endovascular Catheter Occlusion.

Peripheral artery disease (PAD) is a progressive atherothrombotic disorder affecting more than 230 million people worldwide. Conventional animal models of chronic hindlimb ischemia (HLI) are highly in...

Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein.

Atherosclerosis represents a major risk factor contributing to the development and advancement of cardiovascular diseases. The present study aimed to investigate the role of impaired autophagy and mit...

Glycemic variability, atherosclerosis, and arterial stiffness in persons with type 2 diabetes mellitus: A Mendelian randomization and epidemiologic study.

This study aimed to investigate the relationships between visit-to-visit variability in HbA1c and fasting plasma glucose (FPG) and atherosclerotic markers in persons with type 2 diabetes mellitus (T2D...

S100A8/A9 and S100A12 Proteins and Macrophage Polarization: Therapeutic Targets in Atherosclerosis.

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, immune cells, and fibrotic tissue within the arterial wall. Among the immune cells that drive this proces...

Chronotype and Atherogenic-Adiposity Indices in Adults Without Previously Diagnosed Chronic Disease: A Sex-Aware Cross-Sectional Study.

Background and Objectives: Chronotype and sleep quality are related but non-identical dimensions of sleep health. We examined whether later chronotype is associated with subclinical visceral adiposity...