Antibody-drug conjugates in breast cancer brain and leptomeningeal metastases: mechanistic insights and therapeutic progress.
Antibody-drug conjugates (ADCs) are targeted therapies that employ monoclonal antibodies to deliver potent cytotoxic agents to cancer cells. The treatment of breast cancer with brain and leptomeningea...
Neurochemical Mechanisms Underlying Tanshinone-Mediated Neuroprotection and Formulation Strategies in Cerebral Ischemia/Reperfusion Injury.
Cerebral ischemia/reperfusion (I/R) injury represents a major pathological component of ischemic stroke and is driven by a complex cascade of neurochemical and molecular events, including excitotoxici...
Fluorescence-lifetime optical electrophysiology in contracting cardiomyocytes.
Precise monitoring of cardiac electrophysiology in vitro is crucial to understanding heart function and cardiac disease. However, high-throughput, contact-free methods for directly measuring excitatio...
Cardiac intensive care units are specialized, high-acuity, and resource-intensive environments for the care of critically ill patients with cardiovascular disease. Over the past 60 years, medical and ...
The emerging function of MYPT1 as a biomarker and therapeutic target.
Recent research suggests that isoforms of myosin phosphatase target subunit 1 (MYPT1) may influence blood pressure regulation by altering smooth muscle responsiveness and, as a result, the function of...
Pericoronary, but Not Epicardial, Cardiac Fat Thickness Is Associated with Sarcopenia in Hospitalized Older Adults.
Background and Objectives: Sarcopenia is a major geriatric condition associated with functional decline and adverse outcomes. Cardiac fat depots exhibit metabolic activity and are linked to cardiometa...
Familial Hypercholesterolemia in Women: Diagnosis, Treatment, and Cardiovascular Outcomes Across the Lifespan.
PURPOSE OF REVIEW: Familial hypercholesterolemia (FH) is a common monogenic lipid disorder, characterized by lifelong elevated low-density lipoprotein cholesterol (LDL-C) and a markedly increased risk...
A Proposed Anatomical-Fluoroscopic Workflow to Identify the Optimal Split Line for Leaflet Modification in Redo-TAVR.
BACKGROUND: The optimal leaflet modification strategy in redo transcatheter aortic valve replacement (TAVR) needs further refinement. OBJECTIVES: The aims of this study were to clarify the anatomical ...
Leaflet Modification for Redo-TAVR: Impact of Valve Type, Expansion, and Failure Mode-A Bench Study.
BACKGROUND: Leaflet modification (LM) techniques are of interest in redo transcatheter aortic valve replacement (TAVR). However, factors impacting the efficacy of LM are poorly understood. OBJECTIVES:...
Current Evidence, Emerging Evidence, and Decision-Making: An Algorithm for Leaflet Modification Procedures.
Leaflet modification is a necessary element in the armamentarium of the structural interventionalist and will remain an area of active investment in the future. Although leaflet splitting is proven, t...
Comparison of Leaflet Modification Techniques for TAV-in-TAV: Insights From Bench Testing.
BACKGROUND: Transcatheter aortic valve (TAV) leaflet modification can reduce the risk for coronary obstruction caused by the leaflet neoskirt created during TAV-in-TAV procedures. OBJECTIVES: The aim ...
Leaflet Splitting to Prevent TAVR-Induced Coronary Obstruction in Stented vs Stentless Surgical Bioprosthetic Valves.
BACKGROUND: Transcatheter electrosurgical leaflet splitting prevents coronary artery obstruction (CAO) following transcatheter aortic valve replacement (TAVR), particularly in valve-in-valve intervent...
Comparing bridging drug therapy approaches prior to balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: a prospective analysis from the national UK CURATE registry.
BACKGROUND: Pulmonary hypertension (PH) medical therapies are commonly used as a bridge to balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic PH (CTEPH) but their effectivenes...
Aortic Valve Leaflet Modification: A Working Group Position Statement on Best Practices and Step-by-Step Guide.
Coronary artery obstruction is a potential life-threatening complication of transcatheter aortic valve replacement (TAVR) in all settings including native, valve-in-valve, and redo-TAVR. Risk of obstr...
Revolutionizing Sectioned Images of the Visible Korean: Achieving From 0.05 mm to 0.03 mm Sized Pixel.
BACKGROUND: The Visible Korean (VK) project aimed to overcome the limitations of traditional cadaver dissection by producing high-resolution sectioned images. This study compared a newly acquired 2024...
Association between hypertension status and severity and tinnitus: a cross-sectional analysis of the Fasa adult cohort study.
BACKGROUND: Previous studies and meta-analyses suggest an association between hypertension and tinnitus; however, the influence of hypertension severity and control status remains unclear. OBJECTIVE: ...
Prognostic value of stress perfusion cardiac magnetic resonance in patients with known or suspected coronary artery disease and supranormal left ventricular ejection fraction.
BACKGROUND: Prior studies have shown that a supranormal range of left ventricular ejection fraction (LVEF) is associated with adverse cardiovascular outcomes. However, the prognostic value of stress p...
Impact of Tissue Treatment and Leaflet Design on Fifth-Generation Balloon-Expandable Transcatheter Heart Valve Function.
BACKGROUND: The SAPIEN 3 Ultra RESILIA (S3UR) transcatheter heart valve incorporates RESILIA-treated tissue and new commissural attachments in smaller valve sizes (20 and 23 mm). However, detailed per...
CT-Based Risk Stratification of Coronary Obstruction During TAVR: Clinical Utility and a New Volumetric Parameter.
BACKGROUND: Coronary obstruction (CO) during transcatheter aortic valve replacement (TAVR) is rare but potentially fatal. Computed tomography (CT)-based risk assessment algorithms aim to identify high...
Impact of Leaflet Modification on the Occurrence of Hypoattenuated Leaflet Thickening After Valve-in-Valve Transcatheter Aortic Valve Replacement.
BACKGROUND: Valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) is an established therapy for failed bioprosthetic valves but carries risks for coronary obstruction and subclinical leaf...