Suppression of Post-Ischemic Cardiac Remodelling and Inflammatory Response by a Novel Sphingolipid Modifier, CIN038.
In patients with myocardial infarction (MI), the level of sphingolipids, such as ceramide (Cer), is elevated and is associated with an increased risk of progression towards heart failure (HF). Dihydro...
Sirtuins at the Interface of Glucose Metabolism, Diabetes, and Heart Failure: Metabolic Sensing in Cardiometabolic Disease.
Heart failure (HF) in the setting of diabetes represents a distinct cardiometabolic phenotype characterized by profound disturbances in myocardial glucose metabolism, mitochondrial function, and energ...
Berberine Stabilizes the Arrhythmogenic Substrate in Obese Rats by Klotho-Mediated Attenuation of Oxidative Stress and Inflammation.
Obesity increases susceptibility to ventricular arrhythmias due to an arrhythmogenic substrate by promoting oxidative stress and inflammation-driven cardiac remodeling. Klotho, an anti-aging protein t...
Special Issue "Atherosclerosis: From Molecular Biology to Therapeutic Perspective: 6th Edition".
Atherosclerosis remains a leading cause of morbidity and mortality worldwide, representing a complex and multifactorial disease at the intersection of aging, metabolism, inflammation, and environmenta...
Dietary Determinants of Mental Well-Being Among Cardiometabolic High-Risk Adults in Hungary.
Background: Mental well-being is an important yet often overlooked component of cardiometabolic health. Dietary habits may influence psychological outcomes, but evidence among high-risk populations in...
Istaroxime in Acute Heart Failure and Early Cardiogenic Shock: A Calcium-Cycling Approach to Inotropic Therapy.
Acute heart failure (AHF) and cardiogenic shock (CS) remain major causes of cardiovascular morbidity, mortality, and healthcare utilization worldwide. Although inotropic agents are central to the mana...
Bibliometric and Two-Sample Mendelian Randomization Analyses of the Causal Relationship Between Hypertension and Erectile Dysfunction.
Hypertension (HT)-related erectile dysfunction (ED), a condition secondary to HT, is characterized by a persistent inability to achieve or maintain an erection sufficient for satisfactory sexual perfo...
Identification of Candidate Biomarkers Associated with Mitochondrial Dysfunction and SUMOylation in Heart Failure Based on Bioinformatics Approaches.
Heart failure (HF) presents a persistent clinical challenge. While SUMOylation and mitochondrial function are vital for cardiomyocyte health, their combined influence on HF remains elusive. Two HF-rel...
Cardiac Metabolism in Healthy, Senescent and Diseased States.
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. The healthy adult heart depends on flexible energy use, but a diseased or injured heart is associated with a loss of flexibili...
The Role of LRP1 in Glioma Progression and Therapeutic Targeting: A Narrative Review.
Gliomas are the most frequently encountered tumors in the central nervous system, with limited therapeutic effectiveness owing to their highly invasive nature, intratumoral heterogeneity, and presence...
Glymphatic-Related Alterations in Major Depressive Disorder and Treatment-Resistant Depression: Imaging Proxies, Mechanistic Links, and Therapeutic Opportunities.
Major depressive disorder is increasingly conceptualized as a condition involving brain network dysfunction, neuroimmune imbalance, sleep-circadian disruption, hypothalamic-pituitary-adrenal (HPA)-axi...
Pouch-like infective endocarditis of the mitral valve.
Associations between atherogenic index of plasma and endometriosis: The National Health and Nutrition Examination Survey 1999 to 2006.
It has been proved that lipids have an effect on endometriosis, and the plasma atherosclerosis index (AIP), as a new lipid index, has not been proved to be correlative to endometriosis. The National H...
Machine learning-based early kidney stone risk classification in diabetic-hypertensive patients using obesity composite indices.
Kidney stone disease (KSD) is increasingly prevalent among patients with diabetes mellitus and hypertension. Obesity-related metabolic abnormalities may be associated with stone formation, yet their c...
Vitamin D as a mediator in the J-shaped association between serum uric acid and all-cause and cardiovascular mortality in patients with cardiovascular-kidney-metabolic syndrome: A prospective cohort study.
The relationship between serum uric acid (UA) and mortality in patients with cardiovascular-kidney-Metabolic (CKM) syndrome remains unclear. We hypothesized that elevated UA increases mortality nonlin...
Research on identification of key genes and immune-metabolic mechanisms in atrial fibrillation through integrated multi-cohort transcriptomic analysis and machine learning.
This study aimed to integrate multiple datasets for the identification of atrial fibrillation (AF)-related differentially expressed genes (DEGs), analyze their underlying mechanisms through functional...
Genetically predicted lower FLT3L levels increase the risk of hypertrophic cardiomyopathy partly mediated by phosphate: Evidence from a 2-step Mendelian randomization analysis.
We performed a 2-step Mendelian randomization (MR) study to investigate the associations of Fms-related tyrosine kinase 3 ligand (FLT3L) and phosphate levels with the risk of hypertrophic cardiomyopat...
Risk factors for unanticipated hypertension during emergence from general anesthesia in elderly surgical patients: A retrospective cohort analysis.
Unanticipated hypertension in the postanesthesia care unit (PACU) refers to acute blood pressure elevation in patients whose preoperative baseline blood pressure was normal, possibly resulting in adve...
Association between weekend catch-up sleep and metabolic syndrome: A cross-sectional study.
The association between weekend catch-up sleep (WCS) and the prevalence of metabolic syndrome (MetS) remains controversial. This study aimed to investigate the association between WCS and MetS. This c...
Molecular profiling of coronary stent testenosis: A systematic review and functional analysis of implicated genes.
BACKGROUND: Coronary stent restenosis occurs in approximately 5% of patients treated with drug-eluting stents (DES) and is associated with adverse clinical outcomes. Elucidating the genetic mechanisms...