Temporal Orchestration of Krüppel-like Factors During Cardiac Remodeling Following Isoproterenol-Induced Myocardial Injury.
Background: Myocardial infarction triggers a complex remodeling process involving inflammation, hypertrophy, fibrosis, and electrical adaptation, ultimately predisposing the heart to failure. Krüppel-...
Integration of Machine Learning Techniques in ECG-Based Multiclass Arrhythmia Classification with Explainability Analysis.
Electrocardiogram (ECG) analysis is a cornerstone non-invasive diagnostic technique for detecting cardiac arrhythmias, which remain a leading cause of mortality worldwide. While recent advances in dee...
Effect of Oat Flakes on Glycemic Variability, Dyslipidemia, and Pancreatic Duodenum Homeobox-1 (PDX-1) Level Among Adolescents with Type 1 Diabetes: A Randomized Crossover Study.
Aims: Murine studies show a promising effect of high-fiber β-glucan on glycemic control and serum lipids. In addition, β-glucan has recently been found to have strong antioxidant and immunomodulatory ...
Metabolic Syndrome: a Clinical Case Report and Literature Review.
BACKGROUND/AIMS: To present a clinical case of metabolic syndrome (MetS) and to provide a concise pathophysiological overview with emphasis on underlying metabolic and inflammatory mechanisms. METHODS...
Tianjin Health and Chronic Disease Study (THCDS): study design and baseline characteristics of the cohort - cohort profile.
PURPOSE: The Tianjin Health and Chronic Disease Study (THCDS) is a longitudinal dynamic cohort study established in 2022, aiming to investigate risk factors and intervention targets of common non-comm...
Association between venous access-site closure device use and postoperative nausea and vomiting after atrial fibrillation ablation under propofol sedation: a single-centre retrospective observational study in Okayama, Japan.
OBJECTIVES: To examine whether the use of a venous access-site closure device is associated with the occurrence of postoperative nausea and vomiting (PONV) after atrial fibrillation (AF) ablation unde...
Primary Health Care approach to managing chronic kidney disease.
Chronic kidney disease (CKD) is a growing global health issue among ageing populations, driven by increasing diabetes and hypertension. Managing advanced stages of CKD with dialysis or transplants is ...
Explainable machine-learning model for coronary artery disease diagnosis in non-AMI patients: integrating inflammatory and traditional risk factors.
OBJECTIVE: To develop and interpret an explainable machine learning (ML) model integrating inflammatory biomarkers and traditional risk factors for the diagnosis of coronary artery disease (CAD). METH...
Perfusion Parameters to Identify Acute Steno-occlusive Carotid Artery Disease Due to Atherosclerosis Prior to Endovascular Therapy.
BACKGROUND AND PURPOSE: Perfusion imaging is commonly utilized to assess collateral status in patients with acute ischemic stroke due to anterior large-vessel occlusion. However, its potential role in...
A systematic review of machine learning algorithms for mortality risk, readmission and phenotype prediction in patients with heart failure: exploring key data sources, input variables and outcomes.
BACKGROUND: Heart failure is not only a prevalent disease with a high mortality rate, but also generates high costs for healthcare systems. By training artificial intelligence (AI) models on medical d...
Detection of previously undiagnosed conditions in midlife preventive health examinations.
This study aimed to investigate the prevalence of previously undocumented suspected diagnoses identified during preventive health examinations in middle-aged adults, and to examine their associations ...
Retinal microvascular alterations consistent with endothelial dysregulation in paediatric post-COVID-19 syndrome: A prospective matched-cohort study.
Persistent symptoms following SARS-CoV-2 infection in children remain poorly understood, and objective biological correlates are scarce. The vascular endothelium is considered a central target of post...
Symptomatic branch retinal artery occlusion as a presenting sign of carotid artery occlusion.
A man in his late 60s with a history of arterial hypertension, dyslipidaemia and a cerebrovascular accident 20 years ago presented to the emergency department with sudden-onset blurred vision in his r...
SLC11A1 Drives Ferroptosis in Acute Myocardial Infarction Via Sp1-mediated Transcriptional Repression of GPX4.
Ferroptosis is a critical contributor to cardiomyocyte injury in acute myocardial infarction (AMI). This study aimed to identify key ferroptosis-associated genes and elucidate their roles in AMI. Tran...
pedQTNet: A Deep Learning Approach to Estimate Corrected QT Intervals from Multi-Lead Conventional ECG Waveforms in Pediatric Patients.
Long QT syndrome (LQTS) is a primary risk factor for ventricular arrhythmias and sudden cardiac death in children. Accurate corrected QT intervals (QTc) measurement is imperative but challenging for n...
Beyond the ICD: Navigating Ventricular Tachycardia Suppression Strategies in the Modern Era.
PURPOSE OF REVIEW: Management of patients with an implantable cardioverter defibrillator (ICD) and ventricular tachycardia (VT) is a common clinical challenge. Suppression is often warranted. Catheter...
A monolithic patient-specific 3D-0D model for In silico investigation of hemodynamics in patients with left ventricular assist devices.
We present a fully coupled, patient-specific 3D-0D computational framework for hearts supported with left ventricular assist devices (LVAD) that enables controlled in silico experimentation. The appro...
A data-driven computational methodology for assessing ventricular ablation procedures.
Ventricular tachycardia following myocardial infarction is often sustained by complex reentrant circuits that are challenging to characterize and treat using conventional electroanatomical mapping. Co...
Treadmill Exercise Alleviates Motor Deficits of PD Mice via Regulating STING-Mediated Valeric Acid-Th17/Treg-IL-17A Axis.
The objective of this study is to investigate the effects of treadmill exercise on motor deficits in chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/p)-induced chronic Parkinson'...
Pituicyte-derived TGFβ2 regulates Col15a1 expression in pericytes of the rat posterior pituitary.
The posterior lobe (PL) of the pituitary contains a specialized neurovascular junction, where neurosecretory axon terminals closely associate with fenestrated capillaries to enable efficient hormone r...