Early identification of worsening heart failure (HF) may improve outcomes.

Lupus myocarditis mimicking peripartum cardiomyopathy: A diagnostic challenge and successful clinical management.

Lupus myocarditis and peripartum cardiomyopathy can both present with acute heart failure symptoms during the peripartum period, leading to diagnostic uncertainty. Accurate and timely recognition of l...

From Phenotype to Genotype and Beyond: Insights into Familial Hypercholesterolemia and Familial Hypertriglyceridemia.

Familial hypercholesterolemia (FH) and familial hypertriglyceridemia (FHTG) represent a spectrum of inherited conditions with profoundly different etiologies, risk profiles, and therapeutic implicatio...

Bioenergetics-Driven Extracellular Vesicle Therapies for Heart Failure: From Preclinical Insights to Regenerative Translation.

Heart failure (HF) is fundamentally a disease of energetic insufficiency, in which impaired mitochondrial efficiency, maladaptive metabolic remodeling, and disrupted intercellular signaling converge a...

Oxidative Stress and Its Impact on Reperfused Myocardium: Pathophysiological Insights and Therapeutic Perspectives.

Myocardial ischemia-reperfusion injury (MIRI) represents a major contributor to morbidity and mortality in patients undergoing reperfusion therapy after acute myocardial infarction. Although timely re...

Albumin-Based Drug Delivery for Glioblastoma Treatment: Mechanistic Rationale, Preclinical Evidence, and Clinical Translation.

Glioblastoma remains the most aggressive primary brain malignancy, with poor survival despite maximal safe resection, radiotherapy, and temozolomide-based chemotherapy. A major obstacle to effective t...

Patient Empowerment and Digital Health Readiness for Diabetes and Hypertension Care in Rwanda.

Patient empowerment remains a critical component in the management of non-communicable diseases, particularly in low-resource settings where health system constraints limit continuity of care. Diabete...

AI-Based ECG Analysis for Early Detection of Occlusion Myocardial Infarction Using Coronary Angiography Results.

Myocardial Infarction remains a high-mortality cardiovascular disease. While ST-Elevation Myocardial Infarction (STEMI) is the traditional intervention standard, many Occlusion Myocardial Infarction (...

First Insights into Sensor-Based Ballistocardiographic Measurements in Patients with Heart Failure.

Heart failure significantly impacts morbidity, mortality, physical functionality, and quality of life, presenting a high financial burden to healthcare systems. Early detection through non-invasive me...

Association of Remote Patient Monitoring with Care Utilization in Patients with Chronic Cardiopulmonary Conditions.

Remote patient monitoring (RPM) has shown potential benefits for patients with chronic conditions. This study aimed to compare healthcare utilization between RPM and non-RPM patients with congestive h...

Pre-Deployment Evaluation of a Remote Service for Short-Axis Cardiac MRI Segmentation.

Deploying cardiac segmentation models as remote inference services creates a black-box setting in which robustness under out-of-distribution shift is critical. We evaluated two candidate configuration...

Low-density lipoprotein cholesterol management and goal attainment at 1 year in patients with diabetes, pre-diabetes and normoglycaemia: results from the European, prospective, observational SANTORINI study.

OBJECTIVE: To assess changes in lipid-lowering therapy (LLT) use and low-density lipoprotein cholesterol (LDL-C) goal attainment through 1-year follow-up in patients stratified by diabetes status in S...

Late diagnosis of late onset Fabry disease.

A male in his 50s initially presented with left ventricular hypertrophy (LVH) identified on transthoracic echocardiogram. He was diagnosed with hypertrophic cardiomyopathy without any further investig...

The Immediate Impact of Infarct Size on the Systemic Inflammatory Response: IL-6 as Central Mediator Identified through Biomarker and Proteomic Profiling.

Myocardial infarction (MI) induces an inflammatory response that may be amenable to targeted therapy. This cohort study evaluated the systemic inflammatory burden across different infarct sizes using ...

Old marker, new face: anti-RNP as a sentinel of coronary and peripheral endothelial dysfunction in systemic lupus erythematosus.

OBJECTIVE: To investigate the association between anti-ribonucleoprotein (anti-RNP) antibodies and endothelial dysfunction (ED) in patients with SLE and their ability to predict early ED manifestation...

Cost-Effectiveness Analysis of Age-Specific N-Terminal Pro-B-Type Natriuretic Peptide Thresholds for Heart Failure Diagnosis in China: Protocol for a Markov Model-Based Study.

BACKGROUND: Heart failure (HF) imposes a substantial clinical and economic burden in China. Although N-terminal pro-B-type natriuretic peptide (NT-proBNP) is widely used in the diagnostic pathway for ...

A case of lipoprotein glomerulopathy in which complete remission was achieved by pemafibrate therapy.

Lipoprotein glomerulopathy (LPG) is a rare hereditary glomerular disease characterized by lipoprotein thrombi within dilated glomerular capillaries for which effective treatments remain limited. This ...

In Silico Discovery of mTOR Inhibitors as Potential Therapeutics for Feline Hypertrophic Cardiomyopathy.

CONTEXT: Feline Hypertrophic Cardiomyopathy (HCM) is a significant health issue, with a current prevalence of 14.7% in cats. The mammalian target of rapamycin (mTOR) is an atypical serine/threonine pr...

Atypical manifestations of dengue in pediatric patients hospitalized during the 2023-2024 epidemic in Argentina: a multicenter registry.

UNLABELLED: We aimed to characterize encephalitis, myositis, and myocarditis, in hospitalized children during the 2023 - 2024 dengue epidemic in Argentina. This case series included patients younger t...